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Archives of Orthopaedic and Trauma Surgery

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01-09-2013 | Arthroscopy and Sports Medicine

Platelet-rich plasma in patients with tibiofemoral cartilage degeneration

Authors: Radek Hart, Adel Safi, Martin Komzák, Pavel Jajtner, Miloš Puskeiler, Petra Hartová

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 9/2013

Abstract

Introduction

Recently an articular cartilage repair has been given much attention in the orthopaedic field. Cartilage regeneration capacity is very limited. Optimal approach seems to be a delivery of natural growth factors. Autologous platelet-rich plasma (PRP) contains proliferative and chemoattractant growth factors. The objective of the present study was to determine if PRP can increase tibiofemoral cartilage regeneration and improve knee function.

Materials and methods

Fifty consecutive and strictly selected patients, affected by Grade II or III chondromalatia, underwent 1 year treatment (9 injections) with autologous PRP in a liquid form with 2.0 to 2.5-fold platelets concentration. Outcome measures included the Lysholm, Tegner, IKDC, and Cincinnati scores. Magnetic resonance imaging was used to evaluate cartilage thickness and degree of degeneration.

Results

The study demonstrated significant improvement in Lysholm (p < 0.05), Tegner (p < 0.05), IKDC (p < 0.05), and Cincinnati (p < 0.05) scores. Results improved at 12-month follow-up. Cartilage assessment revealed no significant cartilage regeneration (p < 0.05). There were no adverse events reported.

Conclusions

PRP significantly reduced pain and improved quality of live in patients with low degree of cartilage degeneration. Magnetic resonance imaging did not confirmed any significant cartilage condition improvement.

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Title: Platelet-rich plasma in patients with tibiofemoral cartilage degeneration
Authors: Radek Hart
Adel Safi
Martin Komzák
Pavel Jajtner
Miloš Puskeiler
Petra Hartová
Publication date: 01-09-2013
Publisher: Springer Berlin Heidelberg
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 9/2013
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-013-1782-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Platelet-rich plasma in patients with tibiofemoral cartilage degeneration

Abstract

Introduction

Materials and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Conclusions

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