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Published in: Medical Oncology 5/2021

01-05-2021 | Acute Myeloid Leukemia | Review Article

The role of various interleukins in acute myeloid leukemia

Authors: Erin C. Kaser, Lei Zhao, Kyle P. D’mello, Ziwen Zhu, Huaping Xiao, Mark R. Wakefield, Qian Bai, Yujiang Fang

Published in: Medical Oncology | Issue 5/2021

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Abstract

Interleukins are signaling molecules involved in the immune system, and they play a variety of roles in different diseases and cancers. Acute myeloid leukemia (AML) is the most common type of leukemia in adults, and survival rate after diagnosis is very low. Investigating the role interleukins play in AML can help understand the progression of the disease. There exists a need for more effective treatment of AML. Interleukins can be used to guide immunotherapy for AML. This review article will examine how specific interleukins play a role in AML disease progression and how they can be utilized as a future treatment option.
Literature
4.
go back to reference Dmitrieva O, Shilovskiy I, Khaitov M, Grivennikov S. Interleukins 1 and 6 as main mediators of inflammation and cancer. Biochem Mosc. 2016;81(2):80–90.CrossRef Dmitrieva O, Shilovskiy I, Khaitov M, Grivennikov S. Interleukins 1 and 6 as main mediators of inflammation and cancer. Biochem Mosc. 2016;81(2):80–90.CrossRef
6.
go back to reference Davis AS, Viera AJ, Mead MD. Leukemia: an overview for primary care. Am Fam Physician. 2014;89(9):731–8.PubMed Davis AS, Viera AJ, Mead MD. Leukemia: an overview for primary care. Am Fam Physician. 2014;89(9):731–8.PubMed
7.
go back to reference Ratnam KV, Khor CJ, Su WP. Leukemia cutis. Dermatol Clin. 1994;12(2):419–31.CrossRef Ratnam KV, Khor CJ, Su WP. Leukemia cutis. Dermatol Clin. 1994;12(2):419–31.CrossRef
13.
go back to reference Döhner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373(12):1136–52.CrossRef Döhner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373(12):1136–52.CrossRef
18.
go back to reference Cozzolino F, Rubartelli A, Aldinucci D, Sitia R, Torcia M, Shaw A, et al. Interleukin 1 as an autocrine growth factor for acute myeloid leukemia cells. Proc Natl Acad Sci. 1989;86(7):2369–73.CrossRef Cozzolino F, Rubartelli A, Aldinucci D, Sitia R, Torcia M, Shaw A, et al. Interleukin 1 as an autocrine growth factor for acute myeloid leukemia cells. Proc Natl Acad Sci. 1989;86(7):2369–73.CrossRef
20.
go back to reference Nishioka C, Ikezoe T, Pan B, Xu K, Yokoyama A. Micro RNA-9 plays a role in interleukin-10-mediated expression of E-cadherin in acute myelogenous leukemia cells. Cancer Sci. 2017;108(4):685–95.CrossRef Nishioka C, Ikezoe T, Pan B, Xu K, Yokoyama A. Micro RNA-9 plays a role in interleukin-10-mediated expression of E-cadherin in acute myelogenous leukemia cells. Cancer Sci. 2017;108(4):685–95.CrossRef
22.
go back to reference Wróbel T, Gębura K, Wysoczańska B, Jaźwiec B, Dobrzyńska O, Mazur G, et al. IL-17F gene polymorphism is associated with susceptibility to acute myeloid leukemia. J Cancer Res Clin Oncol. 2014;140(9):1551–5.CrossRef Wróbel T, Gębura K, Wysoczańska B, Jaźwiec B, Dobrzyńska O, Mazur G, et al. IL-17F gene polymorphism is associated with susceptibility to acute myeloid leukemia. J Cancer Res Clin Oncol. 2014;140(9):1551–5.CrossRef
27.
go back to reference Xu DH, Zhu Z, Xiao H, Wakefield MR, Bai Q, Nicholl MB, et al. Unveil the mysterious mask of cytokine-based immunotherapy for melanoma. Cancer Lett. 2017;394:43–51.CrossRef Xu DH, Zhu Z, Xiao H, Wakefield MR, Bai Q, Nicholl MB, et al. Unveil the mysterious mask of cytokine-based immunotherapy for melanoma. Cancer Lett. 2017;394:43–51.CrossRef
30.
go back to reference Berraondo P, Etxeberria I, Ponz-Sarvise M, Melero I. Revisiting interleukin-12 as a cancer immunotherapy agent. Clin Cancer Res. 2018;24(12):2716–8.CrossRef Berraondo P, Etxeberria I, Ponz-Sarvise M, Melero I. Revisiting interleukin-12 as a cancer immunotherapy agent. Clin Cancer Res. 2018;24(12):2716–8.CrossRef
31.
go back to reference Anestakis D, Petanidis S, Kalyvas S, Nday CM, Tsave O, Kioseoglou E, et al. Mechanisms and αpplications of ιnterleukins in cancer immunotherapy. Int J Mol Sci. 2015;16(1):1691–710.CrossRef Anestakis D, Petanidis S, Kalyvas S, Nday CM, Tsave O, Kioseoglou E, et al. Mechanisms and αpplications of ιnterleukins in cancer immunotherapy. Int J Mol Sci. 2015;16(1):1691–710.CrossRef
34.
go back to reference Van Acker HH, Anguille S, De Reu H, Berneman ZN, Smits EL, Van Tendeloo VF. Interleukin-15-cultured dendritic cells enhance anti-tumor gamma delta T cell functions through IL-15 secretion. Front Immunol. 2018;9:658.CrossRef Van Acker HH, Anguille S, De Reu H, Berneman ZN, Smits EL, Van Tendeloo VF. Interleukin-15-cultured dendritic cells enhance anti-tumor gamma delta T cell functions through IL-15 secretion. Front Immunol. 2018;9:658.CrossRef
Metadata
Title
The role of various interleukins in acute myeloid leukemia
Authors
Erin C. Kaser
Lei Zhao
Kyle P. D’mello
Ziwen Zhu
Huaping Xiao
Mark R. Wakefield
Qian Bai
Yujiang Fang
Publication date
01-05-2021
Publisher
Springer US
Published in
Medical Oncology / Issue 5/2021
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-021-01498-7

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