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Clinical Reviews in Allergy & Immunology

Published in:

Open Access 01-06-2020

Role of Mast Cells in Shaping the Tumor Microenvironment

Authors: Daniel Elieh Ali Komi, Frank A. Redegeld

Published in: Clinical Reviews in Allergy & Immunology | Issue 3/2020

Abstract

Early mast cell (MC) infiltration has been reported in a wide range of human and animal tumors particularly malignant melanoma and breast and colorectal cancer. The consequences of their presence in the tumor microenvironment (TME) or at their margins still remain unclear as it is associated with a good or poor prognosis based on the type and anatomical site of the tumor. Within the tumor, MC interactions occur with infiltrated immune cells, tumor cells, and extracellular matrix (ECM) through direct cell-to-cell interactions or release of a broad range of mediators capable of remodeling the TME. MCs actively contribute to angiogenesis and induce neovascularization by releasing the classical proangiogenic factors including VEGF, FGF-2, PDGF, and IL-6, and nonclassical proangiogenic factors mainly proteases including tryptase and chymase. MCs support tumor invasiveness by releasing a broad range of matrix metalloproteinases (MMPs). MC presence within the tumor gained additional significance when it was assumed that controlling its activation by tyrosine kinase inhibitors (imatinib and masitinib) and tryptase inhibitors (gabexate and nafamostat mesylate) or controlling their interactions with other cell types may have therapeutic benefit.

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Title: Role of Mast Cells in Shaping the Tumor Microenvironment
Authors: Daniel Elieh Ali Komi
Frank A. Redegeld
Publication date: 01-06-2020
Publisher: Springer US
Published in: Clinical Reviews in Allergy & Immunology / Issue 3/2020
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-019-08753-w

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Role of Mast Cells in Shaping the Tumor Microenvironment

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Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

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Springer Medicine

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Other articles of this Issue 3/2020

Using Baseline and Peak Serum Tryptase Levels to Diagnose Anaphylaxis: a Review

Bee Venom Immunotherapy: Current Status and Future Directions

Mast Cell Biology at Molecular Level: a Comprehensive Review

Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions

The Relationship Between Hypermobile Ehlers-Danlos Syndrome (hEDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS)

The Role of Mast Cells in IgE-Independent Lung Diseases

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