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01-12-2019 | Magnetic Resonance Imaging | Bone Marrow and Adipose Tissue (G Duque and B Lecka-Czernik, Section Editors)

Bone Marrow Adipose Tissue Quantification by Imaging

Authors: Ebrahim Bani Hassan, Ali Ghasem-Zadeh, Mahdi Imani, Numan Kutaiba, David K. Wright, Tara Sepehrizadeh, Gustavo Duque

Published in: Current Osteoporosis Reports | Issue 6/2019

Abstract

Purpose of Review

The significance and roles of marrow adipose tissue (MAT) are increasingly known, and it is no more considered a passive fat storage but a tissue with significant paracrine and endocrine activities that can cause lipotoxicity and inflammation.

Recent Findings

Changes in the MAT volume and fatty acid composition appear to drive bone and hematopoietic marrow deterioration, and studying it may open new horizons to predict bone fragility and anemia development. MAT has the potential to negatively impact bone volume and strength through several mechanisms that are partially described by inflammaging and lipotoxicity terminology.

Summary

Evidence indicates paramount importance of MAT in age-associated decline of bone and red marrow structure and function. Currently, MAT measurement is being tested and validated by several techniques. However, purpose-specific adaptation of existing imaging technologies and, more importantly, development of new modalities to quantitatively measure MAT are yet to be done.

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Title: Bone Marrow Adipose Tissue Quantification by Imaging
Authors: Ebrahim Bani Hassan
Ali Ghasem-Zadeh
Mahdi Imani
Numan Kutaiba
David K. Wright
Tara Sepehrizadeh
Gustavo Duque
Publication date: 01-12-2019
Publisher: Springer US
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Computed Tomography
Computed Tomography
Published in: Current Osteoporosis Reports / Issue 6/2019
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-019-00539-5

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Springer Medicine

Bone Marrow Adipose Tissue Quantification by Imaging

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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Insulin Signaling in Bone Marrow Adipocytes