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Journal of Neuro-Oncology

Published in:

01-02-2019 | Glioblastoma | Topic Review

Established and emerging uses of 5-ALA in the brain: an overview

Authors: Ricardo Díez Valle, Constantinos G. Hadjipanayis, Walter Stummer

Published in: Journal of Neuro-Oncology | Issue 3/2019

Abstract

Introduction

5-aminolevulinic acid (5-ALA) was approved by the FDA in June 2017 as an intra-operative optical imaging agent for patients with gliomas (suspected World Health Organization Grades III or IV on preoperative imaging) as an adjunct for the visualization of malignant tissue during surgery. 5-ALA fluorescence-guided surgery (FGS) has been in widespread use in Europe and other continents since 2007.

Methods

We reviewed the data available and summarize the most important known uses of 5-ALA FGS and its potential future applications.

Results/conclusions

The technique has been extensively studied, and more than 300 papers have been published on this topic. Visualization of high-grade glioma tissue is robust and reproducible, and can impact the extent of tumor resection and patient outcomes. 5-ALA FGS for other kind of tumors needs further development.

Graphical abstract

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Title: Established and emerging uses of 5-ALA in the brain: an overview
Authors: Ricardo Díez Valle
Constantinos G. Hadjipanayis
Walter Stummer
Publication date: 01-02-2019
Publisher: Springer US
Keywords: Glioblastoma
Ependymoma
Glioma
Meningioma
Photodynamic Therapy
Glioma
Ependymoma
Glioblastoma
Meningioma
Ependymoma
Glioblastoma
Glioma
Published in: Journal of Neuro-Oncology / Issue 3/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-03087-7

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Established and emerging uses of 5-ALA in the brain: an overview

Abstract

Introduction

Methods

Results/conclusions

Graphical abstract

At a glance: The ONWARDS insulin icodec trials

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Abstract

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Results/conclusions

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