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Journal of Neuro-Oncology

Published in:

01-02-2019 | Topic Review

Fluorescence guided surgery by 5-ALA and intraoperative MRI in high grade glioma: a systematic review

Authors: Jan Coburger, Christian Rainer Wirtz

Published in: Journal of Neuro-Oncology | Issue 3/2019

Abstract

Purpose

Fluorescence guided surgery by 5-aminolevulinic acid (5-ALA) and intraoperative MRI (iMRI) are currently the most important intraoperative imaging techniques in high grade glioma (HGG) surgery. Few comparative studies exist for these techniques. This review aims to systematically compare 5-ALA and iMRI assisted surgery based on the current literature and discuss the potential impact of a combined use of both techniques.

Methods

A systematic literature search based on preferred reporting items for systematic reviews and meta-analysis was performed concerning accuracy of tumor detection; extent of resection; neurological deficits (ND); Quality of life (QoL); usability and combined use of both techniques. Original clinical articles on HGG published until March 31st were screened.

Results

169 publications were screened, 81 were eligible and 22 were finally included in the review using. Overall, there is evidence that both imaging techniques improve gross total resection rate in non-eloquent lesions. Imaging results do not correlate at the border zone of a HGG. 5-ALA and contrast-enhanced iMRI seem to have a supplementary effect in tumor detection. Overall, both imaging techniques alone or combined do not seem to increase rate of permanent ND or decrease QoL in HGG surgery when used with intraoperative monitoring/mapping.

Conclusion

Based on the currently available literature no superiority of one technique over the other can be found in the most important outcome parameters. Based on the available information a combined use of 5-ALA and iMRI seems very promising to achieve a resection beyond gadolinium-enhancement. However, only low quality of evidence exists for this approach.

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Title: Fluorescence guided surgery by 5-ALA and intraoperative MRI in high grade glioma: a systematic review
Authors: Jan Coburger
Christian Rainer Wirtz
Publication date: 01-02-2019
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-03052-4

At a glance: The STEP trials

Springer Medicine

Fluorescence guided surgery by 5-ALA and intraoperative MRI in high grade glioma: a systematic review

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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