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Journal of Neuro-Oncology

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01-02-2019 | Meningioma | Topic Review

5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

Authors: Pablo A. Valdes, Matthias Millesi, Georg Widhalm, David W. Roberts

Published in: Journal of Neuro-Oncology | Issue 3/2019

Abstract

Introduction

5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors.

Methods

Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas.

Results

We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas.

Conclusions

The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.

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Title: 5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery
Authors: Pablo A. Valdes
Matthias Millesi
Georg Widhalm
David W. Roberts
Publication date: 01-02-2019
Publisher: Springer US
Keywords: Meningioma
Meningioma
Published in: Journal of Neuro-Oncology / Issue 3/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-03079-7

At a glance: The STEP trials

Springer Medicine

5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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