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Journal of Assisted Reproduction and Genetics

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01-04-2013 | Technological Innovations

Sperm selection using magnetic activated cell sorting (MACS) in assisted reproduction: a systematic review and meta-analysis

Authors: Monica Gil, Valerie Sar-Shalom, Yolisid Melendez Sivira, Ramon Carreras, Miguel Angel Checa

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2013

Abstract

Purpose

To determine whether the use of Magnetic Activated Cell Sorting (MACS) as a sperm selection technique improves ART success rates in couples undergoing assisted reproduction treatment.

Methods

Systematic review and meta-analysis of prospective randomized trials. Two reviewers conducted study selection and data extraction independently.

Results

Five studies (prospective randomized trials) that comprised 499 patients were included. Sperm selection using MACS resulted in statistically significant differences in pregnancy rates when compared with density gradient centrifugation and swim-up techniques (RR = 1.50, 95 % CI 1.14–1.98). No differences were found between the groups according to the implantation (RR = 1.03, 95 % CI 0.80–1.31) and miscarriage (RR = 2.00, 95 % CI 0.19–20.90) rates.

Conclusions

MACS appears to be a safe and efficient method to select functional sperm with consistently good results. This technique may improve pregnancy rates when used to complement standard sperm selection methods in ART.

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Title: Sperm selection using magnetic activated cell sorting (MACS) in assisted reproduction: a systematic review and meta-analysis
Authors: Monica Gil
Valerie Sar-Shalom
Yolisid Melendez Sivira
Ramon Carreras
Miguel Angel Checa
Publication date: 01-04-2013
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 4/2013
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-013-9962-8

ACC 2024 Congress

Springer Medicine

Sperm selection using magnetic activated cell sorting (MACS) in assisted reproduction: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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