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Journal of Assisted Reproduction and Genetics

Published in:

01-04-2013 | ASSISTED REPRODUCTION TECHNOLOGIES

Failure of GnRH agonist-triggered oocyte maturation: its cause and management

Authors: Yoshimasa Asada, Fumiaki Itoi, Hiroyuki Honnma, Shuji Takiguchi, Noritaka Fukunaga, Yoshiki Hashiba, Tsuyoshi Baba, Toshiaki Endo

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2013

Abstract

Objective

In the present study we investigated the cause of GnRHa’s failure to trigger oocyte maturation and present an effective rescue protocol for use when failure occurs.

Design

Case reports.

Setting

One in vitro fertilization (IVF) center.

Patient(s)

Eight cases of failure of GnRH agonist (GnRHa)-triggered oocyte maturation and one case of GnRHa successfully triggered oocyte maturation, despite a weak response in the LH-RH test.

Main Outcome Measure(s)

All cases were successfully rescued by re-triggering maturation using HCG, with seven of the eight patients achieving ongoing pregnancy and successful delivery.

Result(s)

In three patients the cause of the oocyte maturation failure was likely temporal or continuous severe down-regulation of the hypothalamus-pituitary-axis, the cause was unknown in the other five patients.

Conclusion(s)

In cases where GnRHa fails to trigger oocyte maturation, a rescue protocol entailing re-triggering with HCG can produce successful outcomes.

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Title: Failure of GnRH agonist-triggered oocyte maturation: its cause and management
Authors: Yoshimasa Asada
Fumiaki Itoi
Hiroyuki Honnma
Shuji Takiguchi
Noritaka Fukunaga
Yoshiki Hashiba
Tsuyoshi Baba
Toshiaki Endo
Publication date: 01-04-2013
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 4/2013
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-013-9966-4

At a glance: The STEP trials

Springer Medicine

Failure of GnRH agonist-triggered oocyte maturation: its cause and management

Abstract

Objective

Design

Setting

Patient(s)

Main Outcome Measure(s)

Result(s)

Conclusion(s)

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Design

Setting

Patient(s)

Main Outcome Measure(s)

Result(s)

Conclusion(s)

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