Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
International Ophthalmology
Published in: International Ophthalmology 2/2020

Open Access 01-02-2020 | Osteoarthrosis | Review

Ocular manifestations of rheumatic diseases

Authors: Adam Kemeny-Beke, Peter Szodoray

Published in: International Ophthalmology | Issue 2/2020

Login to get access

Abstract

Purpose

Our aim was to summarize key aspects of the pathomechanism and the ocular involvements of rheumatic and systemic autoimmune diseases.

Methods

Apart from a paper in French (Morax V, Ann Oculist 109:368–370, 1893), all papers referred to in this article were published in English. All the materials were peer-reviewed full-text papers, letters, reviews, or book chapters obtained through a literature search of the PubMed database using the keywords ocular manifestations; pathogenesis; systemic inflammatory rheumatic diseases; rheumatoid arthritis; osteoarthritis; fibromyalgia; systemic lupus erythematosus; seronegative spondyloarthritis; ankylosing spondylitis; reactive arthritis; enteropathic arthritis; psoriatic arthritis; systemic sclerosis; polymyalgia rheumatica and covering all years available. Some statements articulated in this paper reflect the clinical experience of the authors in their tertiary-referral center.

Results

Ophthalmic disorders are categorized by anatomical subgroups in all rheumatic diseases. The most common ocular manifestations are diverse types of inflammations of different tissues and dry eye disease (DED).

Conclusion

The eye could be a responsive marker for the onset or aggravation of an immune reactivation in many rheumatic diseases, furthermore, ocular findings can antedate the diagnosis of the underlying rheumatic disease. By recognizing ocular manifestations of systemic rheumatic diseases it might be possible to avoid or at least delay many long term sequelae.
Literature
1.
Szodoray P, Nakken B, Barath S, Gaal J, Aleksza M, Zeher M, Sipka S, Szilagyi A, Zold E, Szegedi G, Bodolay E (2008) Progressive divergent shifts in natural and induced T-regulatory cells signify the transition from undifferentiated to definitive connective tissue disease. Int Immunol 20:971–979PubMed
2.
Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd et al (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 69:1580–1588PubMed
3.
Singh G, Salvador VB, Bagchi A, Tushabe R, Abrudescu A (2014) Rheumatoid arthritis-associated corneal ulceration with superimposed infection by methicillin-resistant Staphylococcus aureus: a complicated type of corneal melt. Am J Case Rep 15:523–525PubMedPubMedCentral
4.
Selmi C (2014) Diagnosis and classification of autoimmune uveitis. Autoimmun Rev 13:591–594PubMed
5.
Vignesh AP, Srinivasan R (2015) Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies. Clin Ophthalmol 9:393–397PubMedPubMedCentral
6.
Andonopoulos AP, Drosos AA, Skopouli FN, Acritidis NC, Moutsopoulos HM (1987) Secondary Sjögren’s syndrome in rheumatoid arthritis. J Rheumatol 14:1098–1103PubMed
7.
Choudhary MM, Hajj-Ali RA, Lowder CY (2014) Gender and ocular manifestations of connective tissue diseases and systemic vasculitides. J Ophthalmol 2014:403042PubMedPubMedCentral
8.
Kurt A, Kurt EE, Kilic R, Oktem C, Tuncay F, Erdem HR (2017) Is choroidal thickness related with disease activity and joint damage in patient with rheumatoid arthritis. Bratisl Lek Listy 118:23–27PubMed
9.
Bressler NM (2004) Age-related macular degeneration is the leading cause of blindness. JAMA 291:1900–1901PubMed
10.
Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT, Curletti CR et al (2010) The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res 29:95–112PubMed
11.
Keenan TD, Goldacre R, Goldacre MJ (2015) Associations between age-related macular degeneration, osteoarthritis and rheumatoid arthritis: record linkage study. Retina 35:2613–2618PubMed
12.
13.
Chao-Hsien C, Tse-Yen Y, Cheng-Li L, Chih-Sheng C, Wei-Ming L, Chia-Nan K et al (2016) Dry eye syndrome risks in patients with fibromyalgia: A National Retrospective Cohort Study. Medicine (Baltimore) 95:e2607
14.
Tenkman LR, Price MO, Price FW Jr (2012) Keratoconus onset after age 50. J Refract Surg 28:436–438PubMed
15.
Torricelli AA, Bechara SJ, Wilson SE (2014) Screening of refractive surgery candidates for LASIK and PRK. Cornea 33:1051–1055PubMed
16.
Rahman A, Isenberg DA (2008) Systemic lupus erythematosus. N Engl J Med 358:929–939PubMed
17.
Rico M, Díaz-López JB, Peña J, Oliva-Nacarino P (2016) Latent orbital pseudotumor secondary to systemic lupus erythematosus. Clin Case Rep 4:1065–1067PubMedPubMedCentral
18.
Silpa-archa S, Lee JJ, Foster CS (2016) Ocular manifestations in systemic lupus erythematosus. Br J Ophthalmol 100:135–141PubMed
19.
20.
21.
Mendrinos E, Mavrakanas N, Kiel R, Pournaras CJ (2009) Bilateral combined central retinal artery and vein occlusion in systemic lupus erythematosus resulting in complete blindness. Eye (London) 23:1231–1232
22.
Wu C, Dai R, Dong F, Wang Q (2014) Purtscher-like retinopathy in systemic lupus erythematosus. Am J Ophthalmol 158(1335–1341):e1
23.
Baglio V, Gharbiya M, Balacco-Gabrieli C, Mascaro T, Gangemi C, Di Franco M et al (2011) Choroidopathy in patients with systemic lupus erythematosus with or without nephropathy. J Nephrol 24:522–529PubMed
24.
Cantini F, Nannini C, Cassarà E, Kaloudi O, Niccoli L (2015) Uveitis in Spondyloarthritis: an overview. J Rheumatol Suppl 93:27–29PubMed
25.
Jakob E, Reuland MS, Mackensen F, Harsch N, Fleckenstein M, Lorenz HM et al (2009) Uveitis subtypes in a german interdisciplinary uveitis center-analysis of 1916 patients. J Rheumatol 36:127–136PubMed
26.
Rodriguez A, Akova YA, Pedroza-Seres M, Foster CS (1994) Posterior segment ocular manifestations in patients with HLA-B27-associated uveitis. Ophthalmology 101:1267–1274PubMed
27.
Cailin A (1981) Reiter’s syndrome. In: Kelley WN, Harris ED, Ruddy S, Sledge CB (eds) Textbook of rheumatology. WB Saunders, Philadelphia, pp 1033–1046
28.
Kiss S, Letko E, Qamruddin S, Baltatzis S, Foster CS (2003) Long-term progression, prognosis, and treatment of patients with recurrent ocular manifestations of Reiter’s syndrome. Ophthalmology 110:1764–1769PubMed
29.
Karmiris K, Avgerinos A, Tavernaraki A, Zeglinas C, Karatzas P, Koukouratos T et al (2016) Prevalence and characteristics of extra-intestinal manifestations in a large cohort of Greek patients with inflammatory bowel disease. J Crohns Colitis 10:429–436PubMed
30.
Culver EL, Salmon JF, Frith P, Travis SP (2008) Recurrent posterior scleritis and orbital myositis as extra-intestinal manifestations of Crohn’s disease: case report and systematic literature review. J Crohns Colitis 2:337–342PubMed
31.
Morax V (1893) Formes rares D’Iritis. Ann Oculist 109:368–370
32.
33.
Altan-Yaycioglu R, Akova YA, Kart H, Cetinkaya A, Yilmaz G, Aydin P (2003) Posterior scleritis in psoriatic arthritis. Retina 23:717–719PubMed
34.
Abbouda A, Abicca I, Fabiani C, Scappatura N, Peña-García P, Scrivo R et al (2017) Psoriasis and psoriatic arthritis-related uveitis: different ophthalmological manifestations and ocular inflammation features. Semin Ophthalmol 32:715–720PubMed
35.
D’Ambrosio EM, La Cava M, Tortorella P, Gharbiya M, Campanella M, Iannetti L (2017) Clinical features and complications of the HLA-B27-associated acute anterior uveitis: a metanalysis. Semin Ophthalmol 32:689–701PubMed
36.
Monnet D, Breban M, Hudry C, Dougados M, Brézin AP (2004) Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases. Ophthalmology 111:802–809PubMed
37.
Menkes CJ, Job-Deslandre C, Feldmann JL (1984) Juvenile-onset ankylosing spondylitis. Sem Hop 60:543–546PubMed
38.
39.
Stucchi CA, Geiser JD (1967) Manifestations oculars de la scleroderme generalisee. Doc Ophthalmol 22:72–110PubMed
40.
Nizam S, Johnstone A, Green M, Gough A (2009) Necrotising scleritis and connective tissue disease-three cases and a review. Clin Rheumatol 28:339–341PubMed
41.
Gomes Bde A, Santhiago MR, Magalhães P, Kara-Junior N, Azevedo MN, Moraes HV Jr (2011) Ocular findings in patients with systemic sclerosis. Clinics (Sao Paulo) 66:379–385
42.
Şahin M, Yüksel H, Şahin A, Cingü AK, Türkcü FM, Kaya S et al (2017) Evaluation of the anterior segment parameters of the patients with scleroderma. Ocul Immunol Inflamm 25:233–238PubMed
43.
Rentka A, Nagy A, Harsfalvi J, Szucs G, Szekanecz Z, Gesztelyi R et al (2017) Association between objective signs and subjective symptoms of dry eye disease in patients with systemic sclerosis. Rheumatol Int 37:1835–1845PubMed
44.
Agatston HJ (1953) Scleroderma with retinopathy. Am J Ophthalmol 36:120–121PubMed
45.
Ashton N, Coomes EN, Garner A, Oliver DO (1968) Retinopathy due to progressive systemic sclerosis. J Pathol Bacteriol 96:259–268PubMed
46.
Tuft SJ, Watson PG (1991) Progression of scleral disease. Ophthalmology 98:467–471PubMed
47.
Faez S, Lobo AM, Unizony SH, Stone JH, Papaliodis GN, Sobrin L (2016) Ocular inflammatory disease in patients with polymyalgia rheumatica: a case series and review of the literature. Clin Rheumatol 35:251–258PubMed
48.
Clark GC, Moloney G, Sutton G (2010) Ophthalmic presentation of Wegener’s granulomatosis on a background of polymyalgia rheumatica. Clin Exp Ophthalmol 38:65–67PubMed
Metadata
Title
Ocular manifestations of rheumatic diseases
Authors
Adam Kemeny-Beke
Peter Szodoray
Publication date
01-02-2020

Other articles of this Issue 2/2020

International Ophthalmology 2/2020 Go to the issue

Original Paper

CDKN2A, CDK1, and CCNE1 overexpression in sebaceous gland carcinoma of eyelid

Original Paper

Sagittal height differences of disposable soft contact lenses

Original Paper

Biofeedback fixation training method for improving eccentric vision in patients with loss of foveal function secondary to different maculopathies

Original Paper

Mining the proliferative diabetic retinopathy-associated genes and pathways by integrated bioinformatic analysis

Original Paper

Real-life experience of using brinzolamide/brimonidine fixed drop combination in a tertiary glaucoma centre

Original Paper

Intermediate filaments in the medial rectus muscles in patients with concomitant exotropia