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Open Access 01-01-2019

Understanding non-response to cardiac resynchronisation therapy: common problems and potential solutions

Authors: Benjamin J. Sieniewicz, Justin Gould, Bradley Porter, Baldeep S. Sidhu, Thomas Teall, Jessica Webb, Gerarld Carr-White, Christopher A. Rinaldi

Published in: Heart Failure Reviews | Issue 1/2019

Abstract

Heart failure is a complex clinical syndrome associated with a significant morbidity and mortality burden. Reductions in left ventricular (LV) function trigger adaptive mechanisms, leading to structural changes within the LV and the potential development of dyssynchronous ventricular activation. This is the substrate targeted during cardiac resynchronisation therapy (CRT); however, around 30–50% of patients do not experience benefit from this treatment. Non-response occurs as a result of pre-implant, peri-implant and post implant factors but the technical constraints of traditional, transvenous epicardial CRT mean they can be challenging to overcome. In an effort to improve response, novel alternative methods of CRT delivery have been developed and of these endocardial pacing, where the LV is stimulated from inside the LV cavity, appears the most promising.

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Title: Understanding non-response to cardiac resynchronisation therapy: common problems and potential solutions
Authors: Benjamin J. Sieniewicz
Justin Gould
Bradley Porter
Baldeep S. Sidhu
Thomas Teall
Jessica Webb
Gerarld Carr-White
Christopher A. Rinaldi
Publication date: 01-01-2019
Publisher: Springer US
Published in: Heart Failure Reviews / Issue 1/2019
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-018-9734-8

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Cell-based therapies for the treatment of myocardial infarction: lessons from cardiac regeneration and repair mechanisms in non-human vertebrates

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