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Published in: Heart Failure Reviews 1/2019

01-01-2019

Autonomic nervous system in Takotsubo syndrome

Authors: Sonia Borodzicz, Katarzyna Czarzasta, Grzegorz Opolski, Agnieszka Cudnoch-Jędrzejewska

Published in: Heart Failure Reviews | Issue 1/2019

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Abstract

Takotsubo syndrome (TTS) is an acute and usually reversible heart failure syndrome with symptoms resembling acute myocardial infarction, however, without obstruction of coronary arteries. In the majority of cases, TTS is preceded by emotional or physical stress and the disease concerns mainly postmenopausal women. Although several hypotheses have been introduced, the pathogenesis of TTS is controversial and still remains to be determined. As reported in recent studies, the role of the autonomic nervous system (ANS) seems to be pivotal in the pathogenesis of TTS. Therefore, the aim of this article is to summarize and discuss the current knowledge of the pathogenesis of TTS with a special focus on the ANS.
Literature
1.
go back to reference Lyon AR, Bossone E, Schneider B, Sechtem U, Citro R, Underwood SR, Sheppard MN, Figtree GA, Parodi G, Akashi YJ, Ruschitzka F, Filippatos G, Mebazaa A, Omerovic E (2016) Current state of knowledge on Takotsubo syndrome: a position statement from the taskforce on Takotsubo syndrome of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 18(1):8–27. https://doi.org/10.1002/ejhf.424 PubMedCrossRef Lyon AR, Bossone E, Schneider B, Sechtem U, Citro R, Underwood SR, Sheppard MN, Figtree GA, Parodi G, Akashi YJ, Ruschitzka F, Filippatos G, Mebazaa A, Omerovic E (2016) Current state of knowledge on Takotsubo syndrome: a position statement from the taskforce on Takotsubo syndrome of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 18(1):8–27. https://​doi.​org/​10.​1002/​ejhf.​424 PubMedCrossRef
5.
go back to reference Sato HTH, Umemura T, Dote K, Ishihara M (1990) Tako-tsubo-like left ventricular dysfunction due to multivessel coronary spasm. In: Kodama K, Haze K, Hori M (eds) Clinical aspect of myocardial injury: from ischemia to heart failure. Kagakuhyoronsha Publishing Co, Tokyo, Japan, pp 56–64 Sato HTH, Umemura T, Dote K, Ishihara M (1990) Tako-tsubo-like left ventricular dysfunction due to multivessel coronary spasm. In: Kodama K, Haze K, Hori M (eds) Clinical aspect of myocardial injury: from ischemia to heart failure. Kagakuhyoronsha Publishing Co, Tokyo, Japan, pp 56–64
6.
go back to reference Dote K, Sato H, Tateishi H, Uchida T, Ishihara M (1991) Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases. J Cardiol 21(2):203–214PubMed Dote K, Sato H, Tateishi H, Uchida T, Ishihara M (1991) Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases. J Cardiol 21(2):203–214PubMed
8.
go back to reference Sharkey SW, Lesser JR, Maron MS, Maron BJ (2011) Why not just call it tako-tsubo cardiomyopathy. J Am Coll Cardiol 57(13):1496–1497PubMedCrossRef Sharkey SW, Lesser JR, Maron MS, Maron BJ (2011) Why not just call it tako-tsubo cardiomyopathy. J Am Coll Cardiol 57(13):1496–1497PubMedCrossRef
9.
go back to reference Haghi D, Athanasiadis A, Papavassiliu T, Suselbeck T, Fluechter S, Mahrholdt H, Borggrefe M, Sechtem U (2006) Right ventricular involvement in Takotsubo cardiomyopathy. Eur Heart J 27(20):2433–2439PubMedCrossRef Haghi D, Athanasiadis A, Papavassiliu T, Suselbeck T, Fluechter S, Mahrholdt H, Borggrefe M, Sechtem U (2006) Right ventricular involvement in Takotsubo cardiomyopathy. Eur Heart J 27(20):2433–2439PubMedCrossRef
10.
go back to reference Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Mitsuba N, Hata T, Nakama Y, Kisaka T, Kijima Y (2005) Takotsubo-like transient biventricular dysfunction with pressure gradients. Intern Med 44(7):727–732PubMedCrossRef Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Mitsuba N, Hata T, Nakama Y, Kisaka T, Kijima Y (2005) Takotsubo-like transient biventricular dysfunction with pressure gradients. Intern Med 44(7):727–732PubMedCrossRef
11.
go back to reference Novak G, Kross K, Follmer K, Brofferio A, Shirani J (2007) Transient biventricular apical ballooning: a unique presentation of the “broken heart”. Clin Cardiol 30(7):355–358PubMedPubMedCentralCrossRef Novak G, Kross K, Follmer K, Brofferio A, Shirani J (2007) Transient biventricular apical ballooning: a unique presentation of the “broken heart”. Clin Cardiol 30(7):355–358PubMedPubMedCentralCrossRef
12.
go back to reference Abdulla I, Kay S, Mussap C, Nelson G, Rasmussen H, Hansen P, Ward M (2006) Apical sparing in tako-tsubo cardiomyopathy. Intern Med J 36(7):414–418PubMedCrossRef Abdulla I, Kay S, Mussap C, Nelson G, Rasmussen H, Hansen P, Ward M (2006) Apical sparing in tako-tsubo cardiomyopathy. Intern Med J 36(7):414–418PubMedCrossRef
13.
go back to reference Schneider B, Sechtem U (2016) Influence of age and gender in Takotsubo syndrome. Heart Fail Clin 12(4):521–530PubMedCrossRef Schneider B, Sechtem U (2016) Influence of age and gender in Takotsubo syndrome. Heart Fail Clin 12(4):521–530PubMedCrossRef
14.
go back to reference Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschope C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Bohm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Luscher TF (2015) Clinical features and outcomes of Takotsubo (stress) cardiomyopathy. N Engl J Med 373(10):929–938. https://doi.org/10.1056/NEJMoa1406761 PubMedCrossRef Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschope C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Bohm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Luscher TF (2015) Clinical features and outcomes of Takotsubo (stress) cardiomyopathy. N Engl J Med 373(10):929–938. https://​doi.​org/​10.​1056/​NEJMoa1406761 PubMedCrossRef
16.
go back to reference Wittstein IS (2016) The sympathetic nervous system in the pathogenesis of Takotsubo syndrome. Heart Fail Clin 12(4):485–498PubMedCrossRef Wittstein IS (2016) The sympathetic nervous system in the pathogenesis of Takotsubo syndrome. Heart Fail Clin 12(4):485–498PubMedCrossRef
19.
go back to reference Aoki Y, Kodera S, Watanabe T, Miyauchi Y, Kanda J, Ooe K (2016) Autopsy findings in takotsubo cardiomyopathy with special reference to the autonomic nervous system. Int J Cardiol 203:236–237PubMedCrossRef Aoki Y, Kodera S, Watanabe T, Miyauchi Y, Kanda J, Ooe K (2016) Autopsy findings in takotsubo cardiomyopathy with special reference to the autonomic nervous system. Int J Cardiol 203:236–237PubMedCrossRef
20.
go back to reference Shams Y (2016) Clinical features and outcome of epinephrine-induced takotsubo syndrome: analysis of 33 published cases. Cardiovasc Revasc Med 17(7):450–455CrossRef Shams Y (2016) Clinical features and outcome of epinephrine-induced takotsubo syndrome: analysis of 33 published cases. Cardiovasc Revasc Med 17(7):450–455CrossRef
21.
go back to reference Elikowski W, Małek-Elikowska M, Karoń J, Mrozińska M, Baszko A, Horbacka K (2017) Takotsubo cardiomyopathy after intravenous epinephrine administration following cardiac arrest provoked by pneumoperitoneum-a case report. Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego 42(250):165–169 Elikowski W, Małek-Elikowska M, Karoń J, Mrozińska M, Baszko A, Horbacka K (2017) Takotsubo cardiomyopathy after intravenous epinephrine administration following cardiac arrest provoked by pneumoperitoneum-a case report. Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego 42(250):165–169
22.
go back to reference Nassif J, Nahouli H, Khali A, Mikhael E, Gharzeddine W, Ghaziri G (2017) Epinephrine-induced Takotsubo cardiomyopathy during laparoscopic myomectomy: case report and review of the literature. J Minim Invasive Gynecol 24:1037–1039PubMedCrossRef Nassif J, Nahouli H, Khali A, Mikhael E, Gharzeddine W, Ghaziri G (2017) Epinephrine-induced Takotsubo cardiomyopathy during laparoscopic myomectomy: case report and review of the literature. J Minim Invasive Gynecol 24:1037–1039PubMedCrossRef
23.
go back to reference Kajander OA, Virtanen MP, Sclarovsky S, Nikus KC (2013) Iatrogenic inverted takotsubo syndrome following intravenous adrenaline injections for an allergic reaction. Int J Cardiol 165(1):e3–e5PubMedCrossRef Kajander OA, Virtanen MP, Sclarovsky S, Nikus KC (2013) Iatrogenic inverted takotsubo syndrome following intravenous adrenaline injections for an allergic reaction. Int J Cardiol 165(1):e3–e5PubMedCrossRef
24.
go back to reference Collen J, Bimson W, Devine P (2008) A variant of Takotsubo cardiomyopathy: a rare complication in the electrophysiology lab. J Invasive Cardiol 20(11):E310–E313PubMed Collen J, Bimson W, Devine P (2008) A variant of Takotsubo cardiomyopathy: a rare complication in the electrophysiology lab. J Invasive Cardiol 20(11):E310–E313PubMed
25.
go back to reference Winogradow J, Geppert G, Reinhard W, Resch M, Radke P, Hengstenberg C (2011) Tako-tsubo cardiomyopathy after administration of intravenous epinephrine during an anaphylactic reaction. Int J Cardiol 147(2):309–311PubMedCrossRef Winogradow J, Geppert G, Reinhard W, Resch M, Radke P, Hengstenberg C (2011) Tako-tsubo cardiomyopathy after administration of intravenous epinephrine during an anaphylactic reaction. Int J Cardiol 147(2):309–311PubMedCrossRef
26.
go back to reference Ghanim D, Adler Z, Qarawani D, Kusniec F, Amir O, Carasso S (2015) Takotsubo cardiomyopathy caused by epinephrine-treated bee sting anaphylaxis: a case report. J Med Case Rep 9(1):247PubMedPubMedCentralCrossRef Ghanim D, Adler Z, Qarawani D, Kusniec F, Amir O, Carasso S (2015) Takotsubo cardiomyopathy caused by epinephrine-treated bee sting anaphylaxis: a case report. J Med Case Rep 9(1):247PubMedPubMedCentralCrossRef
27.
go back to reference Kido K, Guglin M (2017) Drug-induced Takotsubo cardiomyopathy. J Cardiovasc Pharmacol Ther 1074248417708618 Kido K, Guglin M (2017) Drug-induced Takotsubo cardiomyopathy. J Cardiovasc Pharmacol Ther 1074248417708618
28.
go back to reference Redfors B, Ali A, Shao Y, Lundgren J, Gan L-M, Omerovic E (2014) Different catecholamines induce different patterns of takotsubo-like cardiac dysfunction in an apparently afterload dependent manner. Int J Cardiol 174(2):330–336PubMedCrossRef Redfors B, Ali A, Shao Y, Lundgren J, Gan L-M, Omerovic E (2014) Different catecholamines induce different patterns of takotsubo-like cardiac dysfunction in an apparently afterload dependent manner. Int J Cardiol 174(2):330–336PubMedCrossRef
29.
go back to reference Shao Y, Redfors B, Täng MS, Möllmann H, Troidl C, Szardien S, Hamm C, Nef H, Borén J, Omerovic E (2013) Novel rat model reveals important roles of β-adrenoreceptors in stress-induced cardiomyopathy. Int J Cardiol 168(3):1943–1950PubMedCrossRef Shao Y, Redfors B, Täng MS, Möllmann H, Troidl C, Szardien S, Hamm C, Nef H, Borén J, Omerovic E (2013) Novel rat model reveals important roles of β-adrenoreceptors in stress-induced cardiomyopathy. Int J Cardiol 168(3):1943–1950PubMedCrossRef
30.
go back to reference Redfors B, Shao Y, Wikström J, Lyon AR, Oldfors A, Gan L-M, Omerovic E (2013) Contrast echocardiography reveals apparently normal coronary perfusion in a rat model of stress-induced (Takotsubo) cardiomyopathy. Eur Heart J Cardiovasc Imaging 15(2):152–157PubMedCrossRef Redfors B, Shao Y, Wikström J, Lyon AR, Oldfors A, Gan L-M, Omerovic E (2013) Contrast echocardiography reveals apparently normal coronary perfusion in a rat model of stress-induced (Takotsubo) cardiomyopathy. Eur Heart J Cardiovasc Imaging 15(2):152–157PubMedCrossRef
31.
go back to reference Redfors B, Oras J, Shao Y, Seemann-Lodding H, Ricksten S-E, Omerovic E (2014) Cardioprotective effects of isoflurane in a rat model of stress-induced cardiomyopathy (takotsubo). Int J Cardiol 176(3):815–821PubMedCrossRef Redfors B, Oras J, Shao Y, Seemann-Lodding H, Ricksten S-E, Omerovic E (2014) Cardioprotective effects of isoflurane in a rat model of stress-induced cardiomyopathy (takotsubo). Int J Cardiol 176(3):815–821PubMedCrossRef
32.
go back to reference Sachdeva J, Dai W, Kloner RA (2014) Functional and histological assessment of an experimental model of Takotsubo’s cardiomyopathy. J Am Heart Assoc 3(3):e000921PubMedPubMedCentralCrossRef Sachdeva J, Dai W, Kloner RA (2014) Functional and histological assessment of an experimental model of Takotsubo’s cardiomyopathy. J Am Heart Assoc 3(3):e000921PubMedPubMedCentralCrossRef
33.
go back to reference Kołodzińska A, Czarzasta K, Szczepankiewicz B, Główczyńska R, Fojt A, Ilczuk T, Budnik M, Krasuski K, Folta M, Cudnoch-Jędrzejewska A (2018) Toll-like receptor expression and apoptosis morphological patterns in female rat hearts with takotsubo syndrome induced by isoprenaline. Life Sci 199:112–121PubMedCrossRef Kołodzińska A, Czarzasta K, Szczepankiewicz B, Główczyńska R, Fojt A, Ilczuk T, Budnik M, Krasuski K, Folta M, Cudnoch-Jędrzejewska A (2018) Toll-like receptor expression and apoptosis morphological patterns in female rat hearts with takotsubo syndrome induced by isoprenaline. Life Sci 199:112–121PubMedCrossRef
34.
go back to reference Abraham J, Mudd JO, Kapur N, Klein K, Champion HC, Wittstein IS (2009) Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. J Am Coll Cardiol 53(15):1320–1325PubMedCrossRef Abraham J, Mudd JO, Kapur N, Klein K, Champion HC, Wittstein IS (2009) Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. J Am Coll Cardiol 53(15):1320–1325PubMedCrossRef
35.
go back to reference Randall WC, Szentivanyi M, Pace JB, Wechsler JS, Kaye MP (1968) Patterns of sympathetic nerve projections onto the canine heart. Circ Res 22(3):315–323PubMedCrossRef Randall WC, Szentivanyi M, Pace JB, Wechsler JS, Kaye MP (1968) Patterns of sympathetic nerve projections onto the canine heart. Circ Res 22(3):315–323PubMedCrossRef
36.
go back to reference Kawano H, Okada R, Yano K (2003) Histological study on the distribution of autonomic nerves in the human heart. Heart Vessel 18(1):32–39CrossRef Kawano H, Okada R, Yano K (2003) Histological study on the distribution of autonomic nerves in the human heart. Heart Vessel 18(1):32–39CrossRef
37.
go back to reference Kimura K, Ieda M, Fukuda K (2012) Development, maturation, and transdifferentiation of cardiac sympathetic nerves. Circ Res 110(2):325–336PubMedCrossRef Kimura K, Ieda M, Fukuda K (2012) Development, maturation, and transdifferentiation of cardiac sympathetic nerves. Circ Res 110(2):325–336PubMedCrossRef
38.
go back to reference Vincentz JW, Rubart M, Firulli AB (2012) Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease. Pediatr Cardiol 33(6):923–928PubMedPubMedCentralCrossRef Vincentz JW, Rubart M, Firulli AB (2012) Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease. Pediatr Cardiol 33(6):923–928PubMedPubMedCentralCrossRef
39.
go back to reference Zaroff JG, Rordorf GA, Ogilvy CS, Picard MH (2000) Regional patterns of left ventricular systolic dysfunction after subarachnoid hemorrhage: evidence for neurally mediated cardiac injury. J Am Soc Echocardiogr 13(8):774–779PubMedCrossRef Zaroff JG, Rordorf GA, Ogilvy CS, Picard MH (2000) Regional patterns of left ventricular systolic dysfunction after subarachnoid hemorrhage: evidence for neurally mediated cardiac injury. J Am Soc Echocardiogr 13(8):774–779PubMedCrossRef
40.
go back to reference Vriz O, Minisini R, Citro R, Guerra V, Zito C, De Luca G, Pavan D, Pirisi M, Limongelli G, Bossone E (2011) Analysis of β1 and β2-adrenergic receptors polymorphism in patients with apical ballooning cardiomyopathy. Acta Cardiol 66(6):787–790PubMedCrossRef Vriz O, Minisini R, Citro R, Guerra V, Zito C, De Luca G, Pavan D, Pirisi M, Limongelli G, Bossone E (2011) Analysis of β1 and β2-adrenergic receptors polymorphism in patients with apical ballooning cardiomyopathy. Acta Cardiol 66(6):787–790PubMedCrossRef
41.
go back to reference Mason DA, Moore JD, Green SA, Liggett SB (1999) A gain-of-function polymorphism in a G-protein coupling domain of the human β1-adrenergic receptor. J Biol Chem 274(18):12670–12674PubMedCrossRef Mason DA, Moore JD, Green SA, Liggett SB (1999) A gain-of-function polymorphism in a G-protein coupling domain of the human β1-adrenergic receptor. J Biol Chem 274(18):12670–12674PubMedCrossRef
42.
go back to reference Sandilands A, O’shaughnessy K, Brown M (2003) Greater inotropic and cyclic AMP responses evoked by noradrenaline through Arg389 β1-adrenoceptors versus Gly389 β1-adrenoceptors in isolated human atrial myocardium. Br J Pharmacol 138(2):386–392PubMedPubMedCentralCrossRef Sandilands A, O’shaughnessy K, Brown M (2003) Greater inotropic and cyclic AMP responses evoked by noradrenaline through Arg389 β1-adrenoceptors versus Gly389 β1-adrenoceptors in isolated human atrial myocardium. Br J Pharmacol 138(2):386–392PubMedPubMedCentralCrossRef
43.
go back to reference Bruck H, Leineweber K, Temme T, Weber M, Heusch G, Philipp T, Brodde O-E (2005) The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. J Am Coll Cardiol 46(11):2111–2115PubMedCrossRef Bruck H, Leineweber K, Temme T, Weber M, Heusch G, Philipp T, Brodde O-E (2005) The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. J Am Coll Cardiol 46(11):2111–2115PubMedCrossRef
44.
go back to reference Sharkey SW, Maron BJ, Nelson P, Parpart M, Maron MS, Bristow MR (2009) Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy. J Cardiol 53(1):53–57PubMedCrossRef Sharkey SW, Maron BJ, Nelson P, Parpart M, Maron MS, Bristow MR (2009) Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy. J Cardiol 53(1):53–57PubMedCrossRef
45.
go back to reference Spinelli L, Trimarco V, Di Marino S, Marino M, Iaccarino G, Trimarco B (2010) L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome. Eur J Heart Fail 12(1):13–16PubMedCrossRef Spinelli L, Trimarco V, Di Marino S, Marino M, Iaccarino G, Trimarco B (2010) L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome. Eur J Heart Fail 12(1):13–16PubMedCrossRef
46.
go back to reference Figtree GA, Bagnall RD, Abdulla I, Buchholz S, Galougahi KK, Yan W, Tan T, Neil C, Horowitz JD, Semsarian C, Ward MR (2013) No association of G-protein-coupled receptor kinase 5 or beta-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort. Eur J Heart Fail 15(7):730–733. https://doi.org/10.1093/eurjhf/hft040 PubMedCrossRef Figtree GA, Bagnall RD, Abdulla I, Buchholz S, Galougahi KK, Yan W, Tan T, Neil C, Horowitz JD, Semsarian C, Ward MR (2013) No association of G-protein-coupled receptor kinase 5 or beta-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort. Eur J Heart Fail 15(7):730–733. https://​doi.​org/​10.​1093/​eurjhf/​hft040 PubMedCrossRef
47.
48.
go back to reference Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC (2005) Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352(6):539–548PubMedCrossRef Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC (2005) Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352(6):539–548PubMedCrossRef
49.
go back to reference Kume T, Kawamoto T, Okura H, Toyota E, Neishi Y, Watanabe N, Hayashida A, Okahashi N, Yoshimura Y, Saito K (2008) Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunction. Circ J 72(1):106–108PubMedCrossRef Kume T, Kawamoto T, Okura H, Toyota E, Neishi Y, Watanabe N, Hayashida A, Okahashi N, Yoshimura Y, Saito K (2008) Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunction. Circ J 72(1):106–108PubMedCrossRef
50.
go back to reference Morel O, Sauer F, Imperiale A, Cimarelli S, Blondet C, Jesel L, Trinh A, De Poli F, Ohlmann P, Constantinesco A (2009) Importance of inflammation and neurohumoral activation in Takotsubo cardiomyopathy. J Card Fail 15(3):206–213PubMedCrossRef Morel O, Sauer F, Imperiale A, Cimarelli S, Blondet C, Jesel L, Trinh A, De Poli F, Ohlmann P, Constantinesco A (2009) Importance of inflammation and neurohumoral activation in Takotsubo cardiomyopathy. J Card Fail 15(3):206–213PubMedCrossRef
51.
go back to reference Shams Y, Henareh L (2015) Plasma catecholamine levels in patients with takotsubo syndrome: implications for the pathogenesis of the disease. Int J Cardiol 181:35–38CrossRef Shams Y, Henareh L (2015) Plasma catecholamine levels in patients with takotsubo syndrome: implications for the pathogenesis of the disease. Int J Cardiol 181:35–38CrossRef
52.
go back to reference Akashi Y, Barbaro G, Sakurai T, Nakazawa K, Miyake F (2007) Cardiac autonomic imbalance in patients with reversible ventricular dysfunction takotsubo cardiomyopathy. Journal of the Association of Physicians 100(6):335–343CrossRef Akashi Y, Barbaro G, Sakurai T, Nakazawa K, Miyake F (2007) Cardiac autonomic imbalance in patients with reversible ventricular dysfunction takotsubo cardiomyopathy. Journal of the Association of Physicians 100(6):335–343CrossRef
53.
go back to reference Madhavan M, Borlaug BA, Lerman A, Rihal CS, Prasad A (2009) Stress hormone and circulating biomarker profile of apical ballooning syndrome (Takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels. Heart 95(17):1436–1441PubMedCrossRef Madhavan M, Borlaug BA, Lerman A, Rihal CS, Prasad A (2009) Stress hormone and circulating biomarker profile of apical ballooning syndrome (Takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels. Heart 95(17):1436–1441PubMedCrossRef
54.
go back to reference Pinkham MI, Barrett CJ (2015) Estradiol alters the chemosensitive cardiac afferent reflex in female rats by augmenting sympathoinhibition and attenuating sympathoexcitation. Clin Exp Pharmacol Physiol 42(6):622–631PubMedCrossRef Pinkham MI, Barrett CJ (2015) Estradiol alters the chemosensitive cardiac afferent reflex in female rats by augmenting sympathoinhibition and attenuating sympathoexcitation. Clin Exp Pharmacol Physiol 42(6):622–631PubMedCrossRef
55.
go back to reference Saleh TM, Connell BJ (2000) 17β-Estradiol modulates baroreflex sensitivity and autonomic tone of female rats. J Auton Nerv Syst 80(3):148–161PubMedCrossRef Saleh TM, Connell BJ (2000) 17β-Estradiol modulates baroreflex sensitivity and autonomic tone of female rats. J Auton Nerv Syst 80(3):148–161PubMedCrossRef
56.
go back to reference Gautam S, Shankar N, Tandon OP, Goel N (2011) Comparison of cardiac autonomic functions among postmenopausal women with and without hormone replacement therapy, and premenopausal women Gautam S, Shankar N, Tandon OP, Goel N (2011) Comparison of cardiac autonomic functions among postmenopausal women with and without hormone replacement therapy, and premenopausal women
57.
go back to reference Hart EC, Charkoudian N, Joyner MJ, Barnes JN, Curry TB, Casey DP (2013) Relationship between sympathetic nerve activity and aortic wave reflection characteristics in postmenopausal women. Menopause (New York, NY) 20(9):967CrossRef Hart EC, Charkoudian N, Joyner MJ, Barnes JN, Curry TB, Casey DP (2013) Relationship between sympathetic nerve activity and aortic wave reflection characteristics in postmenopausal women. Menopause (New York, NY) 20(9):967CrossRef
58.
go back to reference Perseguini NM, de Medeiros Takahashi AC, Milan JC, Dos Santos PR, Neves VFC, Borghi-Silva A, Silva E, Montano N, Porta A, Catai AM (2014) Effect of hormone replacement therapy on cardiac autonomic modulation. Clin Auton Res 24(2):63–70PubMedCrossRef Perseguini NM, de Medeiros Takahashi AC, Milan JC, Dos Santos PR, Neves VFC, Borghi-Silva A, Silva E, Montano N, Porta A, Catai AM (2014) Effect of hormone replacement therapy on cardiac autonomic modulation. Clin Auton Res 24(2):63–70PubMedCrossRef
59.
go back to reference Lavi S, Nevo O, Thaler I, Rosenfeld R, Dayan L, Hirshoren N, Gepstein L, Jacob G (2007) Effect of aging on the cardiovascular regulatory systems in healthy women. Am J Phys Regul Integr Comp Phys 292(2):R788–R793 Lavi S, Nevo O, Thaler I, Rosenfeld R, Dayan L, Hirshoren N, Gepstein L, Jacob G (2007) Effect of aging on the cardiovascular regulatory systems in healthy women. Am J Phys Regul Integr Comp Phys 292(2):R788–R793
60.
go back to reference Giavarini A, Chedid A, Bobrie G, Plouin P-F, Hagège A, Amar L (2013) Acute catecholamine cardiomyopathy in patients with phaeochromocytoma or functional paraganglioma. Heart 99(19):1438–1444PubMedCrossRef Giavarini A, Chedid A, Bobrie G, Plouin P-F, Hagège A, Amar L (2013) Acute catecholamine cardiomyopathy in patients with phaeochromocytoma or functional paraganglioma. Heart 99(19):1438–1444PubMedCrossRef
61.
go back to reference Brugts JJ, van Gent M, Caliskan K, Kofflard MJ (2014) Repetitive stress-induced cardiomyopathy due to inverted Takotsubo in exaggerated sympathetic stimulation by pheochromocytoma. Eur Heart J Cardiovasc Imaging 16(1):113–113PubMedCrossRef Brugts JJ, van Gent M, Caliskan K, Kofflard MJ (2014) Repetitive stress-induced cardiomyopathy due to inverted Takotsubo in exaggerated sympathetic stimulation by pheochromocytoma. Eur Heart J Cardiovasc Imaging 16(1):113–113PubMedCrossRef
62.
go back to reference Gagnon N, Mansour S, Bitton Y, Bourdeau I (2017) Takotsubo-like cardiomyopathy in a large cohort of patients with pheochromocytoma and paraganglioma. Endocr Pract 23:1178–1192PubMedCrossRef Gagnon N, Mansour S, Bitton Y, Bourdeau I (2017) Takotsubo-like cardiomyopathy in a large cohort of patients with pheochromocytoma and paraganglioma. Endocr Pract 23:1178–1192PubMedCrossRef
63.
go back to reference Coupez E, Eschalier R, Pereira B, Pierrard R, Souteyrand G, Clerfond G, Citron B, Lusson J-R, Mansencal N, Motreff P (2014) A single pathophysiological pathway in Takotsubo cardiomyopathy: catecholaminergic stress. Arch Cardiovasc Dis 107(4):245–252PubMedCrossRef Coupez E, Eschalier R, Pereira B, Pierrard R, Souteyrand G, Clerfond G, Citron B, Lusson J-R, Mansencal N, Motreff P (2014) A single pathophysiological pathway in Takotsubo cardiomyopathy: catecholaminergic stress. Arch Cardiovasc Dis 107(4):245–252PubMedCrossRef
64.
go back to reference Finsterer J, Wahbi K (2014) CNS disease triggering Takotsubo stress cardiomyopathy. Int J Cardiol 177(2):322–329PubMedCrossRef Finsterer J, Wahbi K (2014) CNS disease triggering Takotsubo stress cardiomyopathy. Int J Cardiol 177(2):322–329PubMedCrossRef
65.
go back to reference Porto I, Della Bona R, Leo A, Proietti R, Pieroni M, Caltagirone C, Spalletta G, Bolognese L, Cravello L (2013) Stress cardiomyopathy (tako-tsubo) triggered by nervous system diseases: a systematic review of the reported cases. Int J Cardiol 167(6):2441–2448PubMedCrossRef Porto I, Della Bona R, Leo A, Proietti R, Pieroni M, Caltagirone C, Spalletta G, Bolognese L, Cravello L (2013) Stress cardiomyopathy (tako-tsubo) triggered by nervous system diseases: a systematic review of the reported cases. Int J Cardiol 167(6):2441–2448PubMedCrossRef
66.
go back to reference Khurana RK (2008) Takotsubo cardiomyopathy in a patient with postural tachycardia syndrome. Clin Auton Res 18(1):43–47PubMedCrossRef Khurana RK (2008) Takotsubo cardiomyopathy in a patient with postural tachycardia syndrome. Clin Auton Res 18(1):43–47PubMedCrossRef
67.
go back to reference Harris ZM, Alonso A, Kennedy TP (2016) Adrenergic inhibition with dexmedetomidine to treat stress cardiomyopathy during alcohol withdrawal: a case report and literature review. Case reports in critical care 2016, 1, 9 Harris ZM, Alonso A, Kennedy TP (2016) Adrenergic inhibition with dexmedetomidine to treat stress cardiomyopathy during alcohol withdrawal: a case report and literature review. Case reports in critical care 2016, 1, 9
68.
go back to reference Sarcon A, Ghadri J-R, Wong G, Lüscher TF, Templin C, Amsterdam E (2013) Takotsubo cardiomyopathy associated with opiate withdrawal. QJM: An International Journal of Medicine 107(4):301–302CrossRef Sarcon A, Ghadri J-R, Wong G, Lüscher TF, Templin C, Amsterdam E (2013) Takotsubo cardiomyopathy associated with opiate withdrawal. QJM: An International Journal of Medicine 107(4):301–302CrossRef
69.
go back to reference Arora S, Alfayoumi F, Srinivasan V (2006) Transient left ventricular apical ballooning after cocaine use: is catecholamine cardiotoxicity the pathologic link? Mayo Clin Proc 81(6):829-32 Arora S, Alfayoumi F, Srinivasan V (2006) Transient left ventricular apical ballooning after cocaine use: is catecholamine cardiotoxicity the pathologic link? Mayo Clin Proc 81(6):829-32
70.
go back to reference Sharp RP, Welch EB (2011) Takotsubo cardiomyopathy as a complication of electroconvulsive therapy. Ann Pharmacother 45(12):1559–1565PubMedCrossRef Sharp RP, Welch EB (2011) Takotsubo cardiomyopathy as a complication of electroconvulsive therapy. Ann Pharmacother 45(12):1559–1565PubMedCrossRef
71.
go back to reference Madias JE (2016) Low prevalence of diabetes mellitus in patients with Takotsubo syndrome: a plausible ‘protective’ effect with pathophysiologic connotations. Eur Heart J Acute Cardiovasc Care 5(2):164–170PubMedCrossRef Madias JE (2016) Low prevalence of diabetes mellitus in patients with Takotsubo syndrome: a plausible ‘protective’ effect with pathophysiologic connotations. Eur Heart J Acute Cardiovasc Care 5(2):164–170PubMedCrossRef
72.
go back to reference Madias JE (2016) Details about diabetes mellitus in reported patients with Takotsubo syndrome, and its importance in unraveling the pathophysiology of the disease. Int J Cardiol 209:70–71PubMedCrossRef Madias JE (2016) Details about diabetes mellitus in reported patients with Takotsubo syndrome, and its importance in unraveling the pathophysiology of the disease. Int J Cardiol 209:70–71PubMedCrossRef
73.
go back to reference Madias JE (2016) An animal model of diabetic peripheral neuropathy and the pathophysiology of takotsubo syndrome: a proposal of an experiment. Int J Cardiol 222:882–884PubMedCrossRef Madias JE (2016) An animal model of diabetic peripheral neuropathy and the pathophysiology of takotsubo syndrome: a proposal of an experiment. Int J Cardiol 222:882–884PubMedCrossRef
74.
go back to reference Burgdorf C, Richardt D, Kurz T, Adler S, Nötzold A, Kraatz E, Sievers H, Richardt G (2003) Norepinephrine release is reduced in cardiac tissue of type 2 diabetic patients. Diabetologia 46(4):520–523PubMedCrossRef Burgdorf C, Richardt D, Kurz T, Adler S, Nötzold A, Kraatz E, Sievers H, Richardt G (2003) Norepinephrine release is reduced in cardiac tissue of type 2 diabetic patients. Diabetologia 46(4):520–523PubMedCrossRef
75.
go back to reference Stiermaier T, Moeller C, Oehler K, Desch S, Graf T, Eitel C, Vonthein R, Schuler G, Thiele H, Eitel I (2016) Long-term excess mortality in Takotsubo cardiomyopathy: predictors, causes and clinical consequences. Eur J Heart Fail 18(6):650–656PubMedCrossRef Stiermaier T, Moeller C, Oehler K, Desch S, Graf T, Eitel C, Vonthein R, Schuler G, Thiele H, Eitel I (2016) Long-term excess mortality in Takotsubo cardiomyopathy: predictors, causes and clinical consequences. Eur J Heart Fail 18(6):650–656PubMedCrossRef
76.
go back to reference Shams Y (2015) The pathogenesis of reversible T-wave inversions or large upright peaked T-waves: sympathetic T-waves. Int J Cardiol 191:237–243CrossRef Shams Y (2015) The pathogenesis of reversible T-wave inversions or large upright peaked T-waves: sympathetic T-waves. Int J Cardiol 191:237–243CrossRef
77.
go back to reference Shams Y (2015) RESPONSE: the electrocardiographic changes in mid-basal (inverted) Takotsubo syndrome. Ann Noninvasive Electrocardiol 6(20):614–614 Shams Y (2015) RESPONSE: the electrocardiographic changes in mid-basal (inverted) Takotsubo syndrome. Ann Noninvasive Electrocardiol 6(20):614–614
78.
go back to reference Duran-Cambra A, Sutil-Vega M, Fiol M, Núñez-Gil I, Vila M, Sans-Roselló J, Cinca J, Sionis A (2015) Systematic review of the electrocardiographic changes in the takotsubo syndrome. Ann Noninvasive Electrocardiol 20(1):1–6PubMedCrossRef Duran-Cambra A, Sutil-Vega M, Fiol M, Núñez-Gil I, Vila M, Sans-Roselló J, Cinca J, Sionis A (2015) Systematic review of the electrocardiographic changes in the takotsubo syndrome. Ann Noninvasive Electrocardiol 20(1):1–6PubMedCrossRef
79.
go back to reference Abildskov J (1976) Adrenergic effects on the QT interval of the electrocardiogram. Am Heart J 92(2):210–216PubMedCrossRef Abildskov J (1976) Adrenergic effects on the QT interval of the electrocardiogram. Am Heart J 92(2):210–216PubMedCrossRef
80.
go back to reference Magnano AR, Talathoti N, Hallur R, Bloomfield DM, Garan H (2006) Sympathomimetic infusion and cardiac repolarization: the normative effects of epinephrine and isoproterenol in healthy subjects. J Cardiovasc Electrophysiol 17(9):983–989PubMedCrossRef Magnano AR, Talathoti N, Hallur R, Bloomfield DM, Garan H (2006) Sympathomimetic infusion and cardiac repolarization: the normative effects of epinephrine and isoproterenol in healthy subjects. J Cardiovasc Electrophysiol 17(9):983–989PubMedCrossRef
81.
go back to reference Marra MP, Zorzi A, Corbetti F, De Lazzari M, Migliore F, Tona F, Tarantini G, Iliceto S, Corrado D (2013) Apicobasal gradient of left ventricular myocardial edema underlies transient T-wave inversion and QT interval prolongation (Wellens’ ECG pattern) in Tako-Tsubo cardiomyopathy. Heart Rhythm 10(1):70–77CrossRef Marra MP, Zorzi A, Corbetti F, De Lazzari M, Migliore F, Tona F, Tarantini G, Iliceto S, Corrado D (2013) Apicobasal gradient of left ventricular myocardial edema underlies transient T-wave inversion and QT interval prolongation (Wellens’ ECG pattern) in Tako-Tsubo cardiomyopathy. Heart Rhythm 10(1):70–77CrossRef
82.
go back to reference Lee J-H, Uhm J-S, Shin DG, Joung B, Pak H-N, Ko Y-G, Hong G-R, Lee M-H (2016) Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy. Korean J Intern Med 31(3):507–516PubMedPubMedCentralCrossRef Lee J-H, Uhm J-S, Shin DG, Joung B, Pak H-N, Ko Y-G, Hong G-R, Lee M-H (2016) Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy. Korean J Intern Med 31(3):507–516PubMedPubMedCentralCrossRef
83.
go back to reference Santoro F, Brunetti ND, Tarantino N, Romero J, Guastafierro F, Ferraretti A, Di Martino LF, Ieva R, Pellegrino PL, Di Biase M (2017) Dynamic changes of QTc interval and prognostic significance in takotsubo (stress) cardiomyopathy. Clin Cardiol 40:1116–1122PubMedPubMedCentralCrossRef Santoro F, Brunetti ND, Tarantino N, Romero J, Guastafierro F, Ferraretti A, Di Martino LF, Ieva R, Pellegrino PL, Di Biase M (2017) Dynamic changes of QTc interval and prognostic significance in takotsubo (stress) cardiomyopathy. Clin Cardiol 40:1116–1122PubMedPubMedCentralCrossRef
84.
go back to reference Waldenborg M, Soholat M, Kähäri A, Emilsson K, Fröbert O (2011) Multidisciplinary assessment of tako tsubo cardiomyopathy: a prospective case study. BMC Cardiovasc Disord 11(1):14PubMedPubMedCentralCrossRef Waldenborg M, Soholat M, Kähäri A, Emilsson K, Fröbert O (2011) Multidisciplinary assessment of tako tsubo cardiomyopathy: a prospective case study. BMC Cardiovasc Disord 11(1):14PubMedPubMedCentralCrossRef
85.
go back to reference Ortak J, Khattab K, Barantke M, Wiegand UK, Baensch D, Ince H, Nienaber CA, Bonnemeier H (2009) Evolution of cardiac autonomic nervous activity indices in patients presenting with transient left ventricular apical ballooning. Pacing Clin Electrophysiol 32(s1):S21–S25PubMedCrossRef Ortak J, Khattab K, Barantke M, Wiegand UK, Baensch D, Ince H, Nienaber CA, Bonnemeier H (2009) Evolution of cardiac autonomic nervous activity indices in patients presenting with transient left ventricular apical ballooning. Pacing Clin Electrophysiol 32(s1):S21–S25PubMedCrossRef
86.
go back to reference Madias JE (2016) Do we need MIBG in the evaluation of patients with suspected Takotsubo syndrome? Diagnostic, prognostic, and pathophysiologic connotations. Int J Cardiol 203:783–784PubMedCrossRef Madias JE (2016) Do we need MIBG in the evaluation of patients with suspected Takotsubo syndrome? Diagnostic, prognostic, and pathophysiologic connotations. Int J Cardiol 203:783–784PubMedCrossRef
87.
88.
go back to reference Vaccaro A, Despas F, Delmas C, Lairez O, Lambert E, Lambert G, Labrunee M, Guiraud T, Esler M, Galinier M (2014) Direct evidences for sympathetic hyperactivity and baroreflex impairment in Tako Tsubo cardiopathy. PLoS One 9(3):e93278PubMedPubMedCentralCrossRef Vaccaro A, Despas F, Delmas C, Lairez O, Lambert E, Lambert G, Labrunee M, Guiraud T, Esler M, Galinier M (2014) Direct evidences for sympathetic hyperactivity and baroreflex impairment in Tako Tsubo cardiopathy. PLoS One 9(3):e93278PubMedPubMedCentralCrossRef
89.
go back to reference Norcliffe-Kaufmann L, Kaufmann H, Martinez J, Katz SD, Tully L, Reynolds HR (2016) Autonomic findings in Takotsubo cardiomyopathy. Am J Cardiol 117(2):206–213PubMedCrossRef Norcliffe-Kaufmann L, Kaufmann H, Martinez J, Katz SD, Tully L, Reynolds HR (2016) Autonomic findings in Takotsubo cardiomyopathy. Am J Cardiol 117(2):206–213PubMedCrossRef
90.
go back to reference Ali A, Redfors B, Omerovic E (2015) How baroreceptor dysfunction could predispose to the takotsubo syndrome. Int J Cardiol 182:105–106PubMedCrossRef Ali A, Redfors B, Omerovic E (2015) How baroreceptor dysfunction could predispose to the takotsubo syndrome. Int J Cardiol 182:105–106PubMedCrossRef
Metadata
Title
Autonomic nervous system in Takotsubo syndrome
Authors
Sonia Borodzicz
Katarzyna Czarzasta
Grzegorz Opolski
Agnieszka Cudnoch-Jędrzejewska
Publication date
01-01-2019
Publisher
Springer US
Published in
Heart Failure Reviews / Issue 1/2019
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-018-9729-5

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