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Published in: Heart Failure Reviews 3/2015

01-05-2015

Chronic kidney disease and cardiovascular complications

Authors: Luca Di Lullo, Andrew House, Antonio Gorini, Alberto Santoboni, Domenico Russo, Claudio Ronco

Published in: Heart Failure Reviews | Issue 3/2015

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Abstract

Cardiovascular diseases such as coronary artery disease, congestive heart failure, arrhythmias and sudden cardiac death represent main causes of morbidity and mortality in patients with chronic kidney disease (CKD). Pathogenesis includes close linkage between heart and kidneys and involves traditional and non-traditional cardiovascular risk factors. According to a well-established classification of cardiorenal syndrome, cardiovascular involvement in CKD is known as “type-4 cardiorenal syndrome” (chronic renocardiac). The following review makes an overview about epidemiology, pathophysiology, diagnosis and treatment of cardiovascular complications in CKD patients.
Literature
1.
go back to reference Ronco C (2011) The cardiorenal syndrome: basis and common ground for a multidisciplinary patient-oriented therapy. Cardiorenal Med 1:3–4 Ronco C (2011) The cardiorenal syndrome: basis and common ground for a multidisciplinary patient-oriented therapy. Cardiorenal Med 1:3–4
2.
go back to reference Heywood JT, Fonarow GC, Costanzo MR, Mathur VS, Wigneswaran JR, Wynne J, ADHERE Scientific Advisory Committee and Investigators (2007) High prevalence of renal dysfunction and its impact on outcome in 118,465 patients hospitalized with acute decompensated heart failure: a report from the ADHERE database. J Card Fail 13(6):422–430PubMedCrossRef Heywood JT, Fonarow GC, Costanzo MR, Mathur VS, Wigneswaran JR, Wynne J, ADHERE Scientific Advisory Committee and Investigators (2007) High prevalence of renal dysfunction and its impact on outcome in 118,465 patients hospitalized with acute decompensated heart failure: a report from the ADHERE database. J Card Fail 13(6):422–430PubMedCrossRef
3.
go back to reference Foley RN, Parfrey PS, Harnett JD, Kent GM, Murray DC, Barre PE (1995) The prognostic importance of left ventricular geometry in uremic cardiomyopathy. J Am Soc Nephrol 5(12):2024–2031PubMed Foley RN, Parfrey PS, Harnett JD, Kent GM, Murray DC, Barre PE (1995) The prognostic importance of left ventricular geometry in uremic cardiomyopathy. J Am Soc Nephrol 5(12):2024–2031PubMed
4.
go back to reference Harnett JD, Foley RN, Kent GM, Barre PE, Murray D, Parfrey PS (1995) Congestive heart failure in dialysis patients: prevalence, incidence, prognosis and risk factors. Kidney Int 47(3):884–890PubMedCrossRef Harnett JD, Foley RN, Kent GM, Barre PE, Murray D, Parfrey PS (1995) Congestive heart failure in dialysis patients: prevalence, incidence, prognosis and risk factors. Kidney Int 47(3):884–890PubMedCrossRef
5.
6.
go back to reference Garg AX, Clark WF, Haynes RB, House AA (2002) Moderate renal insufficiency and the risk of cardiovascular mortality: results from the NHANES I. Kidney Int 61(4):1486–1494PubMedCrossRef Garg AX, Clark WF, Haynes RB, House AA (2002) Moderate renal insufficiency and the risk of cardiovascular mortality: results from the NHANES I. Kidney Int 61(4):1486–1494PubMedCrossRef
7.
go back to reference US Renal Data System (2012) USRDS 2012 Annual data report: atlas of end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD US Renal Data System (2012) USRDS 2012 Annual data report: atlas of end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
8.
go back to reference Tonelli M, Wiebe N, Culleton B, House A, Rabbat C, Fok M, McAlister F, Garg AX (2006) Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol 17(7):2034–2047PubMedCrossRef Tonelli M, Wiebe N, Culleton B, House A, Rabbat C, Fok M, McAlister F, Garg AX (2006) Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol 17(7):2034–2047PubMedCrossRef
9.
go back to reference Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351(13):1296–1305PubMedCrossRef Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351(13):1296–1305PubMedCrossRef
10.
go back to reference US Renal Data System (2009) USRDS 2009 Annual data report: atlas of end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD US Renal Data System (2009) USRDS 2009 Annual data report: atlas of end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
11.
go back to reference Shastri S, Sarnak MJ (2010) Cardiovascular disease and CKD: core curriculum 2010. Am J Kidney Dis 56(2):399–417PubMedCrossRef Shastri S, Sarnak MJ (2010) Cardiovascular disease and CKD: core curriculum 2010. Am J Kidney Dis 56(2):399–417PubMedCrossRef
12.
go back to reference Stevens LA, Li S, Wang C, Huang C, Becker BN, Bomback AS, Brown WW, Burrows NR, Jurkovitz CT, McFarlane SI, Norris KC, Shlipak M, Whaley-Connell AT, Chen SC, Bakris GL, McCullough PA (2010) Prevalence of CKD and comorbid illness in elderly patients in the united states: results from the kidney early evaluation program (KEEP). Am J Kidney Dis 55(3 Suppl 2):S23–S33PubMedCrossRef Stevens LA, Li S, Wang C, Huang C, Becker BN, Bomback AS, Brown WW, Burrows NR, Jurkovitz CT, McFarlane SI, Norris KC, Shlipak M, Whaley-Connell AT, Chen SC, Bakris GL, McCullough PA (2010) Prevalence of CKD and comorbid illness in elderly patients in the united states: results from the kidney early evaluation program (KEEP). Am J Kidney Dis 55(3 Suppl 2):S23–S33PubMedCrossRef
13.
go back to reference Bansal N, Keane M, Delafontaine P, Dries D, Foster E, Gadegbeku CA, Go AS, Hamm LL, Kusek JW, Ojo AO, Rahman M, Tao K, Wright JT, Xie D, Hsu CY, CRIC Study Investigators (2013) A longitudinal study of left ventricular function and structure from CKD to ESRD: the CRIC study. Clin J Am Soc Nephrol 8(3):355–362PubMedCentralPubMedCrossRef Bansal N, Keane M, Delafontaine P, Dries D, Foster E, Gadegbeku CA, Go AS, Hamm LL, Kusek JW, Ojo AO, Rahman M, Tao K, Wright JT, Xie D, Hsu CY, CRIC Study Investigators (2013) A longitudinal study of left ventricular function and structure from CKD to ESRD: the CRIC study. Clin J Am Soc Nephrol 8(3):355–362PubMedCentralPubMedCrossRef
14.
go back to reference Kottgen A, Russell SD, Loehr LR, Crainiceanu CM, Rosamond WD, Chang PP, Chambless LE, Coresh J (2007) Reduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) study. J Am Soc Nephrol 18(4):1307–1315PubMedCrossRef Kottgen A, Russell SD, Loehr LR, Crainiceanu CM, Rosamond WD, Chang PP, Chambless LE, Coresh J (2007) Reduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) study. J Am Soc Nephrol 18(4):1307–1315PubMedCrossRef
15.
go back to reference Waheed S, Matsushita K, Sang Y, Hoogeveen R, Ballantyne C, Coresh J, Astor BC (2012) Combined association of albuminuria and cystatin C-based estimated GFR with mortality, coronary heart disease, and heart failure outcomes: the atherosclerosis risk in communities (ARIC) study. Am J Kidney Dis 60(2):207–216PubMedCentralPubMedCrossRef Waheed S, Matsushita K, Sang Y, Hoogeveen R, Ballantyne C, Coresh J, Astor BC (2012) Combined association of albuminuria and cystatin C-based estimated GFR with mortality, coronary heart disease, and heart failure outcomes: the atherosclerosis risk in communities (ARIC) study. Am J Kidney Dis 60(2):207–216PubMedCentralPubMedCrossRef
16.
go back to reference Pocock SJ, Ariti CA, McMurray JJ, Maggioni A, Kober L, Squire IB, Swedberg K, Dobson J, Poppe KK, Whalley GA, Doughty RN (2013) Meta-analysis global group in chronic heart failure (MAGGIC). Predicting survival in heart failure: a risk score based on 39,372 patients from 30 studies. Eur Heart J 34(19):1404–1413PubMedCrossRef Pocock SJ, Ariti CA, McMurray JJ, Maggioni A, Kober L, Squire IB, Swedberg K, Dobson J, Poppe KK, Whalley GA, Doughty RN (2013) Meta-analysis global group in chronic heart failure (MAGGIC). Predicting survival in heart failure: a risk score based on 39,372 patients from 30 studies. Eur Heart J 34(19):1404–1413PubMedCrossRef
17.
go back to reference Levin A, Singer J, Thompson CR, Ross H, Lewis M (1996) Prevalent left ventricular hypertrophy in the predialysis population: identifying opportunities for intervention. Am J Kidney Dis 27(3):347–354PubMedCrossRef Levin A, Singer J, Thompson CR, Ross H, Lewis M (1996) Prevalent left ventricular hypertrophy in the predialysis population: identifying opportunities for intervention. Am J Kidney Dis 27(3):347–354PubMedCrossRef
18.
go back to reference Parfrey PS, Harnett JD, Griffiths SM, Taylor R, Hand J, King A, Barre PE (1990) The clinical course of left ventricular hypertrophy in dialysis patients. Nephron 55(2):114–120PubMedCrossRef Parfrey PS, Harnett JD, Griffiths SM, Taylor R, Hand J, King A, Barre PE (1990) The clinical course of left ventricular hypertrophy in dialysis patients. Nephron 55(2):114–120PubMedCrossRef
19.
go back to reference Lezaic V, Tirmenstajn-Jankovic B, Bukvic D, Vujisic B, Perovic M, Novakovic N, Dopsaj V, Maric I, Djukanovic L (2009) Efficacy of hyperphosphatemia control in the progression of chronic renal failure and the prevalence of cardiovascular calcification. Clin Nephrol 71(1):21–29PubMedCrossRef Lezaic V, Tirmenstajn-Jankovic B, Bukvic D, Vujisic B, Perovic M, Novakovic N, Dopsaj V, Maric I, Djukanovic L (2009) Efficacy of hyperphosphatemia control in the progression of chronic renal failure and the prevalence of cardiovascular calcification. Clin Nephrol 71(1):21–29PubMedCrossRef
20.
go back to reference Di Lullo L, Floccari F, Santoboni A, Barbera V, Rivera RF, Granata A, Morrone L, Russo D (2013) Progression of cardiac valve calcification and decline of renal function in CKD patients. J Nephrol 26(4):739–744PubMedCrossRef Di Lullo L, Floccari F, Santoboni A, Barbera V, Rivera RF, Granata A, Morrone L, Russo D (2013) Progression of cardiac valve calcification and decline of renal function in CKD patients. J Nephrol 26(4):739–744PubMedCrossRef
21.
go back to reference Olgaard K, Lewin E, Silver J (2011) Calcimimetics, vitamin D and ADVANCE in the management of CKD–MBD. Nephrol Dial Transplant 26(4):1117–1119 Olgaard K, Lewin E, Silver J (2011) Calcimimetics, vitamin D and ADVANCE in the management of CKD–MBD. Nephrol Dial Transplant 26(4):1117–1119
22.
go back to reference MacRae JM, Pandeya S, Humen DP, Krivitski N, Lindsay RM (2004) Arteriovenous fistula-associated high-output cardiac failure: a review of mechanisms. Am J Kidney Dis 43(5):e17–e22PubMedCrossRef MacRae JM, Pandeya S, Humen DP, Krivitski N, Lindsay RM (2004) Arteriovenous fistula-associated high-output cardiac failure: a review of mechanisms. Am J Kidney Dis 43(5):e17–e22PubMedCrossRef
23.
go back to reference Di Lullo L, Floccari F, Polito P (2011) Right ventricular diastolic function in dialysis patients could be affected by vascular access. Nephron Clin Pract 118:c258–c262CrossRef Di Lullo L, Floccari F, Polito P (2011) Right ventricular diastolic function in dialysis patients could be affected by vascular access. Nephron Clin Pract 118:c258–c262CrossRef
24.
go back to reference Fort J (2005) Chronic renal failure: a cardiovascular risk factor. Kidney Int 68(Suppl 99):S25–S29 Fort J (2005) Chronic renal failure: a cardiovascular risk factor. Kidney Int 68(Suppl 99):S25–S29
25.
go back to reference Schiffrin EL, Lipman ML, Mann JF (2007) Chronic kidney disease: effects on the cardiovascular system. Circulation 116(1):85–97PubMedCrossRef Schiffrin EL, Lipman ML, Mann JF (2007) Chronic kidney disease: effects on the cardiovascular system. Circulation 116(1):85–97PubMedCrossRef
26.
go back to reference Bologa RM, Levine DM, Parker TS et al (1998) Interleukin-6 predicts hypoalbuminemia, hypocholesterolemia, and mortality in hemodialysis patients. Am J Kidney Dis 32(1):107–114PubMedCrossRef Bologa RM, Levine DM, Parker TS et al (1998) Interleukin-6 predicts hypoalbuminemia, hypocholesterolemia, and mortality in hemodialysis patients. Am J Kidney Dis 32(1):107–114PubMedCrossRef
27.
go back to reference Parikh SV, de Lemos JA (2006) Biomarkers in cardiovascular disease: integrating pathophysiology into clinical practice. Am J Med Sci 332(4):186–197PubMedCrossRef Parikh SV, de Lemos JA (2006) Biomarkers in cardiovascular disease: integrating pathophysiology into clinical practice. Am J Med Sci 332(4):186–197PubMedCrossRef
28.
go back to reference Austin WJ, Bhalla V, Hernandez-Arce I et al (2006) Correlation and prognostic utility of B-type natriuretic peptide and its amino-terminal fragment in patients with chronic kidney disease. Am J Clin Pathol 126(4):506–512PubMedCrossRef Austin WJ, Bhalla V, Hernandez-Arce I et al (2006) Correlation and prognostic utility of B-type natriuretic peptide and its amino-terminal fragment in patients with chronic kidney disease. Am J Clin Pathol 126(4):506–512PubMedCrossRef
30.
go back to reference Maisel AS, Katz N, Hillege HL et al (2011) Biomarkers in kidney and heart disease. Nephrol Dial Transplant 26(1):62–74PubMedCrossRef Maisel AS, Katz N, Hillege HL et al (2011) Biomarkers in kidney and heart disease. Nephrol Dial Transplant 26(1):62–74PubMedCrossRef
31.
go back to reference Foley RN, Parfrey PS, Sarnak MJ (1998) Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 32(5 Suppl 3):S112–S119PubMedCrossRef Foley RN, Parfrey PS, Sarnak MJ (1998) Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 32(5 Suppl 3):S112–S119PubMedCrossRef
32.
go back to reference Ichikawa I, Pfeffer JM, Pfeffer MA, Hostetter TH, Brenner BM (1984) Role of angiotensin II in the altered renal function of congestive heart failure. Circ Res 55(5):669–675PubMedCrossRef Ichikawa I, Pfeffer JM, Pfeffer MA, Hostetter TH, Brenner BM (1984) Role of angiotensin II in the altered renal function of congestive heart failure. Circ Res 55(5):669–675PubMedCrossRef
33.
go back to reference Entin-Meer M, Ben-Shoshan J, Maysel-Auslender S, Levy R, Goryainov P, Schwartz I, Barshack I, Avivi C, Sharir R, Keren G (2012) Accelerated renal fibrosis in cardiorenal syndrome is associated with long-term increase in urine neutrophil gelatinase-associated lipocalin levels. Am J Nephrol 36(2):190–200PubMedCrossRef Entin-Meer M, Ben-Shoshan J, Maysel-Auslender S, Levy R, Goryainov P, Schwartz I, Barshack I, Avivi C, Sharir R, Keren G (2012) Accelerated renal fibrosis in cardiorenal syndrome is associated with long-term increase in urine neutrophil gelatinase-associated lipocalin levels. Am J Nephrol 36(2):190–200PubMedCrossRef
34.
go back to reference Lekawanvijit S, Kompa AR, Zhang Y, Wang BH, Kelly DJ, Krum H (2012) Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome. Am J Physiol Heart Circ Physiol 302(9):H1884–H1893PubMedCrossRef Lekawanvijit S, Kompa AR, Zhang Y, Wang BH, Kelly DJ, Krum H (2012) Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome. Am J Physiol Heart Circ Physiol 302(9):H1884–H1893PubMedCrossRef
35.
go back to reference Jovanovich A, Ix JH, Gottdiener J, McFann K, Katz R, Kestenbaum B, de Boer IH, Sarnak M, Shlipak MG, Mukamal KJ, Siscovick D, Chonchol M (2013) Fibroblast growth factor 23, left ventricular mass, and left ventricular hypertrophy in community-dwelling older adults. Atherosclerosis 231(1):114–119PubMedCrossRef Jovanovich A, Ix JH, Gottdiener J, McFann K, Katz R, Kestenbaum B, de Boer IH, Sarnak M, Shlipak MG, Mukamal KJ, Siscovick D, Chonchol M (2013) Fibroblast growth factor 23, left ventricular mass, and left ventricular hypertrophy in community-dwelling older adults. Atherosclerosis 231(1):114–119PubMedCrossRef
36.
go back to reference Shamseddin MK, Parfrey PS, Medscape (2011) Sudden cardiac death in chronic kidney disease: epidemiology and prevention. Nat Rev Nephrol 7(3):145–154 Shamseddin MK, Parfrey PS, Medscape (2011) Sudden cardiac death in chronic kidney disease: epidemiology and prevention. Nat Rev Nephrol 7(3):145–154
37.
go back to reference Kajstura J, Cigola E, Malhotra A et al (1997) Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J Mol Cell Cardiol 29(3):859–870PubMedCrossRef Kajstura J, Cigola E, Malhotra A et al (1997) Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J Mol Cell Cardiol 29(3):859–870PubMedCrossRef
38.
go back to reference Kingma JG Jr, Vincent C, Rouleau JR, Kingma I (2006) Influence of acute renal failure on coronary vasoregulation in dogs. J Am Soc Nephrol 17(5):1316–1324PubMedCrossRef Kingma JG Jr, Vincent C, Rouleau JR, Kingma I (2006) Influence of acute renal failure on coronary vasoregulation in dogs. J Am Soc Nephrol 17(5):1316–1324PubMedCrossRef
39.
go back to reference Lok DJ, Lok SI, Bruggink-André de la Porte PW, Badings E, Lipsic E, van Wijngaarden J, de Boer RA, van Veldhuisen DJ, van der Meer P (2013) Galectin-3 is an independent marker for ventricular remodeling and mortality in patients with chronic heart failure. Clin Res Cardiol 102(2):103–110PubMedCrossRef Lok DJ, Lok SI, Bruggink-André de la Porte PW, Badings E, Lipsic E, van Wijngaarden J, de Boer RA, van Veldhuisen DJ, van der Meer P (2013) Galectin-3 is an independent marker for ventricular remodeling and mortality in patients with chronic heart failure. Clin Res Cardiol 102(2):103–110PubMedCrossRef
41.
go back to reference Winkelmayer WC, Patrick AR, Liu J et al (2011) The increasing prevalence of atrial fibrillation among hemodialysis patients. J Am Soc Nephrol 22(2):349–357PubMedCentralPubMedCrossRef Winkelmayer WC, Patrick AR, Liu J et al (2011) The increasing prevalence of atrial fibrillation among hemodialysis patients. J Am Soc Nephrol 22(2):349–357PubMedCentralPubMedCrossRef
42.
go back to reference Baber U, Howard VJ, Halperin JL et al (2011) Association of chronic kidney disease with atrial fibrillation among adults in the United States: reasons for geographic and racial differences in stroke (REGARDS) study. Circ Arrhythm Electrophysiol 4(1):26–32PubMedCentralPubMedCrossRef Baber U, Howard VJ, Halperin JL et al (2011) Association of chronic kidney disease with atrial fibrillation among adults in the United States: reasons for geographic and racial differences in stroke (REGARDS) study. Circ Arrhythm Electrophysiol 4(1):26–32PubMedCentralPubMedCrossRef
43.
go back to reference Soliman EZ, Prineas RJ, Go AS et al (2010) Chronic kidney disease and prevalent atrial fibrillation: the chronic renal insufficiency cohort (CRIC). Am Heart J 159(6):1102–1107PubMedCentralPubMedCrossRef Soliman EZ, Prineas RJ, Go AS et al (2010) Chronic kidney disease and prevalent atrial fibrillation: the chronic renal insufficiency cohort (CRIC). Am Heart J 159(6):1102–1107PubMedCentralPubMedCrossRef
44.
go back to reference Boerrigter G, Costello-Boerrigter LC, Abraham WT, Sutton MG, Heublein DM, Kruger KM, Hill MR, McCullough PA, Burnett JC Jr (2008) Cardiac resynchronization therapy improves renal function in human heart failure with reduced glomerular filtration rate. J Card Fail 14(7):539–546PubMedCentralPubMedCrossRef Boerrigter G, Costello-Boerrigter LC, Abraham WT, Sutton MG, Heublein DM, Kruger KM, Hill MR, McCullough PA, Burnett JC Jr (2008) Cardiac resynchronization therapy improves renal function in human heart failure with reduced glomerular filtration rate. J Card Fail 14(7):539–546PubMedCentralPubMedCrossRef
45.
46.
go back to reference Wang LW, Fahim MA, Hayen A, Mitchell RL, Lord SW, Baines LA, Craig JC, Webster AC (2011) Cardiac testing for coronary artery disease in potential kidney transplant recipients: a systematic review of test accuracy studies. Am J Kidney Dis 57(3):476–487PubMedCrossRef Wang LW, Fahim MA, Hayen A, Mitchell RL, Lord SW, Baines LA, Craig JC, Webster AC (2011) Cardiac testing for coronary artery disease in potential kidney transplant recipients: a systematic review of test accuracy studies. Am J Kidney Dis 57(3):476–487PubMedCrossRef
47.
go back to reference Chonchol M, Whittle J, Desbien A, Orner MB, Petersen LA, Kressin NR (2008) Chronic kidney disease is associated with angiographic coronary artery disease. Am J Nephrol 28(2):354–360PubMedCrossRef Chonchol M, Whittle J, Desbien A, Orner MB, Petersen LA, Kressin NR (2008) Chronic kidney disease is associated with angiographic coronary artery disease. Am J Nephrol 28(2):354–360PubMedCrossRef
48.
go back to reference Kalantar-Zadeh K, Block G, Humphreys MH, Kopple JD (2003) Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 63(3):793–808PubMedCrossRef Kalantar-Zadeh K, Block G, Humphreys MH, Kopple JD (2003) Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 63(3):793–808PubMedCrossRef
49.
go back to reference Cheung AK, Sarnak MJ, Yan G et al (2000) Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients. Kidney Int 58(1):353–362PubMedCrossRef Cheung AK, Sarnak MJ, Yan G et al (2000) Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients. Kidney Int 58(1):353–362PubMedCrossRef
50.
go back to reference Stenvinkel P, Carrero JJ, Axelsson J, Lindholm B, Heimburger O, Massy Z (2008) Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces it into the uremic puzzle? Clin J Am Soc Nephrol 3(2):505–521PubMedCrossRef Stenvinkel P, Carrero JJ, Axelsson J, Lindholm B, Heimburger O, Massy Z (2008) Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces it into the uremic puzzle? Clin J Am Soc Nephrol 3(2):505–521PubMedCrossRef
51.
go back to reference Moe SM, Chen NX (2008) Mechanisms of vascular calcification in chronic kidney disease. J Am Soc Nephrol 19(2):213–216PubMedCrossRef Moe SM, Chen NX (2008) Mechanisms of vascular calcification in chronic kidney disease. J Am Soc Nephrol 19(2):213–216PubMedCrossRef
52.
go back to reference Shioi A, Taniwaki H, Jono S et al (2001) Monckeberg’s medial sclerosis and inorganic phosphate in uremia. Am J Kidney Dis 38(supplement 1):S7–S9 Shioi A, Taniwaki H, Jono S et al (2001) Monckeberg’s medial sclerosis and inorganic phosphate in uremia. Am J Kidney Dis 38(supplement 1):S7–S9
53.
go back to reference Shanahan CM, Cary NRB, Salisbury JR, Proudfoot D, Weissberg PL, Edmonds ME (1999) Medial localization of mineralization-regulating proteins in association with Monckeberg’s sclerosis: evidence for smooth muscle cell-mediated vascular calcification. Circulation 100(21):2168–2176PubMedCrossRef Shanahan CM, Cary NRB, Salisbury JR, Proudfoot D, Weissberg PL, Edmonds ME (1999) Medial localization of mineralization-regulating proteins in association with Monckeberg’s sclerosis: evidence for smooth muscle cell-mediated vascular calcification. Circulation 100(21):2168–2176PubMedCrossRef
54.
go back to reference Stenvinkel P, Chung SH, Heimbürger O, Lindholm B (2001) Malnutrition, inflammation, and atherosclerosis in peritoneal dialysis patients. Perit Dial Int 21(supplement 3):S157–S162 Stenvinkel P, Chung SH, Heimbürger O, Lindholm B (2001) Malnutrition, inflammation, and atherosclerosis in peritoneal dialysis patients. Perit Dial Int 21(supplement 3):S157–S162
55.
go back to reference London GM, Guerin AP, Marchais SJ, Metivier, Pannier FB, Adda H (2003) Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 18(9):1731–1740 London GM, Guerin AP, Marchais SJ, Metivier, Pannier FB, Adda H (2003) Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 18(9):1731–1740
56.
go back to reference Caliskan Y, Demirturk M, Ozkok A et al (2010) Coronary artery calcification and coronary low velocity in haemodialysis patients. Nephrol Dial Transplant 25(8):2685–2690PubMedCrossRef Caliskan Y, Demirturk M, Ozkok A et al (2010) Coronary artery calcification and coronary low velocity in haemodialysis patients. Nephrol Dial Transplant 25(8):2685–2690PubMedCrossRef
57.
go back to reference Van Der Velde M, Matsushita K, Coresh J et al (2011) Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality: a collaborative meta-analysis of high-risk population cohorts. Kidney Int 79(12):1341–1352 Van Der Velde M, Matsushita K, Coresh J et al (2011) Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality: a collaborative meta-analysis of high-risk population cohorts. Kidney Int 79(12):1341–1352
58.
go back to reference Shirani J, Berezowski K, Roberts WC (1995) Quantitative measurement of normal and excessive (cor adiposum) subepicardial adipose tissue, its clinical significance, and its effect on electrocardiographic QRS voltage. Am J Cardiol 76(5):1–19CrossRef Shirani J, Berezowski K, Roberts WC (1995) Quantitative measurement of normal and excessive (cor adiposum) subepicardial adipose tissue, its clinical significance, and its effect on electrocardiographic QRS voltage. Am J Cardiol 76(5):1–19CrossRef
59.
go back to reference Di Lullo L, Floccari F, Granata A, D’Amelio A, Rivera R, Fiorini F, Malaguti M, Timio M (2011) Ultrasonography: Ariadne’s thread in the diagnosis of cardiorenal syndrome. Cardiorenal Med 2(1):11–17 Di Lullo L, Floccari F, Granata A, D’Amelio A, Rivera R, Fiorini F, Malaguti M, Timio M (2011) Ultrasonography: Ariadne’s thread in the diagnosis of cardiorenal syndrome. Cardiorenal Med 2(1):11–17
60.
go back to reference Di Lullo L, Floccari F, Rivera R, Barbera V, Granata A, Otranto G, Mudoni A, Malaguti M, Santoboni A, Ronco C (2013) Pulmonary hypertension and right heart failure in chronic kidney disease: new challenge for 21st-century cardionephrologists. Cardiorenal Med 3:96–103 Di Lullo L, Floccari F, Rivera R, Barbera V, Granata A, Otranto G, Mudoni A, Malaguti M, Santoboni A, Ronco C (2013) Pulmonary hypertension and right heart failure in chronic kidney disease: new challenge for 21st-century cardionephrologists. Cardiorenal Med 3:96–103
61.
go back to reference Edwards NC, Moody WE, Chue CD, Ferro CJ, Townend JN, Steeds RP (2014) Defining the natural history of uremic cardiomyopathy in chronic kidney disease: the role of cardiovascular magnetic resonance. JACC Cardiovasc Image 7(7):703–714 Edwards NC, Moody WE, Chue CD, Ferro CJ, Townend JN, Steeds RP (2014) Defining the natural history of uremic cardiomyopathy in chronic kidney disease: the role of cardiovascular magnetic resonance. JACC Cardiovasc Image 7(7):703–714
62.
go back to reference Stewart GA, Foster J, Cowan M et al (1999) Echocardiography overestimates left ventricular mass in hemodialysis patients relative to magnetic resonance imaging. Kidney Int 56:2248–2253PubMedCrossRef Stewart GA, Foster J, Cowan M et al (1999) Echocardiography overestimates left ventricular mass in hemodialysis patients relative to magnetic resonance imaging. Kidney Int 56:2248–2253PubMedCrossRef
63.
go back to reference Silberberg JS, Barre PE, Prichard SS, Sniderman AD (1989) Impact of left ventricular hypertrophy on survival in end-stage renal disease. Kidney Int 36:286–290PubMedCrossRef Silberberg JS, Barre PE, Prichard SS, Sniderman AD (1989) Impact of left ventricular hypertrophy on survival in end-stage renal disease. Kidney Int 36:286–290PubMedCrossRef
64.
go back to reference Parfrey PS, Foley RN, Harnett JD, Kent GM, Murray DC, Barre PE (1996) Outcome and risk factors for left ventricular disorders in chronic uraemia. Nephrol Dial Transplant 11:1277–1285PubMedCrossRef Parfrey PS, Foley RN, Harnett JD, Kent GM, Murray DC, Barre PE (1996) Outcome and risk factors for left ventricular disorders in chronic uraemia. Nephrol Dial Transplant 11:1277–1285PubMedCrossRef
65.
go back to reference Ritz E, Bommer J (2009) Cardiovascular problems on hemodialysis: current deficits and potential improvement. Clin J Am Soc Nephrol 4:S71–S78PubMedCrossRef Ritz E, Bommer J (2009) Cardiovascular problems on hemodialysis: current deficits and potential improvement. Clin J Am Soc Nephrol 4:S71–S78PubMedCrossRef
66.
go back to reference Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ (2005) Recommendations for chamber quantification: a report from the American society of echocardiography’s guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the European association of echocardiography, a branch of the European society of cardiology. J Am Soc Echocardiogr 18:1440–1463PubMedCrossRef Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ (2005) Recommendations for chamber quantification: a report from the American society of echocardiography’s guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the European association of echocardiography, a branch of the European society of cardiology. J Am Soc Echocardiogr 18:1440–1463PubMedCrossRef
67.
go back to reference Takeuchi M, Nishikage T, Mor-Avi V, Sugeng L, Weinert L, Nakai H, Salgo IS, Gerard O, Lang RM (2008) Measurement of left ventricular mass by real-time three-dimensional echocardiography: validation against magnetic resonance and comparison with two-dimensional and m-mode measurements. J Am Soc Echocardiogr 21:1001–1005PubMedCrossRef Takeuchi M, Nishikage T, Mor-Avi V, Sugeng L, Weinert L, Nakai H, Salgo IS, Gerard O, Lang RM (2008) Measurement of left ventricular mass by real-time three-dimensional echocardiography: validation against magnetic resonance and comparison with two-dimensional and m-mode measurements. J Am Soc Echocardiogr 21:1001–1005PubMedCrossRef
68.
go back to reference Pewsner D, Juni P, Egger M, Battaglia M, Sundstrom J, Bachmann LM (2007) Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review. BMJ 335:711PubMedCentralPubMedCrossRef Pewsner D, Juni P, Egger M, Battaglia M, Sundstrom J, Bachmann LM (2007) Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review. BMJ 335:711PubMedCentralPubMedCrossRef
69.
go back to reference Kribben A, Witzke O, Hillen U, Barkhausen J, Daul AE, Erbel R (2009) Nephrogenic systemic fibrosis: pathogenesis, diagnosis, and therapy. J Am Coll Cardiol 53:1621–1628PubMedCrossRef Kribben A, Witzke O, Hillen U, Barkhausen J, Daul AE, Erbel R (2009) Nephrogenic systemic fibrosis: pathogenesis, diagnosis, and therapy. J Am Coll Cardiol 53:1621–1628PubMedCrossRef
70.
go back to reference Karohl C, D’Marco Gascón L, Raggi P (2011) Noninvasive imaging for assessment of calcification in chronic kidney disease. Nat Rev Nephrol 7(10):567–577PubMedCrossRef Karohl C, D’Marco Gascón L, Raggi P (2011) Noninvasive imaging for assessment of calcification in chronic kidney disease. Nat Rev Nephrol 7(10):567–577PubMedCrossRef
71.
go back to reference Desbien AM, Chonchol M, Gnahn H, Sander D (2008) Kidney function and progression of carotid intima-media thickness in a community study Am J Kidney Dis 51(4):584–593 Desbien AM, Chonchol M, Gnahn H, Sander D (2008) Kidney function and progression of carotid intima-media thickness in a community study Am J Kidney Dis 51(4):584–593
72.
go back to reference Salk I, Yildiz G, Egilmez H, Atalar MH, Candan F, Cetin A (2014) Carotid artery Doppler ultrasonography in patients with chronic kidney disease. Med Sci Monit 7(20):11–17 Salk I, Yildiz G, Egilmez H, Atalar MH, Candan F, Cetin A (2014) Carotid artery Doppler ultrasonography in patients with chronic kidney disease. Med Sci Monit 7(20):11–17
73.
go back to reference Briet M, Bozec E, Laurent S et al (2006) Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease. Kidney Int 69:350–357PubMedCrossRef Briet M, Bozec E, Laurent S et al (2006) Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease. Kidney Int 69:350–357PubMedCrossRef
74.
go back to reference Chue CD, Edwards NC, Ferro CJ, Townend JN, Steeds RP (2013) Effects of age and chronic kidney disease on regional aortic distensibility: a cardiovascular magnetic resonance study. Int J Cardiol 168:4249–4254PubMedCrossRef Chue CD, Edwards NC, Ferro CJ, Townend JN, Steeds RP (2013) Effects of age and chronic kidney disease on regional aortic distensibility: a cardiovascular magnetic resonance study. Int J Cardiol 168:4249–4254PubMedCrossRef
75.
go back to reference Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S, RENAAL Study Investigators (2001) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345(12):861–869PubMedCrossRef Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S, RENAAL Study Investigators (2001) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345(12):861–869PubMedCrossRef
76.
go back to reference Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Lewis JB, Ritz E, Atkins RC, Rohde R, Raz I, Collaborative Study Group (2001) Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 345(12):851–860PubMedCrossRef Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Lewis JB, Ritz E, Atkins RC, Rohde R, Raz I, Collaborative Study Group (2001) Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 345(12):851–860PubMedCrossRef
77.
go back to reference Berl T, Hunsicker LG, Lewis JB, Pfeffer MA, Porush JG, Rouleau JL, Drury PL, Esmatjes E, Hricik D, Parikh CR, Raz I, Vanhille P, Wiegmann TB, Wolfe BM, Locatelli F, Goldhaber SZ, Lewis EJ, Irbesartan Diabetic Nephropathy Trial. Collaborative Study Group (2003) Cardiovascular outcomes in the irbesartan diabetic nephropathy trial of patients with type 2 diabetes and overt nephropathy. Ann Intern Med 138(7):542–549PubMedCrossRef Berl T, Hunsicker LG, Lewis JB, Pfeffer MA, Porush JG, Rouleau JL, Drury PL, Esmatjes E, Hricik D, Parikh CR, Raz I, Vanhille P, Wiegmann TB, Wolfe BM, Locatelli F, Goldhaber SZ, Lewis EJ, Irbesartan Diabetic Nephropathy Trial. Collaborative Study Group (2003) Cardiovascular outcomes in the irbesartan diabetic nephropathy trial of patients with type 2 diabetes and overt nephropathy. Ann Intern Med 138(7):542–549PubMedCrossRef
78.
go back to reference Zannad F, Kessler M, Lehert P, Grunfeld JP, Thuilliez C, Leizorovicz A, Lechat P (2006) Prevention of cardiovascular events in end-stage renal disease: results of a randomized trial of fosinopril and implications for future studies. Kidney Int 70(7):1318–1324PubMedCrossRef Zannad F, Kessler M, Lehert P, Grunfeld JP, Thuilliez C, Leizorovicz A, Lechat P (2006) Prevention of cardiovascular events in end-stage renal disease: results of a randomized trial of fosinopril and implications for future studies. Kidney Int 70(7):1318–1324PubMedCrossRef
79.
go back to reference Lesogor A, Cohn JN, Latini R, Tognoni G, Krum H, Massie B, Zalewski A, Kandra A, Hua TA, Gimpelewicz C (2013) Interaction between baseline and early worsening of renal function and efficacy of renin–angiotensin–aldosterone system blockade in patients with heart failure: insights from the Val-HeFT study. Eur J Heart Fail 15(11):1236–1244PubMedCrossRef Lesogor A, Cohn JN, Latini R, Tognoni G, Krum H, Massie B, Zalewski A, Kandra A, Hua TA, Gimpelewicz C (2013) Interaction between baseline and early worsening of renal function and efficacy of renin–angiotensin–aldosterone system blockade in patients with heart failure: insights from the Val-HeFT study. Eur J Heart Fail 15(11):1236–1244PubMedCrossRef
80.
go back to reference Cice G, Ferrara L, D’Andrea A, D’Isa S, Di Benedetto A, Cittadini A, Russo PE, Golino P, Calabro R (2003) Carvedilol increases 2-year survival in dialysis patients with dilated cardiomyopathy: a prospective, placebo-controlled trial. J Am Coll Cardiol 41(9):1438–1444PubMedCrossRef Cice G, Ferrara L, D’Andrea A, D’Isa S, Di Benedetto A, Cittadini A, Russo PE, Golino P, Calabro R (2003) Carvedilol increases 2-year survival in dialysis patients with dilated cardiomyopathy: a prospective, placebo-controlled trial. J Am Coll Cardiol 41(9):1438–1444PubMedCrossRef
81.
go back to reference Cohen-Solal A, Kotecha D, van Veldhuisen DJ, Babalis D, Bohm M, Coats AJ, Roughton M, Poole-Wilson P, Tavazzi L, Flather M, SENIORS Investigators (2009) Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial. Eur J Heart Fail 11(9):872–880PubMedCentralPubMedCrossRef Cohen-Solal A, Kotecha D, van Veldhuisen DJ, Babalis D, Bohm M, Coats AJ, Roughton M, Poole-Wilson P, Tavazzi L, Flather M, SENIORS Investigators (2009) Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial. Eur J Heart Fail 11(9):872–880PubMedCentralPubMedCrossRef
82.
go back to reference The CONSENSUS Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure: results of the cooperative north scandinavian enalapril survival study (CONSENSUS). N Engl J Med 316(23):1429–1435 The CONSENSUS Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure: results of the cooperative north scandinavian enalapril survival study (CONSENSUS). N Engl J Med 316(23):1429–1435
83.
go back to reference Suki WN, Zabaneh R, Cangiano JL, Reed J, Fischer D, Garrett L, Ling BN, Chasan-Taber S, Dillon MA, Blair AT, Burke SK (2007) Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients. Kidney Int 72(9):1130–1137 Suki WN, Zabaneh R, Cangiano JL, Reed J, Fischer D, Garrett L, Ling BN, Chasan-Taber S, Dillon MA, Blair AT, Burke SK (2007) Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients. Kidney Int 72(9):1130–1137
84.
go back to reference EVOLVE Trial Investigators, Chertow GM, Block GA, Correa-Rotter R, Drueke TB, Floege J, Goodman WG, Herzog CA, Kubo Y, London GM, Mahaffey KW, Mix TC, Moe SM, Trotman ML, Wheeler DC, Parfrey PS (2012) Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. N Engl J Med 367(26):2482–2494 EVOLVE Trial Investigators, Chertow GM, Block GA, Correa-Rotter R, Drueke TB, Floege J, Goodman WG, Herzog CA, Kubo Y, London GM, Mahaffey KW, Mix TC, Moe SM, Trotman ML, Wheeler DC, Parfrey PS (2012) Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. N Engl J Med 367(26):2482–2494
85.
go back to reference Shepherd J, Kastelein JJ, Bittner V, Deedwania P, Breazna A, Dobson S, Wilson DJ, Zuckerman A, Wenger NK, TNT (Treating to New Targets) Investigators (2008) Intensive lipid lowering with atorvastatin in patients with coronary heart disease and chronic kidney disease: the TNT (treating to new targets) study. J Am Coll Cardiol 51(15):1448–1454PubMedCrossRef Shepherd J, Kastelein JJ, Bittner V, Deedwania P, Breazna A, Dobson S, Wilson DJ, Zuckerman A, Wenger NK, TNT (Treating to New Targets) Investigators (2008) Intensive lipid lowering with atorvastatin in patients with coronary heart disease and chronic kidney disease: the TNT (treating to new targets) study. J Am Coll Cardiol 51(15):1448–1454PubMedCrossRef
86.
go back to reference Wanner C, Krane V, Marz W et al (2005) Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N Engl J Med 353(3):238–248PubMedCrossRef Wanner C, Krane V, Marz W et al (2005) Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N Engl J Med 353(3):238–248PubMedCrossRef
87.
go back to reference Fellstrom BC, Jardine AG, Schmieder RE et al (2009) Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N Engl J Med 360(14):1395–1407PubMedCrossRef Fellstrom BC, Jardine AG, Schmieder RE et al (2009) Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N Engl J Med 360(14):1395–1407PubMedCrossRef
88.
go back to reference Suzuki H, Watanabe Y, Kumagai H, Shuto H (2013) Comparative efficacy and adverse effects of the addition of ezetimibe to statin versus statin titration in chronic kidney disease patients. Ther Adv Cardiovasc Dis 7(6):306–315PubMedCrossRef Suzuki H, Watanabe Y, Kumagai H, Shuto H (2013) Comparative efficacy and adverse effects of the addition of ezetimibe to statin versus statin titration in chronic kidney disease patients. Ther Adv Cardiovasc Dis 7(6):306–315PubMedCrossRef
89.
go back to reference FHN Trial Group, Chertow GM, Levin NW, Beck GJ, Depner TA, Eggers PW, Gassman JJ, Gorodetskaya I, Greene T, James S, Larive B, Lindsay RM, Mehta RL, Miller B, Ornt DB, Rajagopalan S, Rastogi A, Rocco MV, Schiller B, Sergeyeva O, Schulman G, Ting GO, Unruh ML, Star RA, Kliger AS (2010) In-center hemodialysis six times per week versus three times per week. N Engl J Med 363(24):2287–2300 FHN Trial Group, Chertow GM, Levin NW, Beck GJ, Depner TA, Eggers PW, Gassman JJ, Gorodetskaya I, Greene T, James S, Larive B, Lindsay RM, Mehta RL, Miller B, Ornt DB, Rajagopalan S, Rastogi A, Rocco MV, Schiller B, Sergeyeva O, Schulman G, Ting GO, Unruh ML, Star RA, Kliger AS (2010) In-center hemodialysis six times per week versus three times per week. N Engl J Med 363(24):2287–2300
90.
go back to reference Matsumoto M, Io H, Furukawa M, Okumura K, Masuda A, Seto T, Takagi M, Sato M, Nagahama L, Omote K, Hisada A, Horikoshi S, Tomino Y (2012) Risk factors associated with increased left ventricular mass index in chronic kidney disease patients evaluated using echocardiography. J Nephrol 25(5):794–801PubMedCrossRef Matsumoto M, Io H, Furukawa M, Okumura K, Masuda A, Seto T, Takagi M, Sato M, Nagahama L, Omote K, Hisada A, Horikoshi S, Tomino Y (2012) Risk factors associated with increased left ventricular mass index in chronic kidney disease patients evaluated using echocardiography. J Nephrol 25(5):794–801PubMedCrossRef
91.
go back to reference Levin A, Djurdjev O, Thompson C, Barrett B, Ethier J, Carlisle E, Barre P, Magner P, Muirhead N, Tobe S, Tam P, Wadgymar JA, Kappel J, Holland D, Pichette V, Shoker A, Soltys G, Verrelli M, Singer J (2005) Canadian randomized trial of hemoglobin maintenance to prevent or delay left ventricular mass growth in patients with CKD. Am J Kidney Dis 46(5):799–811PubMedCrossRef Levin A, Djurdjev O, Thompson C, Barrett B, Ethier J, Carlisle E, Barre P, Magner P, Muirhead N, Tobe S, Tam P, Wadgymar JA, Kappel J, Holland D, Pichette V, Shoker A, Soltys G, Verrelli M, Singer J (2005) Canadian randomized trial of hemoglobin maintenance to prevent or delay left ventricular mass growth in patients with CKD. Am J Kidney Dis 46(5):799–811PubMedCrossRef
92.
go back to reference Parfrey PS, Lauve M, Latremouille-Viau D, Lefebvre P (2009) Erythropoietin therapy and left ventricular mass index in CKD and ESRD patients: a meta-analysis. Clin J Am Soc Nephrol 4(4):755–762PubMedCentralPubMedCrossRef Parfrey PS, Lauve M, Latremouille-Viau D, Lefebvre P (2009) Erythropoietin therapy and left ventricular mass index in CKD and ESRD patients: a meta-analysis. Clin J Am Soc Nephrol 4(4):755–762PubMedCentralPubMedCrossRef
93.
go back to reference Di Lullo L, Floccari F, Granata A, Malaguti M (2012) Low-dose treatment with erythropoiesis-stimulating agents and cardiovascular Geometry in chronic kidney disease: is darbepoetin-α more effective than expected? Cardiorenal Med 2:18–25 Di Lullo L, Floccari F, Granata A, Malaguti M (2012) Low-dose treatment with erythropoiesis-stimulating agents and cardiovascular Geometry in chronic kidney disease: is darbepoetin-α more effective than expected? Cardiorenal Med 2:18–25
94.
go back to reference Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, Reddan D, CHOIR Investigators (2006) Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 355(20):2085–2098PubMedCrossRef Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, Reddan D, CHOIR Investigators (2006) Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 355(20):2085–2098PubMedCrossRef
95.
go back to reference Drueke TB, Locatelli F, Clyne N, Eckardt KU, Macdougall IC, Tsakiris D, Burger HU, Scherhag A, CREATE Investigators (2006) Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 355(20):2071–2084PubMedCrossRef Drueke TB, Locatelli F, Clyne N, Eckardt KU, Macdougall IC, Tsakiris D, Burger HU, Scherhag A, CREATE Investigators (2006) Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 355(20):2071–2084PubMedCrossRef
96.
go back to reference Besarab A, Goodkin DA, Nissenson AR, Normal Hematocrit Cardiac Trial Authors (2008) The normal hematocrit study: follow-up. N Engl J Med 358(4):433–434PubMedCrossRef Besarab A, Goodkin DA, Nissenson AR, Normal Hematocrit Cardiac Trial Authors (2008) The normal hematocrit study: follow-up. N Engl J Med 358(4):433–434PubMedCrossRef
97.
go back to reference Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, Feyzi JM, Ivanovich P, Kewalramani R, Levey AS, Lewis EF, McGill JB, McMurray JJ, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto R, TREAT Investigators (2009) A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 361(21):2019–2032PubMedCrossRef Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, Feyzi JM, Ivanovich P, Kewalramani R, Levey AS, Lewis EF, McGill JB, McMurray JJ, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto R, TREAT Investigators (2009) A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 361(21):2019–2032PubMedCrossRef
98.
go back to reference Kidney Disease Outcomes Quality Initiatives (K/DOQI) (2004) Clinical practice guidelines on hypertension and hypertensive agents in chronic kidney disease. Am J Kidney Dis 43(5 Suppl 1):S1–S290 Kidney Disease Outcomes Quality Initiatives (K/DOQI) (2004) Clinical practice guidelines on hypertension and hypertensive agents in chronic kidney disease. Am J Kidney Dis 43(5 Suppl 1):S1–S290
99.
go back to reference Kidney Disease Outcomes Quality Initiatives (K/DOQI) (2007) Clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease. Am J Kidney Dis 49(2 Suppl 2):S12–S154 Kidney Disease Outcomes Quality Initiatives (K/DOQI) (2007) Clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease. Am J Kidney Dis 49(2 Suppl 2):S12–S154
100.
go back to reference Kidney Disease Outcomes Quality Initiatives (K/DOQI) (2009) Clinical practice guideline for the diagnosis, evaluation, prevention and treatment of chronic kidney disease–mineral and bone disorder (CKD–MBD). Treatment of CKD–MBD targeted at lowering high serum phosphorus and maintaining serum calcium. Kidney Int 76(Suppl 113):S50–S69 Kidney Disease Outcomes Quality Initiatives (K/DOQI) (2009) Clinical practice guideline for the diagnosis, evaluation, prevention and treatment of chronic kidney disease–mineral and bone disorder (CKD–MBD). Treatment of CKD–MBD targeted at lowering high serum phosphorus and maintaining serum calcium. Kidney Int 76(Suppl 113):S50–S69
101.
go back to reference Di Lullo L, Santoboni A, Floccari F, Rivera R, De Pascalis A, Gorini A, Barbera V, Ronco C (2014) Chronic kidney disease and sudden death. G Ital Nefrol 31(3) Di Lullo L, Santoboni A, Floccari F, Rivera R, De Pascalis A, Gorini A, Barbera V, Ronco C (2014) Chronic kidney disease and sudden death. G Ital Nefrol 31(3)
102.
go back to reference Herzog CA, Mangrum JM, Passman R (2008) Sudden cardiac death and dialysis patients. Semin Dial 21(4):300–307PubMedCrossRef Herzog CA, Mangrum JM, Passman R (2008) Sudden cardiac death and dialysis patients. Semin Dial 21(4):300–307PubMedCrossRef
Metadata
Title
Chronic kidney disease and cardiovascular complications
Authors
Luca Di Lullo
Andrew House
Antonio Gorini
Alberto Santoboni
Domenico Russo
Claudio Ronco
Publication date
01-05-2015
Publisher
Springer US
Published in
Heart Failure Reviews / Issue 3/2015
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-014-9460-9

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