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European Journal of Epidemiology
Published in: European Journal of Epidemiology 9/2012

01-09-2012 | STUDY UPDATE

The Generation R Study: design and cohort update 2012

Authors: Vincent W. V. Jaddoe, Cornelia M. van Duijn, Oscar H. Franco, Albert J. van der Heijden, Marinus H. van IIzendoorn, Johan C. de Jongste, Aad van der Lugt, Johan P. Mackenbach, Henriëtte A. Moll, Hein Raat, Fernando Rivadeneira, Eric A. P. Steegers, Henning Tiemeier, Andre G. Uitterlinden, Frank C. Verhulst, Albert Hofman

Published in: European Journal of Epidemiology | Issue 9/2012

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Abstract

The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in childhood; and (6) health and healthcare for children and their parents. Main exposures of interest include environmental, endocrine, genetic and epigenetic, lifestyle related, nutritional and socio-demographic determinants. In total, n = 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61 %, and general follow-up rates until the age of 6 years exceed 80 %. Data collection in mothers, fathers and children include questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome and epigenome wide association screen is available in the participating children. From the age of 5 years, regular detailed hands-on assessments are performed in a dedicated research center including advanced imaging facilities such as Magnetic Resonance Imaging. Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
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Metadata
Title
The Generation R Study: design and cohort update 2012
Authors
Vincent W. V. Jaddoe
Cornelia M. van Duijn
Oscar H. Franco
Albert J. van der Heijden
Marinus H. van IIzendoorn
Johan C. de Jongste
Aad van der Lugt
Johan P. Mackenbach
Henriëtte A. Moll
Hein Raat
Fernando Rivadeneira
Eric A. P. Steegers
Henning Tiemeier
Andre G. Uitterlinden
Frank C. Verhulst
Albert Hofman
Publication date
01-09-2012
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 9/2012
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-012-9735-1

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