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European Journal of Epidemiology
Published in: European Journal of Epidemiology 1/2010

01-01-2010 | PEDIATRIC EPIDEMIOLOGY

Nitric oxide and clustering of metabolic syndrome components in pediatrics

Authors: Asghar Ghasemi, Saleh Zahediasl, Fereidoun Azizi

Published in: European Journal of Epidemiology | Issue 1/2010

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Abstract

This study was performed to determine the risk factor pattern of the metabolic syndrome (MetS) in association with serum nitric oxide metabolites (NO x ) in children and adolescents. The study included 851 children and adolescents, aged 4–19 years. The MetS was defined according to modified Adult treatment Panel III criteria. Cluster analysis was performed using principle components analysis with varimax orthogonal rotation to examine the risk factor pattern of the MetS. The prevalence of MetS was 10.8 and 10.0% in males and females, respectively. Age-and sex-adjusted odds ratio of having MetS was significantly higher in the upper quartile of NO x compared to the lower quartile (2.2, 95% CI: 1.1–4.7, p = 0.029). In the whole population, three factors were identified including blood pressure/obesity, lipid/obesity, and glucose/NO x . Stratifying for sex, again three factors were retained; however, in males NO x was loaded in two factors. In conclusion, serum NO x was associated and loaded with other MetS components in cluster analysis of metabolic risk factors.
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Metadata
Title
Nitric oxide and clustering of metabolic syndrome components in pediatrics
Authors
Asghar Ghasemi
Saleh Zahediasl
Fereidoun Azizi
Publication date
01-01-2010
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 1/2010
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-009-9382-3

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