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European Journal of Epidemiology
Published in: European Journal of Epidemiology 8/2010

Open Access 01-08-2010 | NEURO-EPIDEMIOLOGY

Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study

Authors: M. Schuur, P. Henneman, J. C. van Swieten, M. C. Zillikens, I. de Koning, A. C. J. W. Janssens, J. C. M. Witteman, Y. S. Aulchenko, R. R. Frants, B. A. Oostra, K. Willems van Dijk, C. M. van Duijn

Published in: European Journal of Epidemiology | Issue 8/2010

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Abstract

While type 2 diabetes is well-known to be associated with poorer cognitive performance, few studies have reported on the association of metabolic syndrome (MetS) and contributing factors, such as insulin-resistance (HOMA-IR), low adiponectin-, and high C-reactive protein (CRP)- levels. We studied whether these factors are related to cognitive function and which of the MetS components are independently associated. The study was embedded in an ongoing family-based cohort study in a Dutch population. All participants underwent physical examinations, biomedical measurements, and neuropsychological testing. Linear regression models were used to determine the association between MetS, HOMA-IR, adiponectin levels, CRP, and cognitive test scores. Cross-sectional analyses were performed in 1,898 subjects (mean age 48 years, 43% men). People with MetS had significantly higher HOMA-IR scores, lower adiponectin levels, and higher CRP levels. MetS and high HOMA-IR were associated with poorer executive function in women (P = 0.03 and P = 0.009). MetS and HOMA-IR are associated with poorer executive function in women.
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Metadata
Title
Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study
Authors
M. Schuur
P. Henneman
J. C. van Swieten
M. C. Zillikens
I. de Koning
A. C. J. W. Janssens
J. C. M. Witteman
Y. S. Aulchenko
R. R. Frants
B. A. Oostra
K. Willems van Dijk
C. M. van Duijn
Publication date
01-08-2010
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 8/2010
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-010-9476-y

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