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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 4/2018

01-12-2018 | NON-THEMATIC REVIEW

Perspectives on the role of brain cellular players in cancer-associated brain metastasis: translational approach to understand molecular mechanism of tumor progression

Authors: Masoom Raza, Peeyush Prasad, Pragya Gupta, Naveen Kumar, Taruna Sharma, Mandeep Rana, Aaron Goldman, Seema Sehrawat

Published in: Cancer and Metastasis Reviews | Issue 4/2018

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Abstract

Brain metastasis is one of the leading causes of death among cancer patients. Cancer cells migrate to various sites and harbor different niche in the body which help cancer cells in their survival. The brain is one of the safest place where cancer cells are protected from immune cells. Breast, lung, and melanoma cancer cells have high propensity to migrate towards the brain. To enter the brain, cancer cells have to cross the blood brain barrier. Survival and finding new niche in the brain are directed by several mechanisms in which different cellular players take part such as astrocytes, microglia, Schwann cells, satellite cells, oligodendrocytes, and ependymal cells. Usually, cancer cells highjack the machinery of brain cellular players to survive in the brain environment. It has been shown that co-culture of M2 macrophage with cancer cells leads to increased proliferation and survival of cancer cells. One of the challenges of understanding brain metastasis is appropriate model system to understand dynamic interaction of cancer cells and brain cellular players. To meet this challenge, microfluidic-based devices are employed which can mimic the dynamic conditions as well as can be used for culturing human cells for personalized therapy. In this review, we have systematically reviewed the current status of the role of cellular players in brain metastasis along with explaining how translational approach of microfluidics can be employed for finding new drug target as well as biomarker for brain metastasis. Finally, we have also commented on the mechanism of action of drugs against brain metastasis.
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Metadata
Title
Perspectives on the role of brain cellular players in cancer-associated brain metastasis: translational approach to understand molecular mechanism of tumor progression
Authors
Masoom Raza
Peeyush Prasad
Pragya Gupta
Naveen Kumar
Taruna Sharma
Mandeep Rana
Aaron Goldman
Seema Sehrawat
Publication date
01-12-2018
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 4/2018
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-018-9766-5

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