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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 1/2018

01-03-2018

Long non-coding RNAs in metastasis

Authors: Qihong Huang, Jinchun Yan, Reuven Agami

Published in: Cancer and Metastasis Reviews | Issue 1/2018

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Abstract

Long non-coding RNA (lncRNA) genes have recently been discovered as key regulators of developmental, physiological, and pathological processes in humans. Recent studies indicate that lncRNAs regulate every step of gene expression, and their aberrant expression can be found in the majority of cancer types. Particularly, lncRNAs were found to function in tumor development and metastasis, which is the major cause of cancer-related death. Thus, exploring key roles of lncRNAs in metastasis is predicted to enhance our knowledge of metastasis, and uncover novel therapeutic targets and biomarkers of this process. In this review, we discuss the molecular mechanisms of lncRNAs in gene expression regulation and their function in metastasis.
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Metadata
Title
Long non-coding RNAs in metastasis
Authors
Qihong Huang
Jinchun Yan
Reuven Agami
Publication date
01-03-2018
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 1/2018
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-017-9713-x

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