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Published in:

01-03-2017

Metastatic melanoma moves on: translational science in the era of personalized medicine

Authors: Mitchell P. Levesque, Phil F. Cheng, Marieke I.G. Raaijmakers, Annalisa Saltari, Reinhard Dummer

Published in: Cancer and Metastasis Reviews | Issue 1/2017

Abstract

Progress in understanding and treating metastatic melanoma is the result of decades of basic and translational research as well as the development of better in vitro tools for modeling the disease. Here, we review the latest therapeutic options for metastatic melanoma and the known genetic and non-genetic mechanisms of resistance to these therapies, as well as the in vitro toolbox that has provided the greatest insights into melanoma progression. These include next-generation sequencing technologies and more complex 2D and 3D cell culture models to functionally test the data generated by genomics approaches. The combination of hypothesis generating and hypothesis testing paradigms reviewed here will be the foundation for the next phase of metastatic melanoma therapies in the coming years.

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Title: Metastatic melanoma moves on: translational science in the era of personalized medicine
Authors: Mitchell P. Levesque
Phil F. Cheng
Marieke I.G. Raaijmakers
Annalisa Saltari
Reinhard Dummer
Publication date: 01-03-2017
Publisher: Springer US
Published in: Cancer and Metastasis Reviews / Issue 1/2017
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-017-9658-0

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