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01-03-2017 | Clinical

Anesthetic technique and cancer recurrence in oncologic surgery: unraveling the puzzle

Author: Ryungsa. Kim

Published in: Cancer and Metastasis Reviews | Issue 1/2017

Abstract

Surgery/anesthetic technique-stimulated immunosuppression in the perioperative period might cause an increase in cancer-related mortality. Whether anesthetic technique can affect the outcomes of cancer patients remains inconclusive. This review discusses data from the available literature on anesthetic techniques applied in oncologic surgery, the long-term outcomes of anesthetic technique, and their relation to survival and cancer recurrence. Searches of the PubMed database up to June 30, 2016, were conducted to identify publications with the terms “anesthetic technique and cancer recurrence,” “regional anesthesia and cancer recurrence,” “local anesthesia and cancer recurrence,” “anesthetic technique and immunosuppression,” and “anesthetic technique and oncologic surgery.” Surgery/anesthesia-stimulated activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS) provides immunosuppression through several soluble factors. Volatile anesthetics and opioids suppress cell-mediated immunity (CMI) and promote the proliferation of cancer cells and angiogenesis, whereas propofol does not suppress CMI and inhibits tumor angiogenesis. Regional anesthesia (RA) protects CMI and diminishes the surgical neuroendocrine stress response by blocking afferent neural transmission that stimulates the HPA axis and SNS, decreasing the requirement for opioids and volatile anesthetics and thereby decreasing cancer recurrence. Preclinical and retrospective studies highlight a potential benefit of anesthetic technique in reducing cancer-related mortality and recurrence by attenuating immunosuppression following surgical treatment in patients with specific types of cancer. Several well-planned, prospective, randomized controlled trials (RCTs) are underway that may provide more conclusive and definitive results regarding the benefits of anesthetic technique on survival in oncologic surgery.

Heaney, A., & Buggy, D. J. (2012). Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis? British Journal of Anaesthesiology, 109(Suppl 1), i17–i28. doi:10.1093/bja/aes421.CrossRef

Talmadge, J. E., & Fidler, I. J. (2010). AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Research, 70(14), 5649–5669. doi:10.1158/0008-5472.CAN-10-1040.PubMedPubMedCentralCrossRef

Alsina, E., Matute, E., Ruiz-Huerta, A. D., & Gilsanz, F. (2014). The effects of sevoflurane or remifentanil on the stress response to surgical stimulus. Current Pharmaceutical Design, 20(34), 5449–5468.PubMedCrossRef

O’Dwyer, M. J., Owen, H. C., & Torrance, H. D. (2015). The perioperative immune response. Current Opinion in Critical Care, 21(4), 336–342. doi:10.1097/MCC.0000000000000213.PubMedCrossRef

Bar-Yosef, S., Melamed, R., Page, G. G., Shakhar, G., Shakhar, K., & Ben-Eliyahu, S. (2001). Attenuation of the tumor-promoting effect of surgery by spinal blockade in rats. Anesthesiology, 94(6), 1066–1073.PubMedCrossRef

Melamed, R., Bar-Yosef, S., Shakhar, G., Shakhar, K., & Ben-Eliyahu, S. (2003). Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures. Anesthesiaa & Analgesia, 97(5), 1331–1339.CrossRef

Snyder, G. L., & Greenberg, S. (2010). Effect of anaesthetic technique and other perioperative factors on cancer recurrence. British Journal Anaesthesiology, 105(2), 106–115. doi:10.1093/bja/aeq164.CrossRef

Green, J. S., & Tsui, B. C. (2013). Impact of anesthesia for cancer surgery: continuing professional development. Canadian Journal Anaesthesia, 60(12), 1248–1269. doi:10.1007/s12630-013-0037-1.CrossRef

Ash, S. A., & Buggy, D. J. (2013). Does regional anaesthesia and analgesia or opioid analgesia influence recurrence after primary cancer surgery? An update of available evidence. Best Practice & Research Clinical Anaesthesiology, 27(4), 441–456. doi:10.1016/j.bpa.2013.10.005.CrossRef

10.

Cassinello, F., Prieto, I., del Olmo, M., Rivas, S., & Strichartz, G. R. (2015). Cancer surgery: how may anesthesia influence outcome? Journal of Clinical Anesthesia, 27(3), 262–272. doi:10.1016/j.jclinane.2015.02.007.PubMedCrossRef

11.

Votta-Velis, E. G., Piegeler, T., Minshall, R. D., Aguirre, J., Beck-Schimmer, B., Schwartz, D. E., et al. (2013). Regional anaesthesia and cancer metastases: the implication of local anaesthetics. Acta Anaesthesiologica Scandinavica, 57(10), 1211–1229. doi:10.1111/aas.12210.PubMedCrossRef

12.

Byrne, K., Levins, K. J., & Buggy, D. J. (2016). Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis? Canadian Journal Anaesthesia, 63(2), 184–192.CrossRef

13.

Meserve, J. R., Kaye, A. D., Prabhakar, A., & Urman, R. D. (2014). The role of analgesics in cancer propagation. Best Practice & Research Clinical Anaesthesiology, 28(2), 139–151. doi:10.1016/j.bpa.2014.04.004.CrossRef

14.

Bajwa, S. J., Anand, S., & Kaur, G. (2015). Anesthesia and cancer recurrences: the current knowledge and evidence. Journal Cancer Research and Therapeutics, 11(3), 528–534. doi:10.4103/0973-1482.157321.CrossRef

15.

Xuan, W., Hankin, J., Zhao, H., Yao, S., & Ma, D. (2015). The potential benefits of the use of regional anesthesia in cancer patients. International Journal of Cancer, 137(12), 2774–2784. doi:10.1002/ijc.29306.PubMedCrossRef

16.

Kim, R., Emi, M., Tanabe, K., & Arihiro, K. (2006). Tumor-driven evolution of immunosuppressive networks during malignant progression. Cancer Research, 66(11), 5527–5536.PubMedCrossRef

17.

Kavanagh, T., & Buggy, D. J. (2012). Can anaesthetic technique effect postoperative outcome? Current Opinion in Anaesthesiology, 25(2), 185–198. doi:10.1097/ACO.0b013e32834f6c4c.PubMedCrossRef

18.

Kurosawa, S., & Kato, M. (2008). Anesthetics, immune cells, and immune responses. Journal of Anesthesia, 22(3), 263–277. doi:10.1007/s00540-008-0626-2.PubMedCrossRef

19.

Lee, B. M., & Cata, J. P. (2015). Impact of anesthesia on cancer recurrence. Revista Española de Anestesiología y Reanimación, 62(10), 570–575. doi:10.1016/j.redar.2015.04.003.PubMedCrossRef

20.

Greenfeld, K., Avraham, R., Benish, M., Goldfarb, Y., Rosenne, E., Shapira, Y., et al. (2007). Immune suppression while awaiting surgery and following it: dissociations between plasma cytokine levels, their induced production, and NK cell cytotoxicity. Brain, Behavior, and Immunity, 21(4), 503–513.PubMedCrossRef

21.

Sood, A. K., Bhatty, R., Kamat, A. A., Landen, C. N., Han, L., Thaker, P. H., et al. (2006). Stress hormone-mediated invasion of ovarian cancer cells. Clinical Cancer Research, 12(2), 369–375.PubMedPubMedCentralCrossRef

22.

Wong, H. P., Ho, J. W., Koo, M. W., Yu, L., Wu, W. K., Lam, E. K., et al. (2011). Effects of adrenaline in human colon adenocarcinoma HT-29 cells. Life Sciences, 88(25–26), 1108–1112. doi:10.1016/j.lfs.2011.04.007.PubMedCrossRef

23.

Bernabé, D. G., Tamae, A. C., Biasoli, É. R., & Oliveira, S. H. (2011). Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cells. Brain, Behavior, and Immunity, 25(3), 574–583. doi:10.1016/j.bbi.2010.12.012.PubMedCrossRef

24.

Yang, E. V., Kim, S. J., Donovan, E. L., Chen, M., Gross, A. C., Webster Marketon, J. I., et al. (2009). Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Brain, Behavior, and Immunity, 23(2), 267–275. doi:10.1016/j.bbi.2008.10.005.PubMedCrossRef

25.

Calcagni, E., & Elenkov, I. (2006). Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Annals of the New York Academy of Sciences, 1069, 62–76.PubMedCrossRef

26.

Marik, P. E., & Flemmer, M. (2012). Immunonutrition in the surgical patient. See comment in PubMed Commons below Minerva Anestesiologica, 78(3), 336–342.PubMed

27.

Sica, A., Schioppa, T., Mantovani, A., & Allavena, P. (2006). Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eurlopian Journal of Cancer, 42(6), 717–727.CrossRef

28.

Obermajer, N., Wong, J. L., Edwards, R. P., Odunsi, K., Moysich, K., & Kalinski, P. (2012). PGE₂-driven induction and maintenance of cancer-associated myeloid-derived suppressor cells. Immunological Investigations, 41(6–7), 635–657. doi:10.3109/08820139.2012.695417.PubMedCrossRef

29.

Mao, Y., Sarhan, D., Steven, A., Seliger, B., Kiessling, R., & Lundqvist, A. (2014). Inhibition of tumor-derived prostaglandin-E₂ blocks the induction of myeloid-derived suppressor cells and recovers natural killer cell activity. Clinical Cancer Research, 20(15), 4096–4106. doi:10.1158/1078-0432.CCR-14-0635.PubMedCrossRef

30.

Kitamura, T., Qian, B. Z., & Pollard, J. W. (2015). Immune cell promotion of metastasis. Nature Reviews Immunology, 15(2), 73–86. doi:10.1038/nri3789.PubMedPubMedCentralCrossRef

31.

John, A., & Tuszynski, G. (2001). The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathology & Oncology Research, 7(1), 14–23.CrossRef

32.

Zappalà, G., McDonald, P. G., & Cole, S. W. (2013). Tumor dormancy and the neuroendocrine system: an undisclosed connection? Cancer and Metastasis Reviews, 32(1–2), 189–200. doi:10.1007/s10555-012-9400-x.PubMedCrossRef

33.

Folkman, J. (2002). Role of angiogenesis in tumor growth and metastasis. Seminars in Oncology, 29(6 Suppl 16), 15–18.PubMedCrossRef

34.

Exadaktylos, A. K., Buggy, D. J., Moriarty, D. C., Mascha, E., & Sessler, D. I. (2006). Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology, 105(4), 660–664.PubMedPubMedCentralCrossRef

35.

Koonce, S. L., Mclaughlin, S. A., Eck, D. L., Porter, S., Bagaria, S., Clendenen, S. R., et al. (2014). Breast cancer recurrence in patients receiving epidural and paravertebral anesthesia: a retrospective, case-control study. Middle East Journal of Anesthesiology, 22(6), 567–571.PubMed

36.

Starnes-Ott, K., Goravanchi, F., & Meininger, J. C. (2015). Anesthetic choices and breast cancer recurrence: a retrospective pilot study of patient, disease, and treatment factors. Critical Care Nursing Quarterly, 38(2), 200–210. doi:10.1097/CNQ.0000000000000062.PubMedCrossRef

37.

Tsigonis, A. M., Al-Hamadani, M., Linebarger, J. H., Vang, C. A., Krause, F. J., Johnson, J. M., et al. (2016). Are cure rates for breast cancer improved by local and regional anesthesia? Regional Anesthesia and Pain Medicine, 41(3), 339–347. doi:10.1097/AAP.0000000000000379.PubMedCrossRef

38.

Kairaluoma, P., Mattson, J., Heikkilä, P., Pere, P., & Leidenius, M. (2016). Perioperative paravertebral regional anaesthesia and breast cancer recurrence. Anticancer Research, 36(1), 415–418.PubMed

39.

Lin, L., Liu, C., Tan, H., Ouyang, H., Zhang, Y., & Zeng, W. (2011). Anaesthetic technique may affect prognosis for ovarian serous adenocarcinoma: a retrospective analysis. British Journal of Anaesthesia, 106, 814–822. doi:10.1093/bja/aer055.PubMedCrossRef

40.

de Oliveira Jr., G. S., Ahmad, S., Schink, J. C., Singh, D. K., Fitzgerald, P. C., & McCarthy, R. J. (2011). Intraoperative neuraxial anesthesia but not postoperative neuraxial analgesia is associated with increased relapse-free survival in ovarian cancer patients after primary cytoreductive surgery. Regional Anesthesia and Pain Medicine, 36, 271–277. doi:10.1097/AAP.0b013e318217aada.PubMedCrossRef

41.

Capmas, P., Billard, V., Gouy, S., Lhommé, C., Pautier, P., Morice, P., et al. (2012). Impact of epidural analgesia on survival in patients undergoing complete cytoreductive surgery for ovarian cancer. Anticancer Research, 32(4), 1537–1542.PubMed

42.

Elias, K. M., Kang, S., Liu, X., Horowitz, N. S., Berkowitz, R. S., & Frendl, G. (2015). Anesthetic selection and disease-free survival following optimal primary cytoreductive surgery for stage III epithelial ovarian cancer. Annals of Surgical Oncology, 22(4), 1341–1348. doi:10.1245/s10434-014-4112-9.PubMedCrossRef

43.

Lacassie, H. J., Cartagena, J., Brañes, J., Assel, M., & Echevarría, G. C. (2013). The relationship between neuraxial anesthesia and advanced ovarian cancer-related outcomes in the Chilean population. Anesthesia & Analgesia, 117(3), 653–660. doi:10.1213/ANE.0b013e3182a07046.CrossRef

44.

Christopherson, R., James, K. E., Tableman, M., Marshall, P., & Johnson, F. E. (2008). Long-term survival after colon cancer surgery: a variation associated with choice of anesthesia. Anesthesia & Analgesia, 107(1), 325–332. doi:10.1213/ane.0b013e3181770f55.CrossRef

45.

Holler, J. P., Ahlbrandt, J., Burkhardt, E., Gruss, M., Röhrig, R., Knapheide, J., et al. (2013). Peridural analgesia may affect long-term survival in patients with colorectal cancer after surgery (PACO-RAS-Study): an analysis of a cancer registry. Annals of Surgery, 258(6), 989–993. doi:10.1097/SLA.0b013e3182915f61.PubMedCrossRef

46.

Vogelaar, F. J., Abegg, R., van der Linden, J. C., Cornelisse, H. G., van Dorsten, F. R., Lemmens, V. E., et al. (2015). Epidural analgesia associated with better survival in colon cancer. International Journal of Colorectal Disease, 30(8), 1103–1107. doi:10.1007/s00384-015-2224-8.PubMedCrossRef

47.

Zimmitti, G., Soliz, J., Aloia, T. A., Gottumukkala, V., Cata, J. P., Tzeng, C. W., et al. (2016). Positive impact of epidural analgesia on oncologic outcomes in patients undergoing resection of colorectal liver metastases. Annals of Surgical Oncology, 23(3), 1003–1011. doi:10.1245/s10434-015-4933-1.PubMedCrossRef

48.

Gupta, A., Björnsson, A., Fredriksson, M., Hallböök, O., & Eintrei, C. (2011). Reduction in mortality after epidural anaesthesia and analgesia in patients undergoing rectal but not colonic cancer surgery: a retrospective analysis of data from 655 patients in central Sweden. British Journal of Anaesthesia, 107(2), 164–170. doi:10.1093/bja/aer100.PubMedCrossRef

49.

Cummings 3rd, K. C., Xu, F., Cummings, L. C., & Cooper, G. S. (2012). A comparison of epidural analgesia and traditional pain management effects on survival and cancer recurrence after colectomy: a population-based study. Anesthesiology, 116(4), 797–806. doi:10.1097/ALN.0b013e31824674f6.PubMedCrossRef

50.

Gottschalk, A., Ford, J. G., Regelin, C. C., You, J., Mascha, E. J., Sessler, D. I., et al. (2010). Association between epidural analgesia and cancer recurrence after colorectal cancer surgery. Anesthesiology, 113(1), 27–34. doi:10.1097/ALN.0b013e3181de6d0d.PubMedCrossRef

51.

Day, A., Smith, R., Jourdan, I., Fawcett, W., Scott, M., & Rockall, T. (2012). Retrospective analysis of the effect of postoperative analgesia on survival in patients after laparoscopic resection of colorectal cancer. British Journal of Anaesthesia, 109(2), 185–190. doi:10.1093/bja/aes106.PubMedCrossRef

52.

Merquiol, F., Montelimard, A. S., Nourissat, A., Molliex, S., & Zufferey, P. J. (2013). Cervical epidural anesthesia is associated with increased cancer-free survival in laryngeal and hypopharyngeal cancer surgery: a retrospective propensity-matched analysis. Regional Anesthesia and Pain Medicine, 38(5), 398–402. doi:10.1097/AAP.0b013e31829cc3fb.PubMedCrossRef

53.

Call, T. R., Pace, N. L., Thorup, D. B., Maxfield, D., Chortkoff, B., Christensen, J., et al. (2015). Factors associated with improved survival after resection of pancreatic adenocarcinoma: a multivariable model. Anesthesiology, 122(2), 317–324. doi:10.1097/ALN.0000000000000489.PubMedCrossRef

54.

Hiller, J. G., Hacking, M. B., Link, E. K., Wessels, K. L., & Riedel, B. J. (2014). Perioperative epidural analgesia reduces cancer recurrence after gastro-oesophageal surgery. Acta Anaesthesiologica Scandinavica, 58(3), 281–290. doi:10.1111/aas.12255.PubMedCrossRef

55.

Cao, L., Chang, Y., Lin, W., Zhou, J., Tan, H., Yuan, Y., et al. (2014). Long-term survival after resection of hepatocelluar carcinoma: a potential risk associated with the choice of postoperative analgesia. Anesthesia & Analgesia, 118(6), 1309–1316. doi:10.1213/ANE.0000000000000207.CrossRef

56.

Cummings 3rd, K. C., Patel, M., Htoo, P. T., Bakaki, P. M., Cummings, L. C., & Koroukian, S. (2014). A comparison of the effects of epidural analgesia versus traditional pain management on outcomes after gastric cancer resection: a population-based study. Regional Anesthesia and Pain Medicine, 39(3), 200–207. doi:10.1097/AAP.0000000000000079.PubMedPubMedCentralCrossRef

57.

Heinrich, S., Janitz, K., Merkel, S., Klein, P., & Schmidt, J. (2015). Short- and long term effects of epidural analgesia on morbidity and mortality of esophageal cancer surgery. Langenbeck’s Archives of Surgery, 400(1), 19–26. doi:10.1007/s00423-014-1248-9.PubMedCrossRef

58.

Biki, B., Mascha, E., Moriarty, D. C., Fitzpatrick, J. M., Sessler, D. I., & Buggy, D. J. (2008). Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis. Anesthesiology, 109, 180–187. doi:10.1097/ALN.0b013e31817f5b73.PubMedCrossRef

59.

Wuethrich, P. Y., Hsu Schmitz, S. F., Kessler, T. M., Thalmann, G. N., Studer, U. E., Stueber, F., et al. (2010). Potential influence of the anesthetic technique used during open radical prostatectomy on prostate cancer-related outcome: a retrospective study. Anesthesiology, 113(3), 570–576. doi:10.1097/ALN.0b013e3181e4f6ec.PubMed

60.

Tsui, B. C., Rashiq, S., Schopflocher, D., Murtha, A., Broemling, S., Pillay, J., et al. (2010). Epidural anesthesia and cancer recurrence rates after radical prostatectomy. Canadian Journal of Anesthesia, 57(2), 107–112. doi:10.1007/s12630-009-9214-7.PubMedCrossRef

61.

Forget, P., Tombal, B., Scholtès, J. L., Nzimbala, J., Meulders, C., Legrand, C., et al. (2011). Do intraoperative analgesics influence oncological outcomes after radical prostatectomy for prostate cancer? European Journal of Anaesthesiology, 28(12), 830–835. doi:10.1097/EJA.0b013e32834b7d9a.PubMedCrossRef

62.

Wuethrich, P. Y., Thalmann, G. N., Studer, U. E., & Burkhard, F. C. (2013). Epidural analgesia during open radical prostatectomy does not improve long-term cancer-related outcome: a retrospective study in patients with advanced prostate cancer. PloS One, 8(8), e72873. doi:10.1371/journal.pone.0072873.PubMedPubMedCentralCrossRef

63.

Sprung, J., Scavonetto, F., Yeoh, T. Y., Kramer, J. M., Karnes, R. J., Eisenach, J. H., et al. (2014). Outcomes after radical prostatectomy for cancer: a comparison between general anesthesia and epidural anesthesia with fentanyl analgesia: a matched cohort study. Anesthesia & Analgesia, 119(4), 859–866. doi:10.1213/ANE.0000000000000320.CrossRef

64.

Roiss, M., Schiffmann, J., Tennstedt, P., Kessler, T., Blanc, I., Goetz, A., et al. (2014). Oncological long-term outcome of 4772 patients with prostate cancer undergoing radical prostatectomy: does the anaesthetic technique matter? European Journal of Surgical Oncology, 40(12), 1686–1692. doi:10.1016/j.ejso.2014.02.223.PubMedCrossRef

65.

Scavonetto, F., Yeoh, T. Y., Umbreit, E. C., Weingarten, T. N., Gettman, M. T., Frank, I., et al. (2014). Association between neuraxial analgesia, cancer progression, and mortality after radical prostatectomy: a large, retrospective matched cohort study. British Journal of Anaesthesia, 113(Suppl 1), i95–102. doi:10.1093/bja/aet467.PubMedCrossRef

66.

Tseng, K. S., Kulkarni, S., Humphreys, E. B., Carter, H. B., Mostwin, J. L., Partin, A. W., et al. (2014). Spinal anesthesia does not impact prostate cancer recurrence in a cohort of men undergoing radical prostatectomy: an observational study. Regional Anesthesia and Pain Medicine, 39(4), 284–288. doi:10.1097/AAP.0000000000000108.PubMedPubMedCentralCrossRef

67.

Ehdaie, B., Sjoberg, D. D., Dalecki, P. H., Scardino, P. T., Eastham, J. A., & Amar, D. (2014). Association of anesthesia technique for radical prostatectomy with biochemical recurrence: a retrospective cohort study. Canadian Journal of Anesthesia, 61(12), 1068–1074. doi:10.1007/s12630-014-0221-y.PubMedCrossRef

68.

Kamuf, J., Pospich, M., & Heid, F. (2014). Cancer-free or overall survival rate following radical prostatectomy is not influenced by perioperative pain management. Journal of Anesthesia & Clinical Research, 5, 7. doi:10.4172/2155-6148.1000422.

69.

Jang, D., Lim, C. S., Shin, Y. S., Ko, Y. K., Park, S. I., Song, S. H., et al. (2016). A comparison of regional and general anesthesia effects on 5 year survival and cancer recurrence after transurethral resection of the bladder tumor: a retrospective analysis. BMC Anesthesiology, 16, 16. doi:10.1186/s12871-016-0181-6.PubMedPubMedCentralCrossRef

70.

Weingarten, T. N., Taccolini, A. M., Ahle, S. T., Dietz, K. R., Dowd, S. S., Frank, I., et al. (2016). Perioperative management and oncological outcomes following radical cystectomy for bladder cancer: a matched retrospective cohort study. Canadian Journal of Anesthesia, 63(5), 584–595. doi:10.1007/s12630-016-0599-9.PubMedCrossRef

71.

Cata, J. P., Gottumukkala, V., Thakar, D., Keerty, D., Gebhardt, R., & Liu, D. D. (2014). Effects of postoperative epidural analgesia on recurrence-free and overall survival in patients with nonsmall cell lung cancer. See comment in PubMed Commons below Journal of Clinical Anesthesia, 26(1), 3–17. doi:10.1016/j.jclinane.2013.06.007.PubMedCrossRef

72.

Maher, D. P., Wong, W., White, P. F., McKenna Jr., R., Rosner, H., Shamloo, B., et al. (2014). Association of increased postoperative opioid administration with non-small-cell lung cancer recurrence: a retrospective analysis. British Journal of Anaesthesia, 113(Suppl 1), i88–i94. doi:10.1093/bja/aeu192.PubMedCrossRef

73.

Myles, P. S., Peyton, P., Silbert, B., Hunt, J., Rigg, J. R., Sessler, D. I., & ANZCA Trials Group Investigators (2011). Perioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial. British Medical Journal, 342, d1491. doi:10.1136/bmj.d1491.PubMedCrossRef

74.

Binczak, M., Tournay, E., Billard, V., Rey, A., & Jayr, C. (2013). Major abdominal surgery for cancer: does epidural analgesia have a long-term effect on recurrence-free and overall survival? Annales Françaises d’Anesthésie et de Réanimation, 32(5), e81–e88. doi:10.1016/j.annfar.2013.02.027.PubMedCrossRef

75.

Schlagenhauff, B., Ellwanger, U., Breuninger, H., Stroebel, W., Rassner, G., & Garbe, C. (2000). Prognostic impact of the type of anaesthesia used during the excision of primary cutaneous melanoma. Melanoma Research, 10(2), 165–169.PubMedCrossRef

76.

Gottschalk, A., Brodner, G., Van Aken, H. K., Ellger, B., Althaus, S., & Schulze, H. J. (2012). Can regional anaesthesia for lymph-node dissection improve the prognosis in malignant melanoma? British Journal of Anaesthesia, 109(2), 253–259. doi:10.1093/bja/aes176.PubMedCrossRef

77.

Chen, W. K., & Miao, C. H. (2013). The effect of anesthetic technique on survival in human cancers: a meta-analysis of retrospective and prospective studies. PloS One, 8(2), e56540. doi:10.1371/journal.pone.0056540.PubMedPubMedCentralCrossRef

78.

Cakmakkaya, O. S., Kolodzie, K., Apfel, C. C., & Pace, N. L. (2014). Anaesthetic techniques for risk of malignant tumour recurrence. Cochrane Database of Systematic Reviews, 11, CD008877. doi:10.1002/14651858.CD008877.pub2.

79.

Pei, L., Tan, G., Wang, L., Guo, W., Xiao, B., Gao, X., et al. (2014). Comparison of combined general-epidural anesthesia with general anesthesia effects on survival and cancer recurrence: a meta-analysis of retrospective and prospective studies. PloS One, 9(12), e114667. doi:10.1371/journal.pone.0114667.PubMedPubMedCentralCrossRef

80.

Sun, Y., Li, T., & Gan, T. J. (2015). The effects of perioperative regional anesthesia and analgesia on cancer recurrence and survival after oncology surgery: a systematic review and meta-analysis. Regional Anesthesia and Pain Medicine, 40(5), 589–598. doi:10.1097/AAP.0000000000000273.PubMedCrossRef

81.

Sun, X., Yang, C., Li, K., & Ding, S. (2015). The impact of anesthetic techniques on survival for patients with colorectal cancer: evidence based on six studies. Hepato-Gastroenterology, 62(138), 299–302.PubMed

82.

Lee, B. M., Singh Ghotra, V., Karam, J. A., Hernandez, M., Pratt, G., & Cata, J. P. (2015). Regional anesthesia/analgesia and the risk of cancer recurrence and mortality after prostatectomy: a meta-analysis. Pain Management, 5(5), 387–595. doi:10.2217/pmt.15.30.PubMedCrossRef

83.

Weng, M., Chen, W., Hou, W., Li, L., Ding, M., & Miao, C. (2016). The effect of neuraxial anesthesia on cancer recurrence and survival after cancer surgery: an updated meta-analysis. Oncotarget, 7(12), 15262–15273. doi:10.18632/oncotarget.7683.PubMedPubMedCentral

84.

Enlund, M., Berglund, A., Andreasson, K., Cicek, C., Enlund, A., & Bergkvist, L. (2014). The choice of anaesthetic—sevoflurane or propofol—and outcome from cancer surgery: a retrospective analysis. Upsala Journal of Medical Sciences, 119(3), 251–261. doi:10.3109/03009734.2014.922649.PubMedPubMedCentralCrossRef

85.

Lee, J. H., Kang, S. H., Kim, Y., Kim, H. A., & Kim, B. S. (2016). Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study. Korean Journal of Anesthesiology, 69(2), 126–132. doi:10.4097/kjae.2016.69.2.126.PubMedPubMedCentralCrossRef

86.

Wigmore, T. J., Mohammed, K., & Jhanji, S. (2016). Long-term survival for patients undergoing volatile versus IV anesthesia for cancer surgery: a retrospective analysis. Anesthesiology, 124(1), 69–79. doi:10.1097/ALN.0000000000000936.PubMedCrossRef

87.

Sessler, D. I., Ben-Eliyahu, S., Mascha, E. J., Parat, M. O., & Buggy, D. J. (2008). Can regional analgesia reduce the risk of recurrence after breast cancer? Methodology of a multicenter randomized trial. Contemporary Clinical Trials, 29(4), 517–526. doi:10.1016/j.cct.2008.01.002.PubMedCrossRef

88.

Zetter, B. R. (1998). Angiogenesis and tumor metastasis. Annual Review of Medicine, 49, 407–424.PubMedCrossRef

89.

Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., et al. (2006). The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nature Reviews Cancer, 6(3), 240–248.PubMedPubMedCentralCrossRef

90.

Kurosawa, S. (2012). Anesthesia in patients with cancer disorders. Current Opinion in Anesthesiology, 25(3), 376–384. doi:10.1097/ACO.0b013e328352b4a8.PubMedCrossRef

91.

Sacerdote, P., Bianchi, M., Gaspani, L., Manfredi, B., Maucione, A., Terno, G., et al. (2000). The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients. Anesthesia & Analgesia, 90(6), 1411–1414.CrossRef

92.

Ben-Eliyahu, S., Page, G. G., Yirmiya, R., & Shakhar, G. (1999). Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity. International Journal of Cancer, 80(6), 880–888.PubMedCrossRef

93.

Chae, B. K., Lee, H. W., Sun, K., Choi, Y. H., & Kim, H. M. (1998). The effect of combined epidural and light general anesthesia on stress hormones in open heart surgery patients. Surgery Today, 28(7), 727–731.PubMedCrossRef

94.

Gupta, K., Kshirsagar, S., Chang, L., Schwartz, R., Law, P. Y., Yee, D., et al. (2002). Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Research, 62(15), 4491–4498.PubMed

95.

Singhal, P. C., Sharma, P., Kapasi, A. A., Reddy, K., Franki, N., & Gibbons, N. (1998). Morphine enhances macrophage apoptosis. Journal of Immunology, 160(4), 1886–1893.

96.

Hatzoglou, A., Bakogeorgou, E., & Castanas, E. (1996). The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors. European Journal of Pharmacology, 296(2), 199–207.PubMedCrossRef

97.

Lin, X., Wang, Y. J., Li, Q., Hou, Y. Y., Hong, M. H., Cao, Y. L., et al. (2009). Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway. Federation of European Biochemical Societies Journal, 276(7), 2022–2036. doi:10.1111/j.1742-4658.2009.06938.x.PubMed

98.

Singleton, P. A., Mirzapoiazova, T., Hasina, R., Salgia, R., & Moss, J. (2014). Increased μ-opioid receptor expression in metastatic lung cancer. British Journal of Anaesthesia, 113(Suppl 1), i103–i108. doi:10.1093/bja/aeu165.PubMedPubMedCentralCrossRef

99.

Bimonte, S., Barbieri, A., Rea, D., Palma, G., Luciano, A., Cuomo, A., et al. (2015). Morphine promotes tumor angiogenesis and increases breast cancer progression. BioMed Research International, 2015, 161508. doi:10.1155/2015/161508.PubMedPubMedCentral

100.

Page, G. G., Ben-Eliyahu, S., Yirmiya, R., & Liebeskind, J. C. (1993). Morphine attenuates surgery-induced enhancement of metastatic colonization in rats. Pain, 54(1), 21–28.PubMedCrossRef

101.

Page, G. G., McDonald, J. S., & Ben-Eliyahu, S. (1998). Pre-operative versus postoperative administration of morphine: impact on the neuroendocrine, behavioural, and metastatic-enhancing effects of surgery. British Journal of Anaesthesia, 81(2), 216–223.PubMedCrossRef

102.

Li, A. X., Xin, W. Q., & Ma, C. G. (2015). Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR. Biochemical and Biophysical Research Communications, 465(3), 594–600. doi:10.1016/j.bbrc.2015.08.068.PubMedCrossRef

103.

Juneja, R. (2014). Opioids and cancer recurrence. Current Opinion in Supportive and Palliative Care, 8(2), 91–101. doi:10.1097/SPC.0000000000000056.PubMedCrossRef

104.

Chen, W. K., Ren, L., Wei, Y., Zhu, D. X., Miao, C. H., & Xu, J. M. (2015). General anesthesia combined with epidural anesthesia ameliorates the effect of fast-track surgery by mitigating immunosuppression and facilitating intestinal functional recovery in colon cancer patients. International Journal of Colorectal Disease, 30(4), 475–481. doi:10.1007/s00384-014-2098-1.PubMedCrossRef

105.

Xu, Y. J., Chen, W. K., Zhu, Y., Wang, S. L., & Miao, C. H. (2014). Effect of thoracic epidural anaesthesia on serum vascular endothelial growth factor C and cytokines in patients undergoing anaesthesia and surgery for colon cancer. British Journal of Anaesthesia, 113(Suppl 1), i49–i55. doi:10.1093/bja/aeu148.PubMedCrossRef

106.

Xu, Y. J., Li, S. Y., Cheng, Q., Chen, W. K., Wang, S. L., Ren, Y., et al. (2016). Effects of anaesthesia on proliferation, invasion and apoptosis of LoVo colon cancer cells in vitro. Anaesthesia, 71(2), 147–154. doi:10.1111/anae.13331.PubMedCrossRef

107.

Sultan, S. S. (2013). Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries. Saudi Journal of Anaesthesia, 7(4), 373–377. doi:10.4103/1658-354X.121043.PubMedPubMedCentralCrossRef

108.

Desmond, F., McCormack, J., Mulligan, N., Stokes, M., & Buggy, D. J. (2015). Effect of anaesthetic technique on immune cell infiltration in breast cancer: a follow-up pilot analysis of a prospective, randomised, investigator-masked study. Anticancer Research, 35(3), 1311–1319.PubMed

109.

Jaura, A. I., Flood, G., Gallagher, H. C., & Buggy, D. J. (2014). Differential effects of serum from patients administered distinct anaesthetic techniques on apoptosis in breast cancer cells in vitro: a pilot study. British Journal of Anaesthesia, 113(Suppl 1), i63–i67. doi:10.1093/bja/aet581.PubMedCrossRef

110.

Buckley, A., McQuaid, S., Johnson, P., & Buggy, D. J. (2014). Effect of anaesthetic technique on the natural killer cell anti-tumour activity of serum from women undergoing breast cancer surgery: a pilot study. See comment in PubMed Commons below British Journal of Anaesthesia, 113(Suppl 1), i56–i62. doi:10.1093/bja/aeu200.PubMedCrossRef

Title: Anesthetic technique and cancer recurrence in oncologic surgery: unraveling the puzzle
Author: Ryungsa. Kim
Publication date: 01-03-2017
Publisher: Springer US
Published in: Cancer and Metastasis Reviews / Issue 1/2017
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-016-9647-8

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