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AIDS and Behavior
Published in: AIDS and Behavior 10/2021

01-10-2021 | Human Immunodeficiency Virus | Original Paper

Effects of Age, Level of Education and HIV Status on Cognitive Performance in West African Older Adults: The West Africa IeDEA Cohort Collaboration

Authors: C. Bernard, H. Font, Z. Diallo, R. Ahonon, J. M. Tine, F. N. Abouo, A. Tanon, E. Messou, M. Seydi, F. Dabis, J.-F. Dartigues, N. de Rekeneire, the IeDEA West Africa Cohort Collaboration

Published in: AIDS and Behavior | Issue 10/2021

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Abstract

An in-depth understanding of the impact of aging, cognitive reserve, and HIV status on cognitive function is needed in older West African adults. Ninety-nine HIV-negative and 334 HIV-positive adults aged ≥ 50 years were enrolled in three clinics (Senegal and Côte d’Ivoire) participating in the IeDEA West Africa collaboration. All subjects underwent the Free and Cued Selective Reminding Test (FCSRT) and the Isaacs Set Test (IST). Age (both linear and quadratic), education level, and HIV status effects on Z-scores were assessed using multivariate linear regression models. Interactions between HIV status and age or educational level were tested. In the present cohort of older West African adults, the role of age and educational level on episodic memory and verbal fluency was observed without revealing an interaction between HIV status and age effect. As age had quadratic effects, older HIV-positive adults should not be considered as a unique group irrespective of their age. Low-educated HIV-positive patients had the lowest verbal fluency performance compared to others. Further studies are needed to duplicate these results. In clinical settings, screening and adapted programs focusing on improving cognition in those patients are needed.
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Literature
1.
Heaton RK, Clifford DB, Franklin DR, Woods SP, Ake C, Vaida F, et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology. 2010;75:2087–96.PubMedPubMedCentralCrossRef
2.
Cholewińska G, Szymańska B. Mental impairment and neurocognitive symptoms associated with HIV infection. HIV AIDS Rev. 2009;8:9–14.CrossRef
3.
Vance DE, Fazeli PL, Ross LA, Wadley VG, Ball KK. Speed of processing training with middle-age and older adults with HIV: a pilot study. J Assoc Nurses AIDS Care JANAC. 2012;23:500–10.PubMedCrossRef
4.
Habib AG, Yakasai AM, Owolabi LF, Ibrahim A, Habib ZG, Gudaji M, et al. Neurocognitive impairment in HIV-1-infected adults in Sub-Saharan Africa: a systematic review and meta-analysis. Int J Infect Dis. 2013;17:e820–31.PubMedCrossRef
5.
Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, LeBlanc S, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2011;17:3–16.PubMedCrossRef
6.
Hinkin CH, Hardy DJ, Mason KI, Castellon SA, Durvasula RS, Lam MN, et al. Medication adherence in HIV-infected adults: effect of patient age, cognitive status, and substance abuse. AIDS Lond Engl. 2004;18(Suppl 1):S19-25.CrossRef
7.
Tozzi V, Balestra P, Serraino D, Bellagamba R, Corpolongo A, Piselli P, et al. Neurocognitive impairment and survival in a cohort of HIV-infected patients treated with HAART. AIDS Res Hum Retroviruses. 2005;21:706–13.PubMedCrossRef
8.
Rusch M, Nixon S, Schilder A, Braitstein P, Chan K, Hogg RS. Impairments, activity limitations and participation restrictions: prevalence and associations among persons living with HIV/AIDS in British Columbia. Health Qual Life Outcomes. 2004;2:46.PubMedPubMedCentralCrossRef
9.
van Gorp WG, Baerwald JP, Ferrando SJ, McElhiney MC, Rabkin JG. The relationship between employment and neuropsychological impairment in HIV infection. J Int Neuropsychol Soc JINS. 1999;5:534–9.PubMedCrossRef
10.
Kordovski VM, Woods SP, Verduzco M, Beltran J. The effects of aging and HIV disease on employment status and functioning. Rehabil Psychol. 2017;62:591–9.PubMedPubMedCentralCrossRef
11.
Becker JT, Lopez OL, Dew MA, Aizenstein HJ. Prevalence of cognitive disorders differs as a function of age in HIV virus infection. AIDS Lond Engl. 2004;18(Suppl 1):S11–18.CrossRef
12.
13.
Cysique LA, Maruff P, Bain MP, Wright E, Brew BJ. HIV and age do not substantially interact in HIV-associated neurocognitive impairment. J Neuropsychiatry Clin Neurosci. 2011;23:83–9.PubMedCrossRef
14.
Cohen RA, Seider TR, Navia B. HIV effects on age-associated neurocognitive dysfunction: premature cognitive aging or neurodegenerative disease? Alzheimers Res Ther. 2015;7:37.PubMedPubMedCentralCrossRef
15.
Ances BM, Ortega M, Vaida F, Heaps J, Paul R. Independent effects of HIV, Aging, and HAART on brain volumetric measures: JAIDS. J Acquir Immune Defic Syndr. 2012;59:469–77.PubMedPubMedCentralCrossRef
16.
Seider TR, Luo X, Gongvatana A, Devlin KN, de la Monte SM, Chasman JD, et al. Verbal memory declines more rapidly with age in HIV infected versus uninfected adults. J Clin Exp Neuropsychol. 2014;36:356–67.PubMedPubMedCentralCrossRef
17.
Cysique LA, Brew BJ. The effects of HIV and aging on brain functions: proposing a research framework and update on last 3 years’ findings. Curr Opin HIV AIDS. 2014;9:355–64.PubMedCrossRef
18.
Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc JINS. 2002;8:448–60.PubMedCrossRef
19.
Ostrosky-Solis F, Ardila A, Rosselli M, Lopez-Arango G, Uriel-Mendoza V. Neuropsychological test performance in illiterate subjects. Arch Clin Neuropsychol. 1998;13:645–60.PubMedCrossRef
20.
Le Carret N, Lafont S, Mayo W, Fabrigoule C. The effect of education on cognitive performances and its implication for the constitution of the cognitive reserve. Dev Neuropsychol. 2003;23:317–37.PubMedCrossRef
21.
Bornstein RA, Suga LJ. Educational level and neuropsychological performance in healthy elderly subjects. Dev Neuropsychol. 1988;4:17–22.CrossRef
22.
Holguin A, Banda M, Willen EJ, Malama C, Chiyenu KO, Mudenda VC, et al. HIV-1 effects on neuropsychological performance in a resource-limited country, Zambia. AIDS Behav. 2011;15:1895–901.PubMedPubMedCentralCrossRef
23.
Joska JA, Fincham DS, Stein DJ, Paul RH, Seedat S. Clinical correlates of HIV-associated neurocognitive disorders in South Africa. AIDS Behav. 2010;14:371–8.PubMedCrossRef
24.
Lawler K, Jeremiah K, Mosepele M, Ratcliffe SJ, Cherry C, Seloilwe E, et al. Neurobehavioral effects in HIV-positive individuals receiving highly active antiretroviral therapy (HAART) in Gaborone, Botswana. Myer L, editor. PLoS ONE. 2011;6:e17233.PubMedPubMedCentralCrossRef
25.
Lawler K, Mosepele M, Ratcliffe S, Seloilwe E, Steele K, Nthobatsang R, et al. Neurocognitive impairment among HIV-positive individuals in Botswana: a pilot study. J Int AIDS Soc. 2010;13:15.PubMedPubMedCentralCrossRef
26.
Patel VN, Mungwira RG, Tarumbiswa TF, Heikinheimo T, van Oosterhout JJ. High prevalence of suspected HIV-associated dementia in adult Malawian HIV patients. Int J STD AIDS. 2010;21:356–8.PubMedCrossRef
27.
Wong MH, Robertson K, Nakasujja N, Skolasky R, Musisi S, Katabira E, et al. Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa. Neurology. 2007;68:350–5.PubMedCrossRef
28.
Sheppard DP, Woods SP, Bondi MW, Gilbert PE, Massman PJ, Doyle KL, et al. Does older age confer an increased risk of incident neurocognitive disorders among persons living with HIV disease? Clin Neuropsychol. 2015;29:656–77.PubMedPubMedCentralCrossRef
29.
Ryan EL, Baird R, Mindt MR, Byrd D, Monzones J, Bank SM, et al. Neuropsychological impairment in racial/ethnic minorities with HIV infection and low literacy levels: effects of education and reading level in participant characterization. J Int Neuropsychol Soc JINS. 2005;11:889–98.PubMedCrossRef
30.
Grober E, Lipton RB, Hall C, Crystal H. Memory impairment on free and cued selective reminding predicts dementia. Neurology. 2000;54:827–32.PubMedCrossRef
31.
Grober E, Hall CB, Lipton RB, Zonderman AB, Resnick SM, Kawas C. Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer’s disease. J Int Neuropsychol Soc JINS. 2008;14:266–78.PubMed
32.
Amieva H, Le Goff M, Millet X, Orgogozo JM, Pérès K, Barberger-Gateau P, et al. Prodromal Alzheimer’s disease: successive emergence of the clinical symptoms. Ann Neurol. 2008;64:492–8.PubMedCrossRef
33.
Hall CB, Lipton RB, Sliwinski M, Stewart WF. A change point model for estimating the onset of cognitive decline in preclinical Alzheimer’s disease. Stat Med. 2000;19:1555–66.PubMedCrossRef
34.
Crossley M, D’Arcy C, Rawson NS. Letter and category fluency in community-dwelling Canadian seniors: a comparison of normal participants to those with dementia of the Alzheimer or vascular type. J Clin Exp Neuropsychol. 1997;19:52–62.PubMedCrossRef
35.
Auriacombe S, Fabrigoule C, Lafont S, Jacqmin-Gadda H, Dartigues J-F. Letter and category fluency in normal elderly participants: a population-based study. Aging Neuropsychol Cogn. 2001;8:98–108.CrossRef
36.
Iudicello JE, Woods SP, Deutsch R, Grant I. The HIV neurobehavioral research Pr. combined effects of aging and HIV infection on semantic verbal fluency: a view of the cortical hypothesis through the lens of clustering and switching. J Clin Exp Neuropsychol. 2012;34:476–88.PubMedPubMedCentralCrossRef
37.
Goodkin K, Miller EN, Cox C, Reynolds S, Becker JT, Martin E, et al. Effect of ageing on neurocognitive function by stage of HIV infection: evidence from the Multicenter AIDS Cohort Study. Lancet HIV. 2017;4:e411–22.PubMedPubMedCentralCrossRef
38.
39.
Egger M, Ekouevi DK, Williams C, Lyamuya RE, Mukumbi H, Braitstein P, et al. Cohort Profile: the international epidemiological databases to evaluate AIDS (IeDEA) in sub-Saharan Africa. Int J Epidemiol. 2012;41:1256–64.PubMedCrossRef
40.
41.
Guerchet M, Mbelesso P, Ndamba-Bandzouzi B, Pilleron S, Desormais I, et al. Epidemiology of dementia in Central Africa (EPIDEMCA): protocol for a multicentre population-based study in rural and urban areas of the Central African Republic and the Republic of Congo. Springerplus. 2014;3:1044.PubMedCentralCrossRef
42.
43.
Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. 1977;1:385–401.
44.
Fuhrer R, Rouillon F. The French version of the Center for Epidemiologic Studies. Depression Scale. 1989;4(3):163–6.
45.
Mohamed AA, Oduor C, Kinyanjui D. HIV-associated neurocognitive disorders at Moi teaching and referral hospital, Eldoret. Kenya. BMC Neurol. 2020;20:280.PubMedPubMedCentralCrossRef
46.
Sanmartí M, Meyer A, Jaen A, Robertson K, Tan N, Mapesi H, et al. HIV‐associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania. HIV Med. 2020;hiv.12979.
47.
Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology. 2007;69:1789–99.PubMedCrossRef
48.
Kabuba N, Menon JA, Franklin DR, Lydersen S, Heaton RK, Hestad KA. Effect of age and level of education on neurocognitive impairment in HIV positive Zambian adults. Neuropsychology. 2018;32:519–28.PubMedPubMedCentralCrossRef
49.
Rodriguez-Penney AT, Iudicello JE, Riggs PK, Doyle K, Ellis RJ, Letendre SL, et al. Co-morbidities in persons infected with HIV: increased burden with older age and negative effects on health-related quality of life. AIDS Patient Care STDs. 2013;27:5–16.PubMedPubMedCentralCrossRef
50.
Mindt MR, Miranda C, Arentoft A, Byrd D, Monzones J, Fuentes A, et al. Aging and HIV/AIDS: neurocognitive implications for older HIV-positive Latina/o Adults. Behav Med. 2014;40:116–23.PubMedCrossRef
51.
Rubin EH, Storandt M, Miller JP, Kinscherf DA, Grant EA, Morris JC, et al. A prospective study of cognitive function and onset of dementia in cognitively healthy elders. Arch Neurol. 1998;55:395–401.PubMedCrossRef
52.
Valcour V, Paul R, Neuhaus J, Shikuma C. The effects of age and HIV on neuropsychological performance. J Int Neuropsychol Soc. 2011;17:190–5.PubMedCrossRef
53.
Hardy DJ, Vance DE. The neuropsychology of HIV/AIDS in older adults. Neuropsychol Rev. 2009;19:263–72.PubMedCrossRef
54.
Milanini B, Valcour V. Differentiating HIV-associated neurocognitive disorders from Alzheimer’s disease: an emerging issue in geriatric NeuroHIV. Curr HIV/AIDS Rep. 2017;14:123–32.PubMedPubMedCentralCrossRef
55.
DeVaughn S, Müller-Oehring EM, Markey B, Brontë-Stewart HM, Schulte T. Aging with HIV-1 infection: motor functions, cognition, and attention – a comparison with Parkinson’s disease. Neuropsychol Rev. 2015;25:424–38.PubMedPubMedCentralCrossRef
56.
Kanmogne GD, Kuate CT, Cysique LA, Fonsah JY, Eta S, Doh R, et al. HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon. BMC Neurol. 2010;10:60.PubMedPubMedCentralCrossRef
57.
Joska JA, Dreyer AJ, Nightingale S, Combrinck MI, De Jager CA. Prevalence of HIV-1 Infection in an elderly rural population and associations with neurocognitive impairment. AIDS Lond Engl. 2019;33:1765–71.CrossRef
58.
Grasset L, Jacqmin-Gadda H, Proust-Lima C, Pérès K, Amieva H, Dartigues J-F, et al. Temporal trends in the level and decline of cognition and disability in an elderly population: the PAQUID study. Am J Epidemiol. 2018;187:2168–76.PubMedCrossRef
59.
Bernard C, Balestre E, Coffie PA, Eholie SP, Messou E, Kwaghe V, et al. Aging with HIV: what effect on mortality and loss to follow-up in the course of antiretroviral therapy? The IeDEA West Africa Cohort Collaboration. HIVAIDS Auckl NZ. 2018;10:239–52.
Metadata
Title
Effects of Age, Level of Education and HIV Status on Cognitive Performance in West African Older Adults: The West Africa IeDEA Cohort Collaboration
Authors
C. Bernard
H. Font
Z. Diallo
R. Ahonon
J. M. Tine
F. N. Abouo
A. Tanon
E. Messou
M. Seydi
F. Dabis
J.-F. Dartigues
N. de Rekeneire
the IeDEA West Africa Cohort Collaboration
Publication date
01-10-2021
Publisher
Springer US
Published in
AIDS and Behavior / Issue 10/2021
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-021-03309-6

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