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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-10-2020 | Sciatica | Research Article

T2 mapping of the distal sciatic nerve in healthy subjects and patients suffering from lumbar disc herniation with nerve compression

Authors: Nico Sollmann, Dominik Weidlich, Elisabeth Klupp, Barbara Cervantes, Carl Ganter, Claus Zimmer, Ernst J. Rummeny, Thomas Baum, Jan S. Kirschke, Dimitrios C. Karampinos

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 5/2020

Abstract

Objective

To measure T2 values for magnetic resonance neurography (MRN) of the healthy distal sciatic nerve and compare those to T2 changes in patients with nerve compression.

Materials and methods

Twenty-one healthy subjects and five patients with sciatica due to disc herniation underwent MRN using a T2-prepared turbo spin echo (TSE) sequence of the distal sciatic nerve bilaterally. Six and one of those healthy subjects further underwent a commonly used multi-echo spin-echo (MESE) sequence and magnetic resonance spectroscopy (MRS), respectively.

Results

T2 values derived from the T2-prepared TSE sequence were 44.6 ± 3.0 ms (left) and 44.5 ± 2.6 ms (right) in healthy subjects and showed good inter-reader reliability. In patients, T2 values of 61.5 ± 6.2 ms (affected side) versus 43.3 ± 2.4 ms (unaffected side) were obtained. T2 values of MRS were in good agreement with measurements from the T2-prepared TSE, but not with those of the MESE sequence.

Discussion

A T2-prepared TSE sequence enables precise determination of T2 values of the distal sciatic nerve in agreement with MRS. A MESE sequence tends to overestimate nerve T2 compared to T2 from MRS due to the influence of residual fat on T2 quantification. Our approach may enable to quantitatively assess direct nerve affection related to nerve compression.

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Title: T2 mapping of the distal sciatic nerve in healthy subjects and patients suffering from lumbar disc herniation with nerve compression
Authors: Nico Sollmann
Dominik Weidlich
Elisabeth Klupp
Barbara Cervantes
Carl Ganter
Claus Zimmer
Ernst J. Rummeny
Thomas Baum
Jan S. Kirschke
Dimitrios C. Karampinos
Publication date: 01-10-2020
Publisher: Springer International Publishing
Keywords: Sciatica
Disc Herniation
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 5/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-020-00832-w

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

T2 mapping of the distal sciatic nerve in healthy subjects and patients suffering from lumbar disc herniation with nerve compression

Abstract

Objective

Materials and methods

Results

Discussion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Materials and methods

Results

Discussion

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