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European Radiology
Published in: European Radiology 3/2018

01-03-2018 | Neuro

MR T2 value of the tibial nerve can be used as a potential non-invasive and quantitative biomarker for the diagnosis of diabetic peripheral neuropathy

Authors: Dongye Wang, Chuan Wang, Xiaohui Duan, Zehong Yang, Zhiqiang Bai, Huijun Hu, Li Yan, Jun Shen

Published in: European Radiology | Issue 3/2018

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Abstract

Objective

To determine the role of quantitative tibial nerve T2 value in the diagnosis of diabetic peripheral neuropathy (DPN).

Methods

MR imaging and T2 mapping of the tibial nerve were performed in 22 diabetic patients with DPN, 20 diabetic patients without DPN and 20 healthy controls. Nerve T2 values were measured, and compared using the Mann-Whitney U test. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic ability of T2 value to identify DPN.

Results

Nerve T2 value was 55.06 ± 4.05 ms, 48.91 ± 3.06 ms and 45.61 ± 1.86 ms in patients with DPN, patients without DPN and controls, respectively. Patients with DPN had significantly higher nerve T2 values than patients without DPN (P < 0.001). Nerve T2 values in patients without DPN were higher than in controls (P < 0.001). ROC analysis showed that T2 values had a diagnostic sensitivity of 81.8 %, specificity of 89.2 % and area under the curve of 0.922 for identifying patients with DPN from patients without DPN plus controls when the cutoff point was 51.34 ms.

Conclusion

T2 value of the tibial nerve can be used as an alternative, non-invasive quantitative parameter to assess DPN in diabetic patients.

Key points

• Tibial nerves in patients with DPN showed T2 hyperintensity and enlargement.
• Tibial nerves in patients with DPN had an increased T2 value.
• T2 value might be used as a quantitative biomarker for DPN.
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Metadata
Title
MR T2 value of the tibial nerve can be used as a potential non-invasive and quantitative biomarker for the diagnosis of diabetic peripheral neuropathy
Authors
Dongye Wang
Chuan Wang
Xiaohui Duan
Zehong Yang
Zhiqiang Bai
Huijun Hu
Li Yan
Jun Shen
Publication date
01-03-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 3/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5043-1

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