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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-10-2020 | Research Article

Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization

Authors: Karina López, Radhouene Neji, Rahul K. Mukherjee, John Whitaker, Alkystis Phinikaridou, Reza Razavi, Claudia Prieto, Sébastien Roujol, René Botnar

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 5/2020

Abstract

Objective

To develop a three-dimensional (3D) high-resolution free-breathing magnetization transfer ratio (MTR) sequence for contrast-free assessment of myocardial infarct and coronary vein anatomy.

Materials and methods

Two datasets with and without off-resonance magnetization transfer preparation were sequentially acquired to compute MTR. 2D image navigators enabled beat-to-beat translational and bin-to-bin non-rigid motion correction. Two different imaging sequences were explored. MTR scar localization was compared against 3D late gadolinium enhancement (LGE) in a porcine model of myocardial infarction. MTR variability across the left ventricle and vessel sharpness in the coronary veins were evaluated in healthy human subjects.

Results

A decrease in MTR was observed in areas with LGE in all pigs (non-infarct: 25.1 ± 1.7% vs infarct: 16.8 ± 1.9%). The average infarct volume overlap on MTR and LGE was 62.5 ± 19.2%. In humans, mean MTR in myocardium was between 37 and 40%. Spatial variability was between 15 and 20% of the mean value. 3D whole heart MT-prepared datasets enabled coronary vein visualization with up to 8% improved vessel sharpness for non-rigid compared to translational motion correction.

Discussion

MTR and LGE showed agreement in infarct detection and localization in a swine model. Free-breathing 3D MTR maps are feasible in humans but high spatial variability was observed. Further clinical studies are warranted.

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Title: Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization
Authors: Karina López
Radhouene Neji
Rahul K. Mukherjee
John Whitaker
Alkystis Phinikaridou
Reza Razavi
Claudia Prieto
Sébastien Roujol
René Botnar
Publication date: 01-10-2020
Publisher: Springer International Publishing
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 5/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-020-00833-9

At a glance: The STEP trials

Springer Medicine

Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization

Abstract

Objective

Materials and methods

Results

Discussion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Discussion

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