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01-06-2020 | Cerebral Small Vessel Disease | Original Article

Decreased visible deep medullary veins is a novel imaging marker for cerebral small vessel disease

Authors: Xiaodong Chen, Lei Wei, Jihui Wang, Yilong Shan, Wei Cai, Xuejiao Men, Sanxin Liu, Zhuang Kang, Zhengqi Lu, Vincent C. T. Mok, Aimin Wu

Published in: Neurological Sciences | Issue 6/2020

Abstract

Purpose

Visibility of deep medullary veins (DMVs) seen at SWI is predictive of poor prognosis in ischemic stroke. Few attentions have been paid to DMVs in atherosclerotic cerebral small vessel disease (aCSVD) which is attributed to long-term imbalanced microhemodynamics. We conducted this retrospective study to explore the association between DMVs profiles and aCSVD risk factors, neuroimaging markers.

Methods

Two hundred and two patients identified as aCSVD from January 2017 to March 2019 were included in the study. Their demographic, clinical, laboratory, and neuroimaging data were reviewed. The quantity and morphology of DMVs were assessed with a 5-grade (range 0~4) visual rating scale. Total CSVD burden was calculated with an ordinal “SVD score” (range 0~4). Spearman rank correlation and multivariable logistic regression analysis were performed to determine the association between DMV scale and CSVD markers.

Results

DMV scale showed strong positive correlation with CSVD burden (r_s = 0.629, P < 0.001). Age (OR 1.078, 95% CI 1.015–1.145, P = 0.015) and hypertension (OR 2.629, 95% CI 1.024–6.749, P = 0.045) were two demographic risk factors for high DMV scale. Among CSVD neuroimaging markers, periventricular WMH (OR 2.925, 95% CI 1.464–5.845, P = 0.002), deep WMH (OR 2.872, 95% CI 1.174–7.022, P = 0.021), lacunae (OR 1.961, 95% CI 1.181–3.254, P = 0.009), and cerebral atrophy (OR 2.046, 95% CI 1.079–3.880, P = 0.028) were associated with high DMV scale after adjusting for clinical and metabolic confounders.

Conclusion

Multifactorial association between DMV scale and epidemiological, radiological contributors of aCSVD suggests DMV’s involved pathomechanism may participate in aCSVD development. Attach importance to DMV radiological profile in aCSVD will provide more neuroimaging information for diagnosis and prognosis.

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Title: Decreased visible deep medullary veins is a novel imaging marker for cerebral small vessel disease
Authors: Xiaodong Chen
Lei Wei
Jihui Wang
Yilong Shan
Wei Cai
Xuejiao Men
Sanxin Liu
Zhuang Kang
Zhengqi Lu
Vincent C. T. Mok
Aimin Wu
Publication date: 01-06-2020
Publisher: Springer International Publishing
Keyword: Cerebral Small Vessel Disease
Published in: Neurological Sciences / Issue 6/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-04203-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Decreased visible deep medullary veins is a novel imaging marker for cerebral small vessel disease

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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