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Journal of Neurology
Published in: Journal of Neurology 10/2019

01-10-2019 | Review

Cerebral small vessel disease: neuroimaging markers and clinical implication

Authors: Xiaodong Chen, Jihui Wang, Yilong Shan, Wei Cai, Sanxin Liu, Mengyan Hu, Siyuan Liao, Xuehong Huang, Bingjun Zhang, Yuge Wang, Zhengqi Lu

Published in: Journal of Neurology | Issue 10/2019

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Abstract

Cerebral small vessel disease (CSVD) is a broad category of cerebrovascular diseases which primarily affect the perforating arterioles, capillaries and venules with multiple distinct etiologies. In spite of distinctive pathogenesis, CSVD shares similar neuroimaging markers, including recent small subcortical infarct, lacune of presumed vascular origin, white matter hyperintensity of presumed vascular origin, perivascular space and cerebral microbleeds. The radiological features of neuroimaging markers are indicative for etiological analysis. Furthermore, in sporadic arteriosclerotic pathogenesis associated CSVD, the total CSVD burden is a significant predictor for stroke events, global cognitive impairment, psychiatric disorders and later life quality. This review aims to summarize the radiological characteristics as well as the clinical implication of CSVD markers and neuroimaging interpretation for CSVD symptomatology.
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Metadata
Title
Cerebral small vessel disease: neuroimaging markers and clinical implication
Authors
Xiaodong Chen
Jihui Wang
Yilong Shan
Wei Cai
Sanxin Liu
Mengyan Hu
Siyuan Liao
Xuehong Huang
Bingjun Zhang
Yuge Wang
Zhengqi Lu
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 10/2019
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-018-9077-3

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