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Neurological Sciences
Published in: Neurological Sciences 6/2020

01-06-2020 | Stroke | Original Article

Insulin resistance is an independent risk factor for early neurological deterioration in non-diabetic patients with acute ischemic stroke

Authors: Donghua Mi, Yilong Wang, Yongjun Wang, Liping Liu

Published in: Neurological Sciences | Issue 6/2020

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Abstract

Background

The role of insulin resistance (IR) in stroke prognosis remains largely unknown. This study aimed to investigate the relationship between IR and the risk of early neurological deterioration (END) in non-diabetic patients with acute ischemic stroke.

Methods

This is a retrospective analysis of non-diabetic patients with acute ischemic stroke enrolled in the prospective multicenter ACROSS-China study. The homeostasis model assessment 2 (HOMA2-IR) was evaluated and the patients were divided into HOMA2-IR quartiles (Q1 0–1.24, Q2 1.25–1.95, Q3 1.96–2.96, Q4 ≥ 2.97). END was defined as an increment in total National Institutes of Health Stroke Scale (NIHSS) of ≥ 2 points or ≥ 4 points on day 14 ± 3 after stroke onset. Logistic regression was performed to explore the relationship between HOMA2-IR and END.

Results

Finally, 556 patients were included (63.7 ± 12.9 years, 64.6% male); thirty-three patients developed END. The median HOMA2-IR of all patients was 1.95 (inter-quartile = 1.24–2.96). There were 148, 135, 130, and 143 patients in Q1, Q2, Q3, and Q4, respectively. Compared with Q1, END (NIHSS ≥ 2) risk was increased in Q4: adjusted odds ratio (OR) = 6.051, 95% CI = 1.638–22.354, P = 0.0069. In additon, END (NIHSS ≥ 2) risk was increased in Q4 compared with the Q1–Q3 combined group: adjusted OR = 2.853, 95% CI = 1.308–6.224, P = 0.0084. END (NIHSS ≥ 4) risk was also increased in Q4: adjusted OR = 7.507, 95% CI = 2.357–23.906, P = 0.0006) compared with the Q1–Q3 combined group.

Conclusion

This study strongly suggests that IR is probably an independent risk factor for END in non-diabetic patients with acute ischemic stroke.
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Metadata
Title
Insulin resistance is an independent risk factor for early neurological deterioration in non-diabetic patients with acute ischemic stroke
Authors
Donghua Mi
Yilong Wang
Yongjun Wang
Liping Liu
Publication date
01-06-2020
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 6/2020
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-019-04221-7

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