Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Hernia
Published in: Hernia 6/2010

01-12-2010 | Original Article

Shrinkage of intraperitoneal onlay mesh in sheep: coated polyester mesh versus covered polypropylene mesh

Authors: N. B. Zinther, P. Wara, H. Friis-Andersen

Published in: Hernia | Issue 6/2010

Login to get access

Abstract

Background

Currently, the laparoscopic placement of intraperitoneal mesh constitutes an acceptable option in the management of ventral hernia. To date, relatively little has been published on the consequences of intra-abdominal placement of a mesh with respect to the decrease of mesh size (shrinkage).

Methods

In each of 16 sheep, four meshes (dimensions 10 × 10 cm), two based on polyester and two on polypropylene, were placed laparoscopically on intact peritoneum and fixed with either non-absorbable or absorbable tacks. After 3, 6, 12, and 18 months, four animals, respectively, underwent a new laparoscopy with the harvesting of mesh and fascia. Quantitative measurement of the mesh size was performed and expressed as percentage shrinkage. Random core biopsies of mesh and adjacent tissue were obtained and histologically examined.

Results

There was a significant difference of the two meshes with respect to shrinkage at all time points. The coated polyester-based mesh was exposed to more shrinkage compared to the polypropylene mesh covered with anti-adhesive material. Random biopsies at 3 months showed an increased foreign body reaction to the coated polyester mesh.

Conclusions

This study is the first long-term experimental study on mesh shrinkage after the laparoscopic placement of mesh. The polyester-based mesh induced a more intense foreign body reaction and was exposed to significantly more shrinkage than the covered polypropylene mesh.
Literature
1.
Heniford BT, Park A, Ramshaw BJ, Voeller G (2003) Laparoscopic repair of ventral hernias: nine years’ experience with 850 consecutive hernias. Ann Surg 238:391–399PubMed
2.
Sánchez LJ, Bencini L, Moretti R (2004) Recurrences after laparoscopic ventral hernia repair: results and critical review. Hernia 8:138–143CrossRefPubMed
3.
Sains PS, Tilney HS, Purkayastha S, Darzi AW, Athanasiou T, Tekkis PP, Heriot AG (2006) Outcomes following laparoscopic versus open repair of incisional hernia. World J Surg 30:2056–2064CrossRefPubMed
4.
LeBlanc KA, Whitaker JM, Bellanger DE, Rhynes VK (2003) Laparoscopic incisional and ventral hernioplasty: lessons learned from 200 patients. Hernia 7:118–124CrossRefPubMed
5.
Morales-Conde S, Cadet H, Cano A, Bustos M, Martín J, Morales-Mendez S (2005) Laparoscopic ventral hernia repair without sutures—double crown technique: our experience after 140 cases with a mean follow-up of 40 months. Int Surg 90:S56–S62PubMed
6.
Klinge U, Klosterhalfen B, Müller M, Ottinger AP, Schumpelick V (1998) Shrinking of polypropylene mesh in vivo: an experimental study in dogs. Eur J Surg 164:965–969CrossRefPubMed
7.
Klinge U, Klosterhalfen B, Birkenhauer V, Junge K, Conze J, Schumpelick V (2002) Impact of polymer pore size on the interface scar formation in a rat model. J Surg Res 103:208–214CrossRefPubMed
8.
Harrell AG, Novitsky YW, Peindl RD, Cobb WS, Austin CE, Cristiano JA, Norton JH, Kercher KW, Heniford BT (2006) Prospective evaluation of adhesion formation and shrinkage of intra-abdominal prosthetics in a rabbit model. Am Surg 72:808–813PubMed
9.
Schug-Pass C, Tamme C, Sommerer F, Tannapfel A, Lippert H, Köckerling F (2008) A lightweight, partially absorbable mesh (Ultrapro) for endoscopic hernia repair: experimental biocompatibility results obtained with a porcine model. Surg Endosc 22:1100–1106CrossRefPubMed
10.
Schug-Pass C, Sommerer F, Tannapfel A, Lippert H, Köckerling F (2009) The use of composite meshes in laparoscopic repair of abdominal wall hernias: are there differences in biocompatibily?: experimental results obtained in a laparoscopic porcine model. Surg Endosc 23:487–495CrossRefPubMed
11.
Zinther NB, Wara P, Friis-Andersen H (2010) Intraperitoneal onlay mesh: an experimental study of adhesion formation in a sheep model. Hernia (in press). doi:10.​1007/​s10029-009-0622-y
12.
Moll HD, Wolfe DF, Schumacher J, Wright JC (1992) Evaluation of sodium carboxymethylcellulose for prevention of adhesions after uterine trauma in ewes. Am J Vet Res 53:1454–1456PubMed
13.
Ewoldt JM, Anderson DE, Hardy J, Weisbrode SE (2004) Evaluation of a sheep laparoscopic uterine trauma model and repeat laparoscopy for evaluation of adhesion formation and prevention with sodium carboxymethylcellulose. Vet Surg 33:668–672CrossRefPubMed
14.
McGinty JJ, Hogle NJ, McCarthy H, Fowler DL (2005) A comparative study of adhesion formation and abdominal wall ingrowth after laparoscopic ventral hernia repair in a porcine model using multiple types of mesh. Surg Endosc 19:786–790CrossRefPubMed
15.
Conze J, Krones CJ, Schumpelick V, Klinge U (2007) Incisional hernia: challenge of re-operations after mesh repair. Langenbecks Arch Surg 392:453–457CrossRefPubMed
16.
Burger JW, Halm JA, Wijsmuller AR, ten Raa S, Jeekel J (2006) Evaluation of new prosthetic meshes for ventral hernia repair. Surg Endosc 20:1320–1325CrossRefPubMed
17.
Harrell AG, Novitsky YW, Cristiano JA, Gersin KS, Norton HJ, Kercher KW, Heniford BT (2007) Prospective histologic evaluation of intra-abdominal prosthetics four months after implantation in a rabbit model. Surg Endosc 21:1170–1174CrossRefPubMed
18.
Conze J, Junge K, Weiss C, Anurov M, Oettinger A, Klinge U, Schumpelick V (2008) New polymer for intra-abdominal meshes—PVDF copolymer. J Biomed Mater Res B Appl Biomater 87:321–328PubMed
Metadata
Title
Shrinkage of intraperitoneal onlay mesh in sheep: coated polyester mesh versus covered polypropylene mesh
Authors
N. B. Zinther
P. Wara
H. Friis-Andersen
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
Hernia / Issue 6/2010
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI
https://doi.org/10.1007/s10029-010-0682-z

Other articles of this Issue 6/2010

Hernia 6/2010 Go to the issue

Letter to the Editor

Letter to the Editor: “Incidence of contralateral occult inguinal hernia found at the time of laparoscopic trans-abdominal pre-peritoneal (TAPP) repair” by Griffin et al. (Hernia 14:345–349, 2010)

Original Article

Can infected composite mesh be salvaged?

Original Article

Different methods of mesh fixation in open retromuscular incisional hernia repair: a comparative study in pigs

Original Article

Pseudo-recurrence following laparoscopic ventral and incisional hernia repair

Original Article

Advantages of new materials in fascia transversalis reinforcement for inguinal hernia repair

Letter to the Editor

Reply to the letter: “Histology of the internal inguinal ring: it is really a novelty?” by Barria et al. Hernia (2010) 14:339–340