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Published in:

01-06-2010 | Original Article

Intraperitoneal onlay mesh: an experimental study of adhesion formation in a sheep model

Authors: N. B. Zinther, P. Wara, H. Friis-Andersen

Published in: Hernia | Issue 3/2010

Abstract

Purpose

Current hernia literature shows that the use of mesh in ventral hernia repair reduces the risk of recurrence significantly. In laparoscopic repair, the mesh is placed intraperitoneally. Accordingly, the close contact between mesh and viscera involves a risk of adhesion formation. In this experimental study, we examined the degree of de novo adhesion formation over time to currently available meshes.

Methods

Sixteen sheep each received laparoscopic placement of four (10 × 10 cm) meshes on intact peritoneum. Two different mesh materials (coated vs. non-coated) and two different fixation devices (absorbable/non-absorbable) were investigated. (Parietex^®Composite, DynaMesh^®IPOM, ProTack™ and AbsorbaTack™). After 3, 6, 12 and 18 months, four animals, respectively, underwent a new laparoscopy to determine the extent of adhesions to the mesh.

Results

Parietex^®Composite significantly reduced the formation of intraabdominal adhesions compared to DynaMesh^®IPOM. The mean extent of adhesions increases over time without reaching a steady state within the first 12 months after laparoscopic placement.

Conclusions

This is the first long-term (18 months) experimental study on adhesion formation in sheep after laparoscopic placement of mesh and may serve as a template for future studies on meshes before marketing.

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Title: Intraperitoneal onlay mesh: an experimental study of adhesion formation in a sheep model
Authors: N. B. Zinther
P. Wara
H. Friis-Andersen
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Hernia / Issue 3/2010
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI: https://doi.org/10.1007/s10029-009-0622-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intraperitoneal onlay mesh: an experimental study of adhesion formation in a sheep model

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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