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Medical Microbiology and Immunology
Published in: Medical Microbiology and Immunology 2/2009

01-05-2009 | Mini Review

Oncomodulation by human cytomegalovirus: evidence becomes stronger

Authors: Martin Michaelis, Hans Wilhelm Doerr, Jindrich Cinatl Jr

Published in: Medical Microbiology and Immunology | Issue 2/2009

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Excerpt

The human cytomegalovirus (HCMV), a ubiquitous herpes virus, establishes after (in healthy individuals typically subclinical) primary infection a lifelong persistence characterised by more or less frequent subclinical reactivations. It is an important pathogen in immunocompromised individuals and currently investigated for a plethora of different questions and aspects [1‐25]. The (possible) relationship between HCMV and cancer has been discussed for decades [1]. Detection of viral DNA, mRNA and/or antigens in tumour tissues as well as seroepidemiologic evidence suggested a role of HCMV infection in several human malignancies. However, controversial clinical results from different groups had raised skepticism about a role of HCMV in cancer [1]. …
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Metadata
Title
Oncomodulation by human cytomegalovirus: evidence becomes stronger
Authors
Martin Michaelis
Hans Wilhelm Doerr
Jindrich Cinatl Jr
Publication date
01-05-2009
Publisher
Springer-Verlag
Published in
Medical Microbiology and Immunology / Issue 2/2009
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI
https://doi.org/10.1007/s00430-009-0107-8

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