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01-05-2009 | Review

Buruli ulcer disease: prospects for a vaccine

Authors: Kris Huygen, Ohene Adjei, Dissou Affolabi, Gisela Bretzel, Caroline Demangel, Bernhard Fleischer, Roch Christian Johnson, Jorge Pedrosa, Delphin M. Phanzu, Richard O. Phillips, Gerd Pluschke, Vera Siegmund, Mahavir Singh, Tjip S. van der Werf, Mark Wansbrough-Jones, Françoise Portaels

Published in: Medical Microbiology and Immunology | Issue 2/2009

Abstract

Buruli ulcer disease (BUD), caused by Mycobacterium ulcerans, is a neglected bacterial infection of the poor in remote rural areas, mostly affecting children. BUD is a mutilating disease leading to severe disability; it is the third most common mycobacterial infection in immunocompetent people after tuberculosis and leprosy. It is most endemic in West Africa, but cases have been reported from more than 30 countries. Treatment with antibiotics is possible, long-lasting and requires injections; there are cases of treatment failures, and the disease is prone to resistance. A vaccine against M. ulcerans would protect persons at risk in highly endemic areas, and could be used as a therapeutic vaccine to shorten the duration of treatment and prevent relapses. There is considerable evidence supporting the notion that generation of a vaccine is feasible. This article reviews the present state of the art with special emphasis on the immunology of the infection and the prospects for development of a vaccine.

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Title: Buruli ulcer disease: prospects for a vaccine
Authors: Kris Huygen
Ohene Adjei
Dissou Affolabi
Gisela Bretzel
Caroline Demangel
Bernhard Fleischer
Roch Christian Johnson
Jorge Pedrosa
Delphin M. Phanzu
Richard O. Phillips
Gerd Pluschke
Vera Siegmund
Mahavir Singh
Tjip S. van der Werf
Mark Wansbrough-Jones
Françoise Portaels
Publication date: 01-05-2009
Publisher: Springer-Verlag
Published in: Medical Microbiology and Immunology / Issue 2/2009
Print ISSN: 0300-8584
Electronic ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-009-0109-6

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