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01-02-2021 | Affective Disorder | Original Contribution

The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project

Authors: Arpita Das, Robert G. Cumming, Vasi Naganathan, Rosilene V. Ribeiro, David G. Le Couteur, David J. Handelsman, Louise M. Waite, Vasant Hirani

Published in: European Journal of Nutrition | Issue 1/2021

Abstract

Purpose

The objectives of the study were to evaluate the associations between antioxidant intake, dietary patterns and depressive symptoms among older men.

Method

794 men participated in a detailed diet history interview at the Concord Health and Ageing in Men Project 3rd wave (considered baseline nutrition) and 781 men participated at the 4th wave (considered 3-year follow-up). Depressive symptoms were measured using the Geriatric Depression Scale (GDS ≥ 5). Dietary adequacy of antioxidant intake was assessed by comparing participants' median intake of vitamin A, E, C and zinc to the Nutrient Reference Values for Australia. Attainment of NRVs of antioxidant was categorised into a dichotomised variable 'poor' (meeting ≤ 2) or 'good' (meeting ≥ 3). Individual antioxidant nutrient was categorised into quartiles. The Australian and Mediterranean diet scores were assessed as predictor variables.

Results

The prevalence of GDS ≥ 5 was 12.8% at baseline nutrition and 13.2% of men developed GDS ≥ 5 at a 3-year follow-up. There was a significant cross-sectional association between poor antioxidant intake and GDS ≥ 5 in adjusted analyses [OR: 1.95 (95% CI 1.03, 3.70)]. Poor antioxidant intake at baseline nutrition remained prospectively associated with incident GDS ≥ 5 [OR: 2.46 (95% CI 1.24, 4.88)] in adjusted analyses. This association was also found for the lowest quartile of zinc [OR 2.72 (95% CI 1.37, 5.42)] and vitamin E intake [OR 2.18 (95% CI 1.05, 4.51)]. None of the other antioxidants and dietary patterns had a significant association with incident depressive symptoms.

Conclusion

Inadequacy of antioxidant intake, particularly zinc and vitamin E, is associated with increased risk of clinically significant depressive symptoms in older men.

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Title: The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project
Authors: Arpita Das
Robert G. Cumming
Vasi Naganathan
Rosilene V. Ribeiro
David G. Le Couteur
David J. Handelsman
Louise M. Waite
Vasant Hirani
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Affective Disorder
Nutrition
Affective Disorder
Published in: European Journal of Nutrition / Issue 1/2021
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-020-02255-8

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