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Published in: European Journal of Nutrition 2/2014

01-03-2014 | Original Contribution

Calcium co-ingestion augments postprandial glucose-dependent insulinotropic peptide1–42, glucagon-like peptide-1 and insulin concentrations in humans

Authors: Javier T. Gonzalez, Emma J. Stevenson

Published in: European Journal of Nutrition | Issue 2/2014

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Abstract

Purpose

This study determined whether calcium co-ingestion potentiates postprandial GIP1–42 and GLP-1 concentrations in humans and the concomitant impact on insulin, appetite sensations and substrate metabolism.

Methods

Ten healthy males consumed two energy- and macronutrient-matched meals in a double-blind, randomized, crossover design. The calcium content of the control meal was 3 mg/kg body mass, which was increased to 15 mg/kg body mass with calcium co-ingestion. Circulating concentrations of GIP1–42, GLP-1 and insulin were determined over a 180-min postprandial period, followed by 60 min of exercise. Visual analogue scales were used to determine subjective appetite sensations. Rates of energy expenditure and substrate (lipid and carbohydrate) oxidation were estimated using indirect calorimetry.

Results

Calcium co-ingestion resulted in a 47 % increase in GIP1–42, a 22 % increase in GLP-1 and a 19 % increase in insulin areas under the curve for the 120 min following consumption (all P < 0.05). Furthermore, appetite sensations were suppressed by calcium co-ingestion by 12 % (P = 0.034). No differences, however, were observed in substrate metabolism (P > 0.05).

Conclusion

Ingestion of a high-calcium meal potentiates postprandial GIP1–42, GLP-1 and insulin concentrations in humans. Subjective appetite is also temporarily suppressed, although substrate metabolism is unaffected.
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Metadata
Title
Calcium co-ingestion augments postprandial glucose-dependent insulinotropic peptide1–42, glucagon-like peptide-1 and insulin concentrations in humans
Authors
Javier T. Gonzalez
Emma J. Stevenson
Publication date
01-03-2014
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 2/2014
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-013-0532-8

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