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European Journal of Nutrition
Published in: European Journal of Nutrition 2/2014

01-03-2014 | Original Contribution

The combination of resveratrol and conjugated linoleic acid attenuates the individual effects of these molecules on triacylglycerol metabolism in adipose tissue

Authors: N. Arias, J. Miranda, M. T. Macarulla, L. Aguirre, A. Fernández-Quintela, C. Andres-Lacueva, M. Urpi-Sarda, M. P. Portillo

Published in: European Journal of Nutrition | Issue 2/2014

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Abstract

Purpose

The combination of resveratrol + conjugated linoleic acid (RSV + CLA) did not show the body fat-lowering effect exhibited by these molecules when administered separately. This study aimed to find metabolic explanations for this situation in an experimental model of diet-induced obesity.

Methods

Thirty-six male Wistar rats were divided into four groups: rats treated with saline (control), resveratrol (RSV), conjugated linoleic acid (CLA) and a combination of these molecules (RSV + CLA).

Results

Rats treated with RSV + CLA did not show the reduction in heparin-releasable lipoprotein lipase (HR-LPL) and fatty acid synthase activities observed in RSV group or the increased HSL expression found in RSV and CLA groups. These animals showed reduced sirtuin 1 expression and CLA isomer amounts in adipose tissue. Finally, intracellular Ca2+ concentration was increased.

Conclusion

The attenuation of the effects induced in adipose tissue triacylglycerol metabolism by RSV and CLA separately, such as the decrease in lipogenesis and fatty acid uptake and the increase in lipolysis, contributes to explain the lack of body fat-lowering effect of the combination RSV + CLA.
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Metadata
Title
The combination of resveratrol and conjugated linoleic acid attenuates the individual effects of these molecules on triacylglycerol metabolism in adipose tissue
Authors
N. Arias
J. Miranda
M. T. Macarulla
L. Aguirre
A. Fernández-Quintela
C. Andres-Lacueva
M. Urpi-Sarda
M. P. Portillo
Publication date
01-03-2014
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 2/2014
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-013-0566-y

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