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Published in: Clinical Research in Cardiology 4/2021

Open Access 01-04-2021 | Heart Failure | Review

Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside

Authors: Márta Sárközy, Zoltán Varga, Renáta Gáspár, Gergő Szűcs, Mónika G. Kovács, Zsuzsanna Z. A. Kovács, László Dux, Zsuzsanna Kahán, Tamás Csont

Published in: Clinical Research in Cardiology | Issue 4/2021

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Abstract

Cancer management has undergone significant improvements, which led to increased long-term survival rates among cancer patients. Radiotherapy (RT) has an important role in the treatment of thoracic tumors, including breast, lung, and esophageal cancer, or Hodgkin's lymphoma. RT aims to kill tumor cells; however, it may have deleterious side effects on the surrounding normal tissues. The syndrome of unwanted cardiovascular adverse effects of thoracic RT is termed radiation-induced heart disease (RIHD), and the risk of developing RIHD is a critical concern in current oncology practice. Premature ischemic heart disease, cardiomyopathy, heart failure, valve abnormalities, and electrical conduct defects are common forms of RIHD. The underlying mechanisms of RIHD are still not entirely clear, and specific therapeutic interventions are missing. In this review, we focus on the molecular pathomechanisms of acute and chronic RIHD and propose preventive measures and possible pharmacological strategies to minimize the burden of RIHD.
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Metadata
Title
Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside
Authors
Márta Sárközy
Zoltán Varga
Renáta Gáspár
Gergő Szűcs
Mónika G. Kovács
Zsuzsanna Z. A. Kovács
László Dux
Zsuzsanna Kahán
Tamás Csont
Publication date
01-04-2021
Publisher
Springer Berlin Heidelberg
Published in
Clinical Research in Cardiology / Issue 4/2021
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-021-01809-y

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