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Radiation Oncology
Published in: Radiation Oncology 1/2017

Open Access 01-12-2017 | Review

Influence of autophagy on the efficacy of radiotherapy

Authors: Shing Yau Tam, Vincent Wing Cheung Wu, Helen Ka Wai Law

Published in: Radiation Oncology | Issue 1/2017

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Abstract

Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.

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Metadata
Title
Influence of autophagy on the efficacy of radiotherapy
Authors
Shing Yau Tam
Vincent Wing Cheung Wu
Helen Ka Wai Law
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2017
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-017-0795-y

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