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Child's Nervous System

Published in:

01-07-2017 | Review Paper

Hydrocephalus and mucopolysaccharidoses: what do we know and what do we not know?

Authors: Amauri Dalla Corte, Carolina F. M. de Souza, Maurício Anés, Roberto Giugliani

Published in: Child's Nervous System | Issue 7/2017

Abstract

Introduction

The precise incidence of hydrocephalus in patients with mucopolysaccharidoses (MPS) is hard to determine, because the condition lacks a formal, consensus-based definition. The diagnosis of hydrocephalus depends on symptom profile, presence of neuroimaging features, and the outcome of diagnostic tests. Although numerous techniques are used to identify MPS patients who are most likely to have hydrocephalus and respond to treatment, no definitive method exists to prove diagnosis.

Purpose

The authors propose an algorithm to aid in the diagnosis and management of hydrocephalus in MPS patients.

Conclusions

The theory of venous hypertension associated with the morphological changes in the skull base and craniocervical junction indicate the need for future neuroimaging studies including cerebrospinal fluid (CSF) and venous flow measurements to monitor hydrocephalus progression and select therapeutic interventions in MPS patients. Preoperative planning should also be based on the increased risk of intraoperative and postoperative hemorrhagic complications.

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Title: Hydrocephalus and mucopolysaccharidoses: what do we know and what do we not know?
Authors: Amauri Dalla Corte
Carolina F. M. de Souza
Maurício Anés
Roberto Giugliani
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 7/2017
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-017-3476-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Hydrocephalus and mucopolysaccharidoses: what do we know and what do we not know?

Abstract

Introduction

Purpose

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Purpose

Conclusions

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