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European Radiology

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01-11-2017 | Nuclear Medicine

The impact of image reconstruction settings on 18F-FDG PET radiomic features: multi-scanner phantom and patient studies

Authors: Isaac Shiri, Arman Rahmim, Pardis Ghaffarian, Parham Geramifar, Hamid Abdollahi, Ahmad Bitarafan-Rajabi

Published in: European Radiology | Issue 11/2017

Abstract

Objectives

The purpose of this study was to investigate the robustness of different PET/CT image radiomic features over a wide range of different reconstruction settings.

Methods

Phantom and patient studies were conducted, including two PET/CT scanners. Different reconstruction algorithms and parameters including number of sub-iterations, number of subsets, full width at half maximum (FWHM) of Gaussian filter, scan time per bed position and matrix size were studied. Lesions were delineated and one hundred radiomic features were extracted. All radiomics features were categorized based on coefficient of variation (COV).

Results

Forty seven percent features showed COV ≤ 5% and 10% of which showed COV > 20%. All geometry based, 44% and 41% of intensity based and texture based features were found as robust respectively. In regard to matrix size, 56% and 6% of all features were found non-robust (COV > 20%) and robust (COV ≤ 5%) respectively.

Conclusions

Variability and robustness of PET/CT image radiomics in advanced reconstruction settings is feature-dependent, and different settings have different effects on different features. Radiomic features with low COV can be considered as good candidates for reproducible tumour quantification in multi-center studies.

Key Points

• PET/CT image radiomics is a quantitative approach assessing different aspects of tumour uptake.

• Radiomic features robustness is an important issue over different image reconstruction settings.

• Variability and robustness of PET/CT image radiomics in advanced reconstruction settings is feature-dependent.

• Robust radiomic features can be considered as good candidates for tumour quantification

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Title: The impact of image reconstruction settings on 18F-FDG PET radiomic features: multi-scanner phantom and patient studies
Authors: Isaac Shiri
Arman Rahmim
Pardis Ghaffarian
Parham Geramifar
Hamid Abdollahi
Ahmad Bitarafan-Rajabi
Publication date: 01-11-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 11/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-4859-z

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The impact of image reconstruction settings on 18F-FDG PET radiomic features: multi-scanner phantom and patient studies

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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