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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 5/2016

Open Access 01-10-2016 | Research Article

Repeatability of Radiomic Features in Non-Small-Cell Lung Cancer [18F]FDG-PET/CT Studies: Impact of Reconstruction and Delineation

Authors: Floris H. P. van Velden, Gerbrand M. Kramer, Virginie Frings, Ida A. Nissen, Emma R. Mulder, Adrianus J. de Langen, Otto S. Hoekstra, Egbert F. Smit, Ronald Boellaard

Published in: Molecular Imaging and Biology | Issue 5/2016

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Abstract

Purpose

To assess (1) the repeatability and (2) the impact of reconstruction methods and delineation on the repeatability of 105 radiomic features in non-small-cell lung cancer (NSCLC) 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomorgraphy/computed tomography (PET/CT) studies.

Procedures

Eleven NSCLC patients received two baseline whole-body PET/CT scans. Each scan was reconstructed twice, once using the point spread function (PSF) and once complying with the European Association for Nuclear Medicine (EANM) guidelines for tumor PET imaging. Volumes of interest (n = 19) were delineated twice, once on PET and once on CT images.

Results

Sixty-three features showed an intraclass correlation coefficient ≥ 0.90 independent of delineation or reconstruction. More features were sensitive to a change in delineation than to a change in reconstruction (25 and 3 features, respectively).

Conclusions

The majority of features in NSCLC [18F]FDG-PET/CT studies show a high level of repeatability that is similar or better compared to simple standardized uptake value measures.
Appendix
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Metadata
Title
Repeatability of Radiomic Features in Non-Small-Cell Lung Cancer [18F]FDG-PET/CT Studies: Impact of Reconstruction and Delineation
Authors
Floris H. P. van Velden
Gerbrand M. Kramer
Virginie Frings
Ida A. Nissen
Emma R. Mulder
Adrianus J. de Langen
Otto S. Hoekstra
Egbert F. Smit
Ronald Boellaard
Publication date
01-10-2016
Publisher
Springer US
Published in
Molecular Imaging and Biology / Issue 5/2016
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-016-0940-2

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