Skip to main content
Top
Published in: European Radiology 6/2016

01-06-2016 | Musculoskeletal

Subchondral insufficiency fractures of the femoral head: associated imaging findings and predictors of clinical progression

Authors: Lauren A. Hackney, Min Hee Lee, Gabby B. Joseph, Thomas P. Vail, Thomas M. Link

Published in: European Radiology | Issue 6/2016

Login to get access

Abstract

Objectives

To characterize the morphology and imaging findings of femoral head subchondral insufficiency fractures (SIF), and to investigate clinical outcomes in relation to imaging findings.

Methods

Fifty-one patients with hip/pelvis magnetic resonance (MR) images and typical SIF characteristics were identified and reviewed by two radiologists. Thirty-five patients had follow-up documentation allowing assessment of clinical outcome. Subgroup comparisons were performed using regression models adjusted for age and body mass index.

Results

SIF were frequently associated with cartilage loss (35/47, 74.5 %), effusion (33/42, 78.6 %), synovitis (29/44, 66 %), and bone marrow oedema pattern (BMEP) (average cross-sectional area 885.7 ± 730.2 mm2). Total hip arthroplasty (THA) was required in 16/35 patients, at an average of 6 months post-MRI. Compared to the THA cohort, the non-THA group had significantly (p < 0.05) smaller overlying cartilage defect size (10 mm vs. 29 mm), smaller band length ratio and fracture diameters, and greater incidence of parallel fracture morphology (p < 0.05). Male gender and increased age were significantly associated with progression, p < 0.05.

Conclusions

SIF were associated with synovitis, cartilage loss, effusion, and BMEP. Male gender and increased age had a significant association with progression to THA, as did band length ratio, fracture diameter, cartilage defect size, and fracture deformity/morphology.

Key points

Femoral head subchondral insufficiency fractures (SIF) frequently require total hip arthroplasty (THA).
SIF frequently coexist with synovitis, cartilage loss, and bone marrow oedema pattern.
SIF cartilage defect size, band length ratio, and fracture diameter/morphology can predict progression risk.
Literature
1.
go back to reference Bangil M, Soubrier M, Dubost JJ et al (1996) Subchondral insufficiency fracture of the femoral head. Rev Rhum Engl Ed 63:859–861PubMed Bangil M, Soubrier M, Dubost JJ et al (1996) Subchondral insufficiency fracture of the femoral head. Rev Rhum Engl Ed 63:859–861PubMed
2.
go back to reference Iwasaki K, Yamamoto T, Motomura G, Mawatari T, Nakashima Y, Iwamoto Y (2011) Subchondral insufficiency fracture of the femoral head in young adults. Clin Imaging 35:208–213CrossRefPubMed Iwasaki K, Yamamoto T, Motomura G, Mawatari T, Nakashima Y, Iwamoto Y (2011) Subchondral insufficiency fracture of the femoral head in young adults. Clin Imaging 35:208–213CrossRefPubMed
3.
go back to reference Yamamoto T, Nakashima Y, Shuto T, Jingushi S, Iwamoto Y (2007) Subchondral insufficiency fracture of the femoral head in younger adults. Skelet Radiol 36:S38–S42CrossRef Yamamoto T, Nakashima Y, Shuto T, Jingushi S, Iwamoto Y (2007) Subchondral insufficiency fracture of the femoral head in younger adults. Skelet Radiol 36:S38–S42CrossRef
4.
go back to reference Yoon PW, Kwak HS, Yoo JJ, Yoon KS, Kim HJ (2014) Subchondral insufficiency fracture of the femoral head in elderly people. J Korean Med Sci 29:593–598CrossRefPubMedPubMedCentral Yoon PW, Kwak HS, Yoo JJ, Yoon KS, Kim HJ (2014) Subchondral insufficiency fracture of the femoral head in elderly people. J Korean Med Sci 29:593–598CrossRefPubMedPubMedCentral
5.
go back to reference Uetani M, Hashmi R, Ito M et al (2003) Subchondral insufficiency fracture of the femoral head: magnetic resonance imaging findings correlated with micro-computed tomography and histopathology. J Comput Assist Tomogr 27:189–193CrossRefPubMed Uetani M, Hashmi R, Ito M et al (2003) Subchondral insufficiency fracture of the femoral head: magnetic resonance imaging findings correlated with micro-computed tomography and histopathology. J Comput Assist Tomogr 27:189–193CrossRefPubMed
6.
go back to reference Zhao G, Yamamoto T, Ikemura S et al (2010) A histopathological evaluation of a concave-shaped low-intensity band on T1-weighted MR images in a subchondral insufficiency fracture of the femoral head. Skelet Radiol 39:185–188CrossRef Zhao G, Yamamoto T, Ikemura S et al (2010) A histopathological evaluation of a concave-shaped low-intensity band on T1-weighted MR images in a subchondral insufficiency fracture of the femoral head. Skelet Radiol 39:185–188CrossRef
7.
go back to reference Yamamoto T, Iwamoto Y, Schneider R, Bullough PG (2008) Histopathological prevalence of subchondral insufficiency fracture of the femoral head. Ann Rheum Dis 67:150–153CrossRefPubMed Yamamoto T, Iwamoto Y, Schneider R, Bullough PG (2008) Histopathological prevalence of subchondral insufficiency fracture of the femoral head. Ann Rheum Dis 67:150–153CrossRefPubMed
8.
go back to reference Yamamoto T, Bullough PG (1999) Subchondral insufficiency fracture of the femoral head: a differential diagnosis in acute onset of coxarthrosis in the elderly. Arthritis Rheum 42:2719–2723CrossRefPubMed Yamamoto T, Bullough PG (1999) Subchondral insufficiency fracture of the femoral head: a differential diagnosis in acute onset of coxarthrosis in the elderly. Arthritis Rheum 42:2719–2723CrossRefPubMed
9.
go back to reference Yamamoto T, Schneider R, Bullough PG (2001) Subchondral insufficiency fracture of the femoral head: histopathologic correlation with MRI. Skelet Radiol 30:247–254CrossRef Yamamoto T, Schneider R, Bullough PG (2001) Subchondral insufficiency fracture of the femoral head: histopathologic correlation with MRI. Skelet Radiol 30:247–254CrossRef
10.
go back to reference Davies M, Cassar-Pullicino VN, Darby AJ (2004) Subchondral insufficiency fractures of the femoral head. Eur Radiol 14:201–207CrossRefPubMed Davies M, Cassar-Pullicino VN, Darby AJ (2004) Subchondral insufficiency fractures of the femoral head. Eur Radiol 14:201–207CrossRefPubMed
11.
go back to reference Miyanishi K, Hara T, Kaminomachi S, Maeda H, Watanabe H, Torisu T (2009) Contrast-enhanced MR imaging of subchondral insufficiency fracture of the femoral head: a preliminary comparison with that of osteonecrosis of the femoral head. Arch Orthop Trauma Surg 129:583–589CrossRefPubMed Miyanishi K, Hara T, Kaminomachi S, Maeda H, Watanabe H, Torisu T (2009) Contrast-enhanced MR imaging of subchondral insufficiency fracture of the femoral head: a preliminary comparison with that of osteonecrosis of the femoral head. Arch Orthop Trauma Surg 129:583–589CrossRefPubMed
12.
go back to reference Ikemura S, Yamamoto T, Motomura G, Nakashima Y, Mawatari T, Iwamoto Y (2010) MRI evaluation of collapsed femoral heads in patients 60 years or older: differentiation of subchondral insufficiency fracture from osteonecrosis of the femoral head. AJR Am J Roentgenol 195:63–68CrossRef Ikemura S, Yamamoto T, Motomura G, Nakashima Y, Mawatari T, Iwamoto Y (2010) MRI evaluation of collapsed femoral heads in patients 60 years or older: differentiation of subchondral insufficiency fracture from osteonecrosis of the femoral head. AJR Am J Roentgenol 195:63–68CrossRef
13.
go back to reference Ikemura S, Yamamoto T, Motomura G, Nakashima Y, Mawatari T, Iwamoto Y (2013) The utility of clinical features for distinguishing subchondral insufficiency fracture from osteonecrosis of the femoral head. Arch Orthop Trauma Surg 133:1623–1627CrossRefPubMed Ikemura S, Yamamoto T, Motomura G, Nakashima Y, Mawatari T, Iwamoto Y (2013) The utility of clinical features for distinguishing subchondral insufficiency fracture from osteonecrosis of the femoral head. Arch Orthop Trauma Surg 133:1623–1627CrossRefPubMed
14.
go back to reference Rafii M, Mitnick H, Klug J, Firooznia H (1997) Insufficiency fracture of the femoral head: MR imaging in three patients. AJR Am J Roentgenol 168:159–163CrossRefPubMed Rafii M, Mitnick H, Klug J, Firooznia H (1997) Insufficiency fracture of the femoral head: MR imaging in three patients. AJR Am J Roentgenol 168:159–163CrossRefPubMed
15.
go back to reference Hagino H, Okano T, Teshima R, Nishi T, Yamamoto K (1999) Insufficiency fracture of the femoral head in patients with severe osteoporosis: report of 2 cases. Acta Orthop Scand 70:87–89CrossRefPubMed Hagino H, Okano T, Teshima R, Nishi T, Yamamoto K (1999) Insufficiency fracture of the femoral head in patients with severe osteoporosis: report of 2 cases. Acta Orthop Scand 70:87–89CrossRefPubMed
16.
go back to reference Yamamoto T, Bullough PG (2000) The role of subchondral insufficiency fracture in rapid destruction of the hip joint: a preliminary report. Arthritis Rheum 43:2423–2427CrossRefPubMed Yamamoto T, Bullough PG (2000) The role of subchondral insufficiency fracture in rapid destruction of the hip joint: a preliminary report. Arthritis Rheum 43:2423–2427CrossRefPubMed
17.
go back to reference Fukui K, Kaneuji A, Fukushima M, Matsumoto T (2015) Early MRI and intraoperative findings in rapidly destructive osteoarthritis of the hip: a case report. Int J Surg Case Rep 8:13–17CrossRefPubMedCentral Fukui K, Kaneuji A, Fukushima M, Matsumoto T (2015) Early MRI and intraoperative findings in rapidly destructive osteoarthritis of the hip: a case report. Int J Surg Case Rep 8:13–17CrossRefPubMedCentral
18.
go back to reference Yamamoto T, Takabatake K, Iwamoto Y (2002) Subchondral insufficiency fracture of the femoral head resulting in rapid destruction of the hip joint: a sequential radiographic study. AJR Am J Roentgenol 178:435–437CrossRefPubMed Yamamoto T, Takabatake K, Iwamoto Y (2002) Subchondral insufficiency fracture of the femoral head resulting in rapid destruction of the hip joint: a sequential radiographic study. AJR Am J Roentgenol 178:435–437CrossRefPubMed
19.
go back to reference Iwasaki K, Yamamoto T, Motomura G et al (2012) Prognostic factors associated with a subchondral insufficiency fracture of the femoral head. Br J Radiol 85:214–218CrossRefPubMedPubMedCentral Iwasaki K, Yamamoto T, Motomura G et al (2012) Prognostic factors associated with a subchondral insufficiency fracture of the femoral head. Br J Radiol 85:214–218CrossRefPubMedPubMedCentral
20.
go back to reference Miyanishi K, Ishihara K, Jingushi S, Torisu T (2010) Risk factors leading to total hip arthroplasty in patients with subchondral insufficiency fractures of the femoral head. J Orthop Surg (Hong Kong) 18:271–275 Miyanishi K, Ishihara K, Jingushi S, Torisu T (2010) Risk factors leading to total hip arthroplasty in patients with subchondral insufficiency fractures of the femoral head. J Orthop Surg (Hong Kong) 18:271–275
22.
go back to reference Altman RD, Gold GE (2007) Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthr Cartil 15:A1–A56CrossRefPubMed Altman RD, Gold GE (2007) Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthr Cartil 15:A1–A56CrossRefPubMed
23.
go back to reference Gossec L, Jordan JM, Lam M et al (2009) Comparative evaluation of three semi-quantitative radiographic grading techniques for hip osteoarthritis in terms of validity and reproducibility in 1404 radiographs: report of the OARSI-OMERACT task force. Osteoarthr Cartil 17:182–187CrossRefPubMed Gossec L, Jordan JM, Lam M et al (2009) Comparative evaluation of three semi-quantitative radiographic grading techniques for hip osteoarthritis in terms of validity and reproducibility in 1404 radiographs: report of the OARSI-OMERACT task force. Osteoarthr Cartil 17:182–187CrossRefPubMed
24.
go back to reference Lee S, Nardo L, Kumar D et al (2014) Scoring hip osteoarthritis with MRI (SHOMRI): a whole joint osteoarthritis evaluation system. J Magn Reson Imaging 41:1549–1557CrossRefPubMed Lee S, Nardo L, Kumar D et al (2014) Scoring hip osteoarthritis with MRI (SHOMRI): a whole joint osteoarthritis evaluation system. J Magn Reson Imaging 41:1549–1557CrossRefPubMed
25.
go back to reference Lippe J, Spang JT, Leger RR, Arciero RA, Mazzocca AD, Shea KP (2012) Inter-rater agreement of the Goutallier, Patte, and Warner classification scores using preoperative magnetic resonance imaging in patients with rotator cuff tears. Arthroscopy 28:154–159CrossRefPubMed Lippe J, Spang JT, Leger RR, Arciero RA, Mazzocca AD, Shea KP (2012) Inter-rater agreement of the Goutallier, Patte, and Warner classification scores using preoperative magnetic resonance imaging in patients with rotator cuff tears. Arthroscopy 28:154–159CrossRefPubMed
26.
go back to reference Niimi R, Hasegawa M, Sudo A, Uchida A (2005) Rapidly destructive coxopathy after subchondral insufficiency fracture of the femoral head. Arch Orthop Trauma Surg 125:410–413CrossRefPubMed Niimi R, Hasegawa M, Sudo A, Uchida A (2005) Rapidly destructive coxopathy after subchondral insufficiency fracture of the femoral head. Arch Orthop Trauma Surg 125:410–413CrossRefPubMed
27.
go back to reference Kubo T, Yamazoe S, Sugano N (1997) Initial MRI findings of non-traumatic osteonecrosis of the femoral head in renal allograft recipients. Magn Reson Imaging 15:1017–1023CrossRefPubMed Kubo T, Yamazoe S, Sugano N (1997) Initial MRI findings of non-traumatic osteonecrosis of the femoral head in renal allograft recipients. Magn Reson Imaging 15:1017–1023CrossRefPubMed
28.
go back to reference Vande Berg BC, Malghem JJ, Lecouvet FE, Jamart J, Maldague BE (1999) Idiopathic bone marrow edema lesions of the femoral head: predictive value of MR imaging findings. Radiology 212:527–535CrossRefPubMed Vande Berg BC, Malghem JJ, Lecouvet FE, Jamart J, Maldague BE (1999) Idiopathic bone marrow edema lesions of the femoral head: predictive value of MR imaging findings. Radiology 212:527–535CrossRefPubMed
29.
go back to reference Yamamoto T, Karasuyama K, Iwasaki K, Doi T, Iwamoto Y (2014) Subchondral insufficiency fracture of the femoral head in males. Arch Orthop Trauma Surg 134:1199–1203CrossRefPubMed Yamamoto T, Karasuyama K, Iwasaki K, Doi T, Iwamoto Y (2014) Subchondral insufficiency fracture of the femoral head in males. Arch Orthop Trauma Surg 134:1199–1203CrossRefPubMed
30.
go back to reference Iwasaki K, Yamamoto T, Motomura G, Ikemura S, Yamaguchi R, Iwamoto Y (2013) Radiologic measurements associated with the prognosis and need for surgery in patients with subchondral insufficiency fractures of the femoral head. AJR Am J Roentgenol 201:W97–W103CrossRefPubMed Iwasaki K, Yamamoto T, Motomura G, Ikemura S, Yamaguchi R, Iwamoto Y (2013) Radiologic measurements associated with the prognosis and need for surgery in patients with subchondral insufficiency fractures of the femoral head. AJR Am J Roentgenol 201:W97–W103CrossRefPubMed
31.
go back to reference Bruyere O, Pavelka K, Rovati LC et al (2008) Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials. Osteoarthr Cartil 16:254–260CrossRefPubMed Bruyere O, Pavelka K, Rovati LC et al (2008) Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials. Osteoarthr Cartil 16:254–260CrossRefPubMed
Metadata
Title
Subchondral insufficiency fractures of the femoral head: associated imaging findings and predictors of clinical progression
Authors
Lauren A. Hackney
Min Hee Lee
Gabby B. Joseph
Thomas P. Vail
Thomas M. Link
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3967-x

Other articles of this Issue 6/2016

European Radiology 6/2016 Go to the issue