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European Radiology
Published in: European Radiology 6/2016

01-06-2016 | Musculoskeletal

Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative

Authors: Felix Eckstein, Robert Boudreau, Zhijie Wang, Michael J. Hannon, Jeff Duryea, Wolfgang Wirth, Sebastian Cotofana, Ali Guermazi, Frank Roemer, Michael Nevitt, Markus R. John, Christoph Ladel, Leena Sharma, David J. Hunter, C. Kent Kwoh, for the OAI Investigators

Published in: European Radiology | Issue 6/2016

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Abstract

Objective

To evaluate whether change in fixed-location measures of radiographic joint space width (JSW) and cartilage thickness by MRI predict knee replacement.

Methods

Knees replaced between 36 and 60 months’ follow-up in the Osteoarthritis Initiative were each matched with one control by age, sex and radiographic status. Radiographic JSW was determined from fixed flexion radiographs and subregional femorotibial cartilage thickness from 3 T MRI. Changes between the annual visit before replacement (T0) and 2 years before T0 (T-2) were compared using conditional logistic regression.

Results

One hundred and nineteen knees from 102 participants (55.5 % women; age 64.2 ± 8.7 [mean ± SD] years) were studied. Fixed-location JSW change at 22.5 % from medial to lateral differed more between replaced and control knees (case-control [cc] OR = 1.57; 95 % CI: 1.23–2.01) than minimum medial JSW change (ccOR = 1.38; 95 % CI: 1.11–1.71). Medial femorotibial cartilage loss displayed discrimination similar to minimum JSW, and central tibial cartilage loss similar to fixed-location JSW. Location-independent thinning and thickening scores were elevated prior to knee replacement.

Conclusions

Discrimination of structural progression between knee pre-placement cases versus controls was stronger for fixed-location than minimum radiographic JSW. MRI displayed similar discrimination to radiography and suggested greater simultaneous cartilage thickening and loss prior to knee replacement.

Key Points

• Fixed-location JSW predicts surgical knee replacement more strongly than minimum JSW.
• MRI predicts knee replacement with similar accuracy to radiographic JSW.
• MRI reveals greater cartilage thinning and thickening prior to knee replacement.
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Metadata
Title
Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative
Authors
Felix Eckstein
Robert Boudreau
Zhijie Wang
Michael J. Hannon
Jeff Duryea
Wolfgang Wirth
Sebastian Cotofana
Ali Guermazi
Frank Roemer
Michael Nevitt
Markus R. John
Christoph Ladel
Leena Sharma
David J. Hunter
C. Kent Kwoh
for the OAI Investigators
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3977-8

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