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01-07-2020 | SARS-CoV-2 | Review Article

Hematological findings in coronavirus disease 2019: indications of progression of disease

Authors: Xiaoqing Liu, Run Zhang, Guangsheng He

Published in: Annals of Hematology | Issue 7/2020

Abstract

Coronavirus disease 2019 (COVID-19) is a new human infectious disease. The etiology for this outbreak is a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus far, related research on COVID-19 is still in preliminary stage. This paper summarized the latest outcomes of corresponding study from Chinese centers and clarified the hematopoietic abnormality caused by SARS-CoV-2 and potential mechanism. Lymphopenia was common in the early stage after the onset of COVID-19. A significant decrease was observed in peripheral CD4+ and CD8+ T lymphocytes. As the illness progressed, neutrophilia emerged in several cases, and patients with severe critical pulmonary conditions showed higher neutrophils than common type. Thrombocytopenia was resulting from the consumption and/or the reduced production of platelets in damaged lungs. Anemia was not observed notably, but the decrease in hemoglobin was frequent. The activation of monocyte-macrophage system aggravates the immune damage of lung and other tissues, which leads to the increase of D-dimer, prothrombin time, and platelet consumption.

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Title: Hematological findings in coronavirus disease 2019: indications of progression of disease
Authors: Xiaoqing Liu
Run Zhang
Guangsheng He
Publication date: 01-07-2020
Publisher: Springer Berlin Heidelberg
Keywords: SARS-CoV-2
Lymphopenia
Neutrophilia
Thrombocytopenia
COVID-19
Published in: Annals of Hematology / Issue 7/2020
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-020-04103-5

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