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Abdominal Radiology
Published in: Abdominal Radiology 9/2019

01-09-2019 | Lymphoma | Review

Primary lymphomas of the intraabdominal solid organs and the gastrointestinal tract: spectrum of imaging findings with histopathological confirmation

Authors: Ali Devrim Karaosmanoglu, Aycan Uysal, Mehmet Ruhi Onur, Peter F. Hahn, Arzu Saglam Ayhan, Mustafa Nasuh Ozmen, Deniz Akata, Musturay Karcaaltincaba

Published in: Abdominal Radiology | Issue 9/2019

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Abstract

Unlike nodal lymphoma, primary lymphomas of the intraabdominal organs are uncommon neoplasms whose diagnosis may be challenging in certain clinical circumstances. Despite this difficulty for imaging diagnosis, there are several imaging features on ultrasonography, computed tomography, magnetic resonance imaging, and positron emission tomography that may suggest the correct diagnosis. The scope of this review is to describe and illustrate the imaging features of primary lymphoma of intraabdominal organs providing clues to the diagnosis, together with their pathological correlations.
Literature
1.
Guermazi, A., et al., Extranodal Hodgkin disease: spectrum of disease. Radiographics, 2001. 21(1): p. 161-79.CrossRef
2.
Leite, N.P., et al., Cross-sectional imaging of extranodal involvement in abdominopelvic lymphoproliferative malignancies. Radiographics, 2007. 27(6): p. 1613-34.CrossRefPubMed
3.
4.
Lee, W.K., et al., Abdominal manifestations of extranodal lymphoma: spectrum of imaging findings. AJR Am J Roentgenol, 2008. 191(1): p. 198-206.CrossRefPubMed
5.
Kwee, T.C., R.A. Nievelstein, and D.A. Torigian, Role of Structural Imaging in Lymphoma. PET Clin, 2012. 7(1): p. 1-19.CrossRefPubMed
6.
7.
8.
Paes, F.M., et al., FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics, 2010. 30(1): p. 269-91.CrossRef
9.
Lei, K.I., Primary non-Hodgkin’s lymphoma of the liver. Leuk Lymphoma, 1998. 29(3-4): p. 293-9.PubMed
10.
Page, R.D., et al., Primary hepatic lymphoma: favorable outcome after combination chemotherapy. Cancer, 2001. 92(8): p. 2023-9.CrossRefPubMed
11.
12.
13.
14.
15.
Maher, M.M., et al., Imaging of primary non-Hodgkin’s lymphoma of the liver. Clin Radiol, 2001. 56(4): p. 295-301.CrossRefPubMed
16.
Noronha, V., et al., Primary non-Hodgkin’s lymphoma of the liver. Crit Rev Oncol Hematol, 2005. 53(3): p. 199-207.CrossRefPubMed
17.
Chalamalasetty, S.B., et al., Anaplastic large cell lymphoma presenting as liver abscess and portal vein thrombosis. Indian J Cancer, 2009. 46(3): p. 240-1.CrossRefPubMed
18.
Takeuchi, N. and K. Naba, Primary hepatic lymphoma is difficult to discriminate from a liver abscess. Case Rep Gastrointest Med, 2014. 2014: p. 925307.PubMedPubMedCentral
19.
Tomasian, A., et al., Hematologic malignancies of the liver: spectrum of disease. Radiographics, 2015. 35(1): p. 71-86.CrossRefPubMed
20.
Mahajan, S., et al., Detection of Diffuse Infiltrative Primary Hepatic Lymphoma on FDG PET-CT: Hallmarks of Hepatic Superscan. World J Nucl Med, 2016. 15(2): p. 142-4.CrossRefPubMedPubMedCentral
21.
22.
Ayub, A., et al., Primary Non-Hodgkin’s Lymphoma of the Gallbladder: A Population-based Analysis. Anticancer Res, 2017. 37(5): p. 2581-2586.CrossRefPubMed
23.
Mani, H., et al., Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications. Am J Surg Pathol, 2010. 34(9): p. 1277-86.CrossRefPubMedPubMedCentral
24.
Willen, R. and H. Willen, Primary sarcoma of the gallbladder. A light and electronmicroscopical study. Virchows Arch A Pathol Anat Histol, 1982. 396(1): p. 91-102.
25.
Yamamoto, T., et al., Primary non-Hodgkin’s lymphoma of the gallbladder. AJR Am J Roentgenol, 2005. 184(3 Suppl): p. S86-7.CrossRefPubMed
26.
27.
Ahmann, D.L., et al., Malignant lymphoma of the spleen. A review of 49 cases in which the diagnosis was made at splenectomy. Cancer, 1966. 19(4): p. 461-9.
28.
Dasgupta, T., B. Coombes, and R.D. Brasfield, Primary Malignant Neoplasms of the Spleen. Surg Gynecol Obstet, 1965. 120: p. 947-60.PubMed
29.
Dachman, A.H., et al., Primary non-Hodgkin’s splenic lymphoma. Clin Radiol, 1998. 53(2): p. 137-42.CrossRefPubMed
30.
Li, M., et al., Imaging findings of primary splenic lymphoma: a review of 17 cases in which diagnosis was made at splenectomy. PLoS One, 2013. 8(11): p. e80264.CrossRefPubMedPubMedCentral
31.
Khalid, S., et al., Primary Splenic Diffuse Large B-Cell Lymphoma: A Rare Case of Massive Splenomegaly and Thrombocytopenia. Cureus, 2018. 10(7): p. e3026.PubMedPubMedCentral
32.
Tessier, D.J., et al., Laparoscopic splenectomy for splenic masses. Surg Endosc, 2008. 22(9): p. 2062-6.CrossRefPubMed
33.
Thipphavong, S., et al., Nonneoplastic, benign, and malignant splenic diseases: cross-sectional imaging findings and rare disease entities. AJR Am J Roentgenol, 2014. 203(2): p. 315-22.CrossRefPubMed
34.
Byrd, K.P., et al., Multi-Database Description of Primary Splenic Diffuse Large B-Cell Lymphoma. Anticancer Res, 2017. 37(12): p. 6839-6843.PubMed
35.
36.
Behrns, K.E., M.G. Sarr, and J.G. Strickler, Pancreatic lymphoma: is it a surgical disease? Pancreas, 1994. 9(5): p. 662-7.CrossRefPubMed
37.
Flejou, J.F., [WHO Classification of digestive tumors: the fourth edition]. Ann Pathol, 2011. 31(5 Suppl): p. S27-31.CrossRefPubMed
38.
Abe, Y., et al., Unique intense uptake demonstrated by (18)F-FDG positron emission tomography/computed tomography in primary pancreatic lymphoma: A case report. Oncol Lett, 2010. 1(4): p. 605-607.CrossRefPubMedPubMedCentral
39.
Boninsegna, E., et al., CT imaging of primary pancreatic lymphoma: experience from three referral centres for pancreatic diseases. Insights Imaging, 2018. 9(1): p. 17-24.CrossRefPubMedPubMedCentral
40.
Boninsegna, E., et al., Pancreatic duct stenosis: Differential diagnosis between malignant and benign conditions at secretin-enhanced MRCP. Clin Imaging, 2017. 41: p. 137-143.CrossRefPubMed
41.
Fujinaga, Y., et al., MR features of primary and secondary malignant lymphoma of the pancreas: a pictorial review. Insights Imaging, 2013. 4(3): p. 321-9.CrossRefPubMedPubMedCentral
42.
Mortele, K.J., et al., Multimodality imaging of pancreatic and biliary congenital anomalies. Radiographics, 2006. 26(3): p. 715-31.CrossRefPubMed
43.
44.
45.
Negrelli, R., et al., Pancreatic duct abnormalities in focal autoimmune pancreatitis: MR/MRCP imaging findings. Eur Radiol, 2015. 25(2): p. 359-67.CrossRef
46.
47.
Aziz, S.A., et al., Primary adrenal lymphoma: Differential involvement with varying adrenal function. Indian J Endocrinol Metab, 2011. 15(3): p. 220-3.CrossRefPubMedPubMedCentral
48.
Choi, C.H., et al., Non-Hodgkin’s lymphoma of the adrenal gland. Arch Pathol Lab Med, 1990. 114(8): p. 883-5.PubMed
49.
Rashidi, A. and S.I. Fisher, Primary adrenal lymphoma: a systematic review. Ann Hematol, 2013. 92(12): p. 1583-93.CrossRefPubMed
50.
Venizelos, I., D. Tamiolakis, and G. Petrakis, High grade primary adrenal intravascular large B-cell lymphoma manifesting as Addison disease. Rev Esp Enferm Dig, 2007. 99(8): p. 471-4.CrossRefPubMed
51.
Zhou, L., et al., Primary adrenal lymphoma: radiological; pathological, clinical correlation. Eur J Radiol, 2012. 81(3): p. 401-5.CrossRef
52.
Ichikawa, S., et al., Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma: effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis. Exp Hematol Oncol, 2013. 2(1): p. 19.CrossRefPubMedPubMedCentral
53.
54.
Kato, H., et al., MR imaging of primary adrenal lymphoma. Clin Imaging, 1996. 20(2): p. 126-8.CrossRef
55.
56.
Radhakrishnan, R.K., et al., Unilateral Primary Adrenal Lymphoma: Uncommon Presentation of a Rare Disease Evaluated Using (18)F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. World J Nucl Med, 2018. 17(1): p. 46-48.CrossRefPubMedPubMedCentral
57.
58.
Ganeshan, D., et al., Imaging of primary and secondary renal lymphoma. AJR Am J Roentgenol, 2013. 201(5): p. W712-9.CrossRefPubMed
59.
60.
Bokhari, M.R. and S.R.A. Bokhari, Cancer, Renal Lymphoma, in StatPearls. 2019, StatPearls Publishing LLC.: Treasure Island (FL).
61.
Kandel, L.B., et al., Primary renal lymphoma. Does it exist? Cancer, 1987. 60(3): p. 386-91.
62.
Shetty, S., A.C. Singh, and V. Babu, Primary Renal Lymphoma - A Case Report and Review of Literature. J Clin Diagn Res, 2016. 10(9): p. Xd05-xd07.
63.
Malbrain, M.L., et al., Acute renal failure due to bilateral lymphomatous infiltrates. Primary extranodal non-Hodgkin’s lymphoma (p-EN-NHL) of the kidneys: does it really exist? Clin Nephrol, 1994. 42(3): p. 163-9.
64.
Wagner, J.R., S.C. Honig, and M.B. Siroky, Non-Hodgkin’s lymphoma can mimic renal adenocarcinoma with inferior vena caval involvement. Urology, 1993. 42(6): p. 720-3; discussion 723-4.
65.
Sawa, N., et al., Renal intravascular large B-cell lymphoma localized only within peritubular capillaries. Report of a case. Intern Med, 2007. 46(10): p. 657-62.PubMed
66.
Karaosmanoglu, A.D., et al., Role of multimodality imaging in the diagnosis of lymphoproliferative malignancies and hematologic disorders of the kidneys. Abdom Radiol (NY), 2017. 42(1): p. 242-253.CrossRef
67.
Wong-You-Cheong, J.J., et al., From the Archives of the AFIP: neoplasms of the urinary bladder: radiologic-pathologic correlation. Radiographics, 2006. 26(2): p. 553-80.CrossRefPubMed
68.
Taheri, M.R., et al., Multifaceted genitourinary lymphoma. Curr Probl Diagn Radiol, 2008. 37(2): p. 80-93.CrossRef
69.
Tasu, J.P., et al., Primary malignant lymphoma of the urinary bladder: report of three cases and review of the literature. Eur Radiol, 2000. 10(8): p. 1261-4.CrossRefPubMed
70.
Hughes, M., A. Morrison, and R. Jackson, Primary bladder lymphoma: management and outcome of 12 patients with a review of the literature. Leuk Lymphoma, 2005. 46(6): p. 873-7.CrossRefPubMed
71.
Ohsawa, M., et al., Malignant lymphoma of bladder. Report of three cases and review of the literature. Cancer, 1993. 72(6): p. 1969-74.
72.
Suzuki, T., T. Matsumura, and I. Ito, Intravesical mass consisting of mucosa-associated lymphoid tissue. Int J Urol, 2004. 11(11): p. 1028-30.CrossRefPubMed
73.
Kuhn, N.C.a.A., Case Report about a Primary Bladder Lymphoma. International Archives of Urology and Complications, 2017. 3(3).
74.
Rohena-Quinquilla, I.R., G.E. Lattin, Jr., and D. Wolfman, Imaging of Extranodal Genitourinary Lymphoma. Radiol Clin North Am, 2016. 54(4): p. 747-64.CrossRefPubMed
75.
Bates, A.W., A.J. Norton, and S.I. Baithun, Malignant lymphoma of the urinary bladder: a clinicopathological study of 11 cases. J Clin Pathol, 2000. 53(6): p. 458-61.CrossRefPubMedPubMedCentral
76.
Dahm, P. and J.E. Gschwend, Malignant non-urothelial neoplasms of the urinary bladder: a review. Eur Urol, 2003. 44(6): p. 672-81.CrossRefPubMed
77.
Kumar, N., et al., Primary ovarian lymphoma: a case report and review of literature. J Obstet Gynaecol India, 2014. 64(1): p. 65-7.CrossRefPubMed
78.
Bhartiya, R., et al., Primary Non-Hodgkin’s Lymphoma of the Ovary - A Case Report. J Clin Diagn Res, 2016. 10(5): p. Ed10-1.
79.
Onyiuke, I., A.B. Kirby, and S. McCarthy, Primary gynecologic lymphoma: imaging findings. AJR Am J Roentgenol, 2013. 201(4): p. W648-55.CrossRefPubMed
80.
Fox, H., et al., Malignant lymphoma presenting as an ovarian tumour: a clinicopathological analysis of 34 cases. Br J Obstet Gynaecol, 1988. 95(4): p. 386-90.CrossRefPubMed
81.
Ferrozzi, F., et al., Non-Hodgkin lymphomas of the ovaries: MR findings. J Comput Assist Tomogr, 2000. 24(3): p. 416-20.CrossRefPubMed
82.
Trenhaile, T.R. and M.A. Killackey, Primary pelvic non-Hodgkin’s lymphoma. Obstet Gynecol, 2001. 97(5 Pt 1): p. 717-20.PubMed
83.
Komoto, D., et al., A case of non-hodgkin’s lymphoma of the ovary: usefulness of 18F-FDG PET for staging and assessment of the therapeutic response. Ann Nucl Med, 2006. 20(2): p. 157-60.CrossRefPubMed
84.
Muntz, H.G., et al., Stage IE primary malignant lymphomas of the uterine cervix. Cancer, 1991. 68(9): p. 2023-32.CrossRefPubMed
85.
Dang, H.T., et al., Primary lymphoma of the cervix: MRI findings with gadolinium. Magn Reson Imaging, 1991. 9(6): p. 941-4.CrossRefPubMed
86.
Thyagarajan, M.S., M.J. Dobson, and A. Biswas, Case report: appearance of uterine cervical lymphoma on MRI: a case report and review of the literature. Br J Radiol, 2004. 77(918): p. 512-5.CrossRefPubMed
87.
Bural, G.G., et al., FDG-PET is useful in staging and follow-up of primary uterine cervical lymphoma. Clin Nucl Med, 2007. 32(9): p. 748-50.CrossRefPubMed
88.
Johnston, C., et al., Conservative management of primary cervical lymphoma using combination chemotherapy: a case report. Gynecol Oncol, 1989. 35(3): p. 391-4.CrossRefPubMed
89.
90.
Petrakis, G., et al., Primary prostatic lymphoma with components of both diffuse large B-cell lymphoma (DLBCL) and MALT lymphoma. Hippokratia, 2012. 16(1): p. 86-9.PubMedPubMedCentral
91.
Taleb, A., et al., Primary lymphoma of the prostate treated with rituximab-based chemotherapy: a case report and review of the literature. Cases J, 2009. 2: p. 8875.CrossRefPubMedPubMedCentral
92.
Bostwick, D.G., et al., Malignant lymphoma involving the prostate: report of 62 cases. Cancer, 1998. 83(4): p. 732-8.CrossRefPubMed
93.
Chang, J.M., et al., Pictorial review: Unusual tumours involving the prostate: radiological-pathological findings. Br J Radiol, 2008. 81(971): p. 907-15.CrossRefPubMed
94.
Moller, M.B., F. d’Amore, and B.E. Christensen, Testicular lymphoma: a population-based study of incidence, clinicopathological correlations and prognosis. The Danish Lymphoma Study Group, LYFO. Eur J Cancer, 1994. 30A(12): p. 1760-4.
95.
Cheah, C.Y., A. Wirth, and J.F. Seymour, Primary testicular lymphoma. Blood, 2014. 123(4): p. 486-93.CrossRefPubMed
96.
Vitolo, U., A.J. Ferreri, and E. Zucca, Primary testicular lymphoma. Crit Rev Oncol Hematol, 2008. 65(2): p. 183-9.CrossRefPubMed
97.
98.
Johnson, S., M. Feldman, and V. Krishnamurthi, Primary testicular lymphoma. J Urol, 2015. 193(1): p. 315-6.CrossRefPubMed
99.
Gossios, K., P. Katsimbri, and E. Tsianos, CT features of gastric lymphoma. Eur Radiol, 2000. 10(3): p. 425-30.CrossRefPubMed
100.
Ghai, S., et al., Primary gastrointestinal lymphoma: spectrum of imaging findings with pathologic correlation. Radiographics, 2007. 27(5): p. 1371-88.CrossRefPubMed
101.
Koch, P., et al., Treatment results in localized primary gastric lymphoma: data of patients registered within the German multicenter study (GIT NHL 02/96). J Clin Oncol, 2005. 23(28): p. 7050-9.CrossRef
102.
Wang, Y.G., et al., Clinical characteristics and prognostic factors of primary gastric lymphoma: A retrospective study with 165 cases. Medicine (Baltimore), 2016. 95(31): p. e4250.CrossRef
103.
Yoo, C.C., et al., Gastric mucosa-associated lymphoid tissue lymphoma: radiographic findings in six patients. Radiology, 1998. 208(1): p. 239-43.CrossRefPubMed
104.
Juárez-Salcedo, L.M., et al., Primary Gastric Lymphoma, Epidemiology, Clinical Diagnosis, and Treatment. Cancer Control, 2018. 25(1): p. 1073274818778256.CrossRefPubMedPubMedCentral
105.
Choi, D., et al., Gastric mucosa-associated lymphoid tissue lymphoma: helical CT findings and pathologic correlation. AJR Am J Roentgenol, 2002. 178(5): p. 1117-22.CrossRefPubMed
106.
Park, M.S., et al., Radiographic findings of primary B-cell lymphoma of the stomach: low-grade versus high-grade malignancy in relation to the mucosa-associated lymphoid tissue concept. AJR Am J Roentgenol, 2002. 179(5): p. 1297-304.CrossRefPubMed
107.
Ciftci, A.O., et al., Gastric lymphoma causing gastric outlet obstruction. J Pediatr Surg, 1996. 31(10): p. 1424-6.CrossRefPubMed
108.
Cho, K.C., et al., Transpyloric spread of gastric tumors: comparison of adenocarcinoma and lymphoma. AJR Am J Roentgenol, 1996. 167(2): p. 467-9.CrossRefPubMed
109.
Davis, B.S., T.A. Thompson, and E.A. Wolin, 18F-FDG PET/CT Imaging of Primary Gastric Lymphoma. J Nucl Med Technol, 2016. 44(4): p. 263-264.CrossRefPubMed
110.
111.
Levine, M.S., et al., Non-Hodgkin’s lymphoma of the gastrointestinal tract: radiographic findings. AJR Am J Roentgenol, 1997. 168(1): p. 165-72.CrossRefPubMed
112.
Dawson, I.M., J.S. Cornes, and B.C. Morson, Primary malignant lymphoid tumours of the intestinal tract. Report of 37 cases with a study of factors influencing prognosis. Br J Surg, 1961. 49: p. 80-9.
113.
Lo Re, G., et al., Radiological Features of Gastrointestinal Lymphoma. Gastroenterol Res Pract, 2016. 2016: p. 2498143.PubMed
114.
Lee, H.J., et al., Primary colorectal lymphoma: spectrum of imaging findings with pathologic correlation. Eur Radiol, 2002. 12(9): p. 2242-9.CrossRefPubMed
115.
Dodd, G.D., Lymphoma of the hollow abdominal viscera. Radiol Clin North Am, 1990. 28(4): p. 771-83.PubMed
116.
Beaton, C., M. Davies, and J. Beynon, The management of primary small bowel and colon lymphoma–a review. Int J Colorectal Dis, 2012. 27(5): p. 555-63.CrossRefPubMed
Metadata
Title
Primary lymphomas of the intraabdominal solid organs and the gastrointestinal tract: spectrum of imaging findings with histopathological confirmation
Authors
Ali Devrim Karaosmanoglu
Aycan Uysal
Mehmet Ruhi Onur
Peter F. Hahn
Arzu Saglam Ayhan
Mustafa Nasuh Ozmen
Deniz Akata
Musturay Karcaaltincaba
Publication date
01-09-2019
Publisher
Springer US
Published in
Abdominal Radiology / Issue 9/2019
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-019-02100-5

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