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Strahlentherapie und Onkologie
Published in: Strahlentherapie und Onkologie 10/2020

01-10-2020 | Prostate Cancer | Short Communication

Cone-beam computed tomography-based radiomics in prostate cancer: a mono-institutional study

Authors: Davide Giovanni Bosetti, MD, Lorenzo Ruinelli, Maria Antonietta Piliero, PhD, Prof Linda Christina van der Gaag, Gianfranco Angelo Pesce, MD, Mariacarla Valli, MD, Marco Bosetti, Stefano Presilla, MP, Antonella Richetti, MD, Letizia Deantonio, MD

Published in: Strahlentherapie und Onkologie | Issue 10/2020

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Abstract

Purpose

The purpose of the reported study was to investigate the value of cone-beam computed tomography (CBCT)-based radiomics for risk stratification and prediction of biochemical relapse in prostate cancer.

Methods

The study population consisted of 31 prostate cancer patients. Radiomics features were extracted from weekly CBCT scans performed for verifying treatment position. From the data, logistic-regression models were learned for establishing tumor stage, Gleason score, level of prostate-specific antigen, and risk stratification, and for predicting biochemical recurrence. Performance of the learned models was assessed using the area under the receiver operating characteristic curve (AUC-ROC) or the area under the precision-recall curve (AUC-PRC).

Results

Results suggest that the histogram-based Energy and Kurtosis features and the shape-based feature representing the standard deviation of the maximum diameter of the prostate gland during treatment are predictive of biochemical relapse and indicative of patients at high risk.

Conclusion

Our results suggest the usefulness of CBCT-based radiomics for treatment definition in prostate cancer.
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Metadata
Title
Cone-beam computed tomography-based radiomics in prostate cancer: a mono-institutional study
Authors
Davide Giovanni Bosetti, MD
Lorenzo Ruinelli
Maria Antonietta Piliero, PhD
Prof Linda Christina van der Gaag
Gianfranco Angelo Pesce, MD
Mariacarla Valli, MD
Marco Bosetti
Stefano Presilla, MP
Antonella Richetti, MD
Letizia Deantonio, MD
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 10/2020
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-020-01677-x

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