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Clinical Reviews in Allergy & Immunology
Published in: Clinical Reviews in Allergy & Immunology 3/2022

17-09-2022 | Herpes Virus

The Genetics of Eczema Herpeticum

Authors: Elisabeth Hodara, Peck Y. Ong

Published in: Clinical Reviews in Allergy & Immunology | Issue 3/2022

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Abstract

Eczema herpeticum (EH) is a viral skin infection caused by herpes simplex virus (HSV) superimposed on eczematous skin lesions in atopic dermatitis (AD). Though the pathogenesis of EH has yet to be fully elucidated, the fact that EH is relatively rare despite a majority of adults showing serologic evidence of HSV exposure points to a genetic component predisposing to the disease. A number of genetic variants have been isolated in EH which may help distinguish a subgroup of patients susceptible to developing the condition. These unique genetic characteristics include deficiencies in skin barrier function and hydration, as well as at the level of the immune system. In this review, we summarize the genetic findings associated with EH identified to date. Isolating genetic markers in EH will be instrumental in stratifying patients at risk for EH and will have significant implications in the development and tailoring of targeted therapies.
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Metadata
Title
The Genetics of Eczema Herpeticum
Authors
Elisabeth Hodara
Peck Y. Ong
Publication date
17-09-2022
Publisher
Springer US
Published in
Clinical Reviews in Allergy & Immunology / Issue 3/2022
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-022-08953-x

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