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Langenbeck's Archives of Surgery

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01-12-2016 | ORIGINAL ARTICLE

Lymph node ratio as parameter of regional lymph node involvement in pancreatic cancer

Authors: Suguru Yamada, Tsutomu Fujii, Akihiro Hirakawa, Mitsuro Kanda, Hiroyuki Sugimoto, Yasuhiro Kodera

Published in: Langenbeck's Archives of Surgery | Issue 8/2016

Abstract

Purpose

To determine which indicators, anatomical nodal metastasis (Japan Pancreas Society, JPS), number of positive lymph nodes (PLN), or lymph node ratio (LNR), is the best means of assessing lymph node involvement in pancreatic cancer.

Methods

This retrospective study analyzed 275 patients with pancreatic cancer treated at a single institution. Survival curves according to the JPS, PLN, or LNR were assessed by the Kaplan–Meier method. Prognostic value of each classification was explored by Cox regression analysis after adjustments for clinical factors.

Results

Multivariate analysis showed that, relative to n0 in the JPS, hazard ratios (HR) in n1, n2, and n3 were 1.72, 1.73, and 2.75, respectively, with no difference in survival between n1 and n2. Relative to PLN of 0, the HR in the PLN categories of 1∼2, 3, and >3 were 1.39, 1.65, and 3.03, respectively. Relative to LNR of 0, the HR in the categories of 0 < LNR ≤ 0.1, 0.1 < LNR ≤ 0.2, and LNR > 0.2 were 1.27, 2.00, and 5.58, respectively. An incremental increase in the HR was observed as the LNR category progressed, and differences between the survivals were distinct when stratified by the LNR.

Conclusions

The LNR was an accurate predictor of survival among three assessment strategies and could be proposed as a candidate for use as N categories, pending validation studies.

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Title: Lymph node ratio as parameter of regional lymph node involvement in pancreatic cancer
Authors: Suguru Yamada
Tsutomu Fujii
Akihiro Hirakawa
Mitsuro Kanda
Hiroyuki Sugimoto
Yasuhiro Kodera
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 8/2016
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-016-1412-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Lymph node ratio as parameter of regional lymph node involvement in pancreatic cancer

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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