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European Radiology
Published in: European Radiology 10/2016

01-10-2016 | Nuclear Medicine

PET/MRI of central nervous system: current status and future perspective

Authors: Zhen Lu Yang, Long Jiang Zhang

Published in: European Radiology | Issue 10/2016

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Abstract

Imaging plays an increasingly important role in the early diagnosis, prognosis prediction and therapy response evaluation of central nervous system (CNS) diseases. The newly emerging hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) can perform “one-stop-shop” evaluation, including anatomic, functional, biochemical and metabolic information, even at the molecular level, for personalised diagnoses and treatments of CNS diseases. However, there are still several problems to be resolved, such as appropriate PET detectors, attenuation correction and so on. This review will introduce the basic physical principles of PET/MRI and its potential clinical applications in the CNS. We also provide the future perspectives for this field.

Key Points

• PET/MRI can simultaneously provide anatomic, functional, biochemical and metabolic information.
• PET/MRI has promising potential in various central nervous system diseases.
• Research on the future implementation of PET/MRI is challenging and encouraging.
Literature
1.
Global Burden of Disease Study 2013 Collaborators (2015) Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 386:743–800CrossRefPubMedCentral
2.
3.
Littooij AS, Torigian DA, Kwee TC et al (2013) Potential clinical applications of PET/magnetic resonance imaging. PET Clin 8:367–384CrossRefPubMed
4.
Kierans A, Parikh N, Chandarana H (2015) Recent advances in MR hardware and software. Radiol Clin North Am 53:599–610CrossRefPubMed
5.
Veit-Haibach P, Kuhn FP, Wiesinger F et al (2013) PET-MR imaging using a tri-modality PET/CT-MR system with a dedicated shuttle in clinical routine. MAGMA 26:25–35CrossRefPubMed
6.
Wehner J, Weissler B, Dueppenbecker P et al (2014) PET/MRI insert using digital SiPMs: investigation of MR-compatibility. Nucl Inst Methods Phys Res A 734:116–121CrossRef
7.
Rakheja R, Chandarana H, Ponzo F et al (2014) Fluorodeoxyglucose positron emission tomography/magnetic resonance imaging: current status, future aspects. PET Clin 9:237–252CrossRefPubMed
8.
Herzog H, Pietrzyk U, Shah NJ et al (2010) The current state, challenges and perspectives of MR-PET. NeuroImage 49:2072–2082CrossRefPubMed
9.
Yoon HS, Ko GB, Kwon SI et al (2012) Initial results of simultaneous PET/MRI experiments with an MRI-compatible silicon photomultiplier PET scanner. J Nucl Med 53:608–614CrossRefPubMed
10.
Keereman V, Van Holen R, Vandenberghe S et al (2013) Temperature dependence of APD-based PET scanners. Med Phys 40:092506CrossRefPubMed
11.
Kim H, Chen CT, Eclov N et al (2015) A feasibility study of a PET/MRI insert detector using strip-line and waveform sampling data acquisition. Nucl Inst Methods Phys Res A 784:557–564CrossRef
12.
Barnwell J, Raptis CA, McConathy JE et al (2015) Beyond whole-body imaging advanced imaging techniques of PET/MRI. Clin Nucl Med 40:e88–e95CrossRefPubMed
13.
Paulus DH, Quick HH, Geppert C et al (2015) Whole-body PET/MR imaging: quantitative evaluation of a novel model-based MR attenuation correction method including bone. J Nucl Med 56:1061–1066CrossRefPubMedPubMedCentral
14.
Partovi S, Kohan A, Rubbert C et al (2014) Clinical oncologic applications of PET/MRI: a new horizon. Am J Nucl Med Mol Imaging 4:202–212PubMedPubMedCentral
15.
Werner P, Barthel H, Drzezga A et al (2015) Current status and future role of brain PET/MRI in clinical and research settings. Eur J Nucl Med Mol Imaging 42:512–526CrossRefPubMed
16.
Aasheim LB, Karlberg A, Goa PE et al (2015) PET/MR brain imaging: evaluation of clinical UTE-based attenuation correction. Eur J Nucl Med Mol Imaging 42:1439–1446CrossRefPubMed
17.
Cabello J, Lukas M, Förster S et al (2015) MR-based attenuation correction using ultrashort-echo-time pulse sequences in dementia patients. J Nucl Med 56:423–429CrossRefPubMed
18.
Manber R, Thielemans K, Hutton BF et al (2015) Practical PET respiratory motion correction in clinical PET/MR. J Nucl Med 56:890–896CrossRefPubMed
19.
Leemans EL, Kotasidis F, Wissmeyer M et al (2015) Qualitative and quantitative evaluation of blob-based time-of-flight PET image reconstruction in hybrid brain PET/MR imaging. Mol Imaging Biol 17:704–713CrossRefPubMedPubMedCentral
20.
Barthel H, Schroeter ML, Hoffmann KT et al (2015) PET/MR in dementia and other neurodegenerative diseases. Semin Nucl Med 45:224–233CrossRefPubMed
21.
Bhogal P, Mahoney C, Graeme-Baker S et al (2013) The common dementias: a pictorial review. Eur Radiol 23:3405–3417CrossRefPubMed
22.
Rocchi L, Niccolini F, Politis M et al (2015) Recent imaging advances in neurology. J Neurol 262:2182–2194CrossRefPubMed
23.
Barthel H, Gertz HJ, Dresel S et al (2011) Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol 10:424–435CrossRefPubMed
24.
Yousefi BH, Manook A, Grimmer T et al (2015) Characterization and first human investigation of FIBT, a novel fluorinated Abeta plaque neuroimaging PET radioligand. ACS Chem Neurosci 6:428–437CrossRefPubMed
25.
Barkhof F, Haller S, Rombouts SA (2014) Resting-state functional MR imaging: a new window to the brain. Radiology 272:29–49CrossRefPubMed
26.
27.
Zhang LJ, Wen J, Liang X et al (2015) Brain default mode network changes after renal transplantation: a diffusion-tensor imaging and resting-state functional MR imaging study. Radiology
28.
Luo S, Qi RF, Wen JQ et al (2016) Abnormal intrinsic brain activity patterns in patients with end-stage renal disease undergoing peritoneal dialysis: a resting-state functional MR imaging study. Radiology 278:181–189
29.
Ni L, Wen J, Zhang LJ et al (2014) Aberrant default-mode functional connectivity in patients with end-stage renal disease: a resting-state functional MR imaging study. Radiology 271:543–552CrossRefPubMed
30.
Celebi O, Uzdogan A, Oguz KK et al (2016) Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease. Arch Gerontol Geriatr 62:125–132CrossRefPubMed
31.
Wang P, Zhou B, Yao H et al (2015) Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment. Sci Rep 5:14824CrossRefPubMedPubMedCentral
32.
Verclytte S, Lopes R, Delmaire C et al (2015) Optimization of brain perfusion image quality by cortical surface-based projection of arterial spin labeling maps in early-onset Alzheimer's disease patients. Eur Radiol 25:2479–2484CrossRefPubMed
33.
Wang R, Yu S, Alger JR et al (2014) Multi-delay arterial spin labeling perfusion MRI in moyamoya disease--comparison with CT perfusion imaging. Eur Radiol 24:1135–1144CrossRefPubMedPubMedCentral
34.
Binnewijzend MA, Benedictus MR, Kuijer JP et al (2015) Cerebral perfusion in the predementia stages of Alzheimer's disease. Eur Radiol
35.
Binnewijzend MA, Kuijer JP, Benedictus MR et al (2013) Cerebral blood flow measured with 3D pseudocontinuous arterial spin-labeling MR imaging in Alzheimer disease and mild cognitive impairment: a marker for disease severity. Radiology 267:221–230CrossRefPubMed
36.
Binnewijzend MA, Kuijer JP, van der Flier WM et al (2014) Distinct perfusion patterns in Alzheimer's disease, frontotemporal dementia and dementia with Lewy bodies. Eur Radiol 24:2326–2333CrossRefPubMed
37.
Verfaillie SC, Adriaanse SM, Binnewijzend MA et al (2015) Cerebral perfusion and glucose metabolism in Alzheimer's disease and frontotemporal dementia: two sides of the same coin? Eur Radiol 25:3050–3059CrossRefPubMedPubMedCentral
38.
Steketee RM, Bron EE, Meijboom R et al (2016) Early-stage differentiation between presenile Alzheimer's disease and frontotemporal dementia using arterial spin labeling MRI. Eur Radiol 26:244–253CrossRefPubMed
39.
Tahmasian M, Pasquini L, Scherr M et al (2015) The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease. Neurology 84:1956–1963CrossRefPubMed
40.
Kim E, Howes OD, Kapur S (2013) Molecular imaging as a guide for the treatment of central nervous system disorders. Dialogues Clin Neurosci 15:315–328PubMedPubMedCentral
41.
Pavese N, Simpson BS, Metta V et al (2012) [18F]FDOPA uptake in the raphe nuclei complex reflects serotonin transporter availability. A combined [18F]FDOPA and [11C]DASB PET study in Parkinson's disease. NeuroImage 59:1080–1084CrossRefPubMed
42.
Pavese N, Metta V, Bose SK et al (2010) Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction. Brain 133:3434–3443CrossRefPubMed
43.
Calabresi P, Picconi B, Tozzi A et al (2016) Interaction between basal ganglia and limbic circuits in learning and memory processes. Parkinsonism Relat Disord 22:S65–S68CrossRefPubMed
44.
Lee KD, Koo JH, Song SH et al (2015) Central cholinergic dysfunction could be associated with oropharyngeal dysphagia in early Parkinson's disease. J Neural Transm (Vienna) 122:1553–1561CrossRef
45.
Georgiev D, Jahanshahi M, Dreo J et al (2015) Dopaminergic medication alters auditory distractor processing in Parkinson's disease. Acta Psychol (Amst) 156:45–56CrossRef
46.
Ding W, Ding LJ, Li FF et al (2015) Neurodegeneration and cognition in Parkinson's disease: a review. Eur Rev Med Pharmacol Sci 19:2275–2281PubMed
47.
Hellwig S, Frings L, Amtage F et al (2015) 18F-FDG PET is an early predictor of overall survival in suspected atypical parkinsonism. J Nucl Med 56:1541–1546CrossRefPubMed
48.
Kimura M, Da Cruz LC Jr (2016) Multiparametric MR imaging in the assessment of brain tumors. Magn Reson Imaging Clin N Am 24:87–122CrossRefPubMed
49.
Bailey PD, Zacà D, Basha MM et al (2015) Presurgical fMRI and DTI for the prediction of perioperative motor and language deficits in primary or metastatic brain lesions. J Neuroimaging 25:776–784CrossRefPubMed
50.
Neuner I, Kaffanke JB, Langen KJ et al (2012) Multimodal imaging utilising integrated MR-PET for human brain tumour assessment. Eur Radiol 22:2568–2580CrossRefPubMed
51.
Senthamizhchelvan S, Zaidi H (2013) Novel quantitative techniques in hybrid (PET-MR) imaging of brain tumors. PET Clin 8:219–232CrossRefPubMed
52.
Thorwarth D, Müller AC, Pfannenberg C et al (2013) Combined PET/MRimaging using (68)Ga-DOTATOC for radiotherapy treatment planning in meningioma patients. Recent Results Cancer Res 194:425–439CrossRefPubMed
53.
Ishiyama M, Richards T, Parvathaneni U et al (2015) Dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer: differentiation of new H&N cancer, recurrent disease, and benign post-treatment changes. Clin Imaging 39:566–570CrossRefPubMed
54.
Varoquaux A, Rager O, Dulguerov P et al (2015) Diffusion-weighted and PET/MR imaging after radiation therapy for malignant head and neck tumors. Radiographics 35:1502–1527CrossRefPubMed
55.
Yoon JH, Kim JH, Kang WJ et al (2014) Grading of cerebral glioma with multiparametric MR imaging and 18F-FDG-PET: concordance and accuracy. Eur Radiol 24:380–389CrossRefPubMed
56.
Dunet V, Maeder P, Nicod-Lalonde M et al (2014) Combination of MRI and dynamic FET PET for initial glioma grading. Nuklearmedizin 53:155–161CrossRefPubMed
57.
Barajas RF Jr, Pampaloni MH, Clarke JL et al (2015) Assessing biological response to bevacizumab using 18F-fluoromisonidazole PET/MR imaging in a patient with recurrent anaplastic astrocytoma. Case Rep Radiol 2015:731361PubMedPubMedCentral
58.
Kickingereder P, Radbruch A, Burth S et al (2015) MR perfusion-derived hemodynamic parametric response mapping of bevacizumab efficacy in recurrent glioblastoma. Radiology
59.
Fraioli F, Shankar A, Hargrave D et al (2015) 18F-fluoroethylcholine (18F-Cho) PET/MRI functional parameters in pediatric astrocytic brain tumors. Clin Nucl Med 40:e40–e45CrossRefPubMed
60.
Morana G, Piccardo A, Milanaccio C et al (2014) Value of 18F-3,4-dihydroxyphenylalanine PET/MR image fusion in pediatric supratentorial infiltrative astrocytomas: a prospective pilot study. J Nucl Med 55:718–723CrossRefPubMed
61.
Shin HW, Jewells V, Sheikh A et al (2015) Initial experience in hybrid PET-MRI for evaluation of refractory focal onset epilepsy. Seizure 31:1–4CrossRefPubMed
62.
Grouiller F, Delattre BM, Pittau F et al (2015) All-in-one interictal presurgical imaging in patients with epilepsy: single-session EEG/PET/(f)MRI. Eur J Nucl Med Mol Imaging 42:1133–1143CrossRefPubMed
63.
Ding YS, Chen BB, Glielmi C et al (2014) A pilot study in epilepsy patients using simultaneous PET/MR. Am J Nucl Med Mol Imaging 4:459–470PubMedPubMedCentral
64.
Yang Y, Hu W, Jiang S et al (2015) The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases. Biochim Biophys Acta 1852:1887–1894CrossRefPubMed
65.
66.
67.
Campbell BC, Mitchell PJ, Kleinig TJ et al (2015) Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 372:1009–1018CrossRefPubMed
68.
Grade M, Hernandez Tamames JA, Pizzini FB et al (2015) A neuroradiologist's guide to arterial spin labeling MRI in clinical practice. Neuroradiology 57:1181–1202CrossRefPubMedPubMedCentral
69.
Yan L, Liu CY, Smith RX et al (2016) Assessing intracranial vascular compliance using dynamic arterial spin labeling. Neuroimage 24:433–441CrossRef
70.
Catana C, Drzezga A, Heiss WD et al (2012) PET/MRI for neurologic applications. J Nucl Med 53:1916–1925CrossRefPubMed
71.
72.
Banaszek A, Bladowska J, Pokryszko-Dragan A et al (2015) Evaluation of the degradation of the selected projectile, commissural and association white matter tracts within normal appearing white matter in patients with multiple sclerosis using diffusion tensor MR imaging–a preliminary study. Pol J Radiol 80:457–463CrossRefPubMedPubMedCentral
73.
Gracien RM, Reitz SC, Hof SM et al (2015) Changes and variability of proton density and T1 relaxation times in early multiple sclerosis: MRI markers of neuronal damage in the cerebral cortex. Eur Radiol
74.
Saake M, Langner S, Schwenke C (2015) MRI in multiple sclerosis: an intra-individual, randomized and multicentric comparison of gadobutrol with gadoterate meglumine at 3 T. Eur Radiol
75.
Rudko DA, Solovey I, Gati JS et al (2014) Multiple sclerosis: improved identification of disease-relevant changes in gray and white matter by using susceptibility-based MR imaging. Radiology 272:851–864CrossRefPubMed
76.
Bolcaen J, Acou M, Mertens K et al (2013) Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study. J Neuroimaging 23:431–436CrossRefPubMed
77.
Matías-Guiu JA, Cabrera-Martín MN, Matías-Guiu J et al (2015) Amyloid PET imaging in multiple sclerosis: an (18)F-florbetaben study. BMC Neurol 15:243CrossRefPubMedPubMedCentral
78.
Torigian DA, Zaidi H, Kwee TC et al (2013) PET/MR imaging: technical aspects and potential clinical applications. Radiology 267:26–44CrossRefPubMed
79.
Aiello M, Salvatore E, Cachia A et al (2015) Relationship between simultaneously acquired resting-state regional cerebral glucose metabolism and functional MRI: a PET/MR hybrid scanner study. NeuroImage 113:111–121CrossRefPubMed
Metadata
Title
PET/MRI of central nervous system: current status and future perspective
Authors
Zhen Lu Yang
Long Jiang Zhang
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 10/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-4202-5

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