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Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 1/2013

01-02-2013 | Review Article

PET–MR imaging using a tri-modality PET/CT–MR system with a dedicated shuttle in clinical routine

Authors: Patrick Veit-Haibach, Felix Pierre Kuhn, Florian Wiesinger, Gaspar Delso, Gustav von Schulthess

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2013

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Abstract

Tri-modality PET/CT–MRI includes the transfer of the patient on a dedicated shuttle from one system into the other. Advantages of this system include a true CT-based attenuation correction, reliable PET-quantification and higher flexibility in patient throughput on both systems. Comparative studies of PET/MRI versus PET/CT are readily accomplished without repeated PET with a different PET scanner at a different time point. Additionally, there is a higher imaging flexibility based on the availability of three imaging modalities, which can be combined for the characterization of the disease. The downside is a somewhat higher radiation dose of up to 3 mSv with a low dose CT based on the CT-component, longer acquisition times and potential misalignment between the imaging components. Overall, the tri-modality PET/CT–MR system offers comparative studies using the three different imaging modalities in the same patient virtually at the same time, and may help to develop reliable attenuation algorithms at the same time.
Literature
1.
go back to reference Schwenzer NF, Schmidt H, Claussen CD (2012) Whole-body MR/PET: applications in abdominal imaging. Abdom Imaging 37(1):20–28PubMedCrossRef Schwenzer NF, Schmidt H, Claussen CD (2012) Whole-body MR/PET: applications in abdominal imaging. Abdom Imaging 37(1):20–28PubMedCrossRef
2.
go back to reference Beyer T, Freudenberg LS, Czernin J, Townsend DW (2011) The future of hybrid imaging-part 3: PET/MR, small-animal imaging and beyond. Insights Imaging 2(3):235–246PubMedCrossRef Beyer T, Freudenberg LS, Czernin J, Townsend DW (2011) The future of hybrid imaging-part 3: PET/MR, small-animal imaging and beyond. Insights Imaging 2(3):235–246PubMedCrossRef
3.
go back to reference Ratib O, Beyer T (2011) Whole-body hybrid PET/MRI: ready for clinical use? Eur J Nucl Med Mol Imaging 38(6):992–995PubMedCrossRef Ratib O, Beyer T (2011) Whole-body hybrid PET/MRI: ready for clinical use? Eur J Nucl Med Mol Imaging 38(6):992–995PubMedCrossRef
4.
go back to reference Park H, Wood D, Hussain H, Meyer CR, Shah RB, Johnson TD, Chenevert T, Piert M (2012) Introducing parametric fusion PET/MRI of primary prostate cancer. J Nucl Med 53(4):546–551PubMedCrossRef Park H, Wood D, Hussain H, Meyer CR, Shah RB, Johnson TD, Chenevert T, Piert M (2012) Introducing parametric fusion PET/MRI of primary prostate cancer. J Nucl Med 53(4):546–551PubMedCrossRef
5.
go back to reference Jambor I, Borra R, Kemppainen J, Lepomaki V, Parkkola R, Dean K, Alanen K, Arponen E, Nurmi M, Aronen HJ, Minn H (2012) Improved detection of localized prostate cancer using co-registered MRI and (11)C-acetate PET/CT. Eur J Radiol. Feb 17 (Epub ahead of print) Jambor I, Borra R, Kemppainen J, Lepomaki V, Parkkola R, Dean K, Alanen K, Arponen E, Nurmi M, Aronen HJ, Minn H (2012) Improved detection of localized prostate cancer using co-registered MRI and (11)C-acetate PET/CT. Eur J Radiol. Feb 17 (Epub ahead of print)
6.
go back to reference Appenzeller P, Mader C, Schmidt D, Schmid D, Veit-Haibach P (2012) Low-dose PET/CT vs. fast body coil PET/MRI—how low can you go?. In: Proceedings of the 14th scientific meeting, Asean Oceanen Congress of Radiology, Sydney, New South Wales, Australia, EPOS 364.00 Appenzeller P, Mader C, Schmidt D, Schmid D, Veit-Haibach P (2012) Low-dose PET/CT vs. fast body coil PET/MRI—how low can you go?. In: Proceedings of the 14th scientific meeting, Asean Oceanen Congress of Radiology, Sydney, New South Wales, Australia, EPOS 364.00
7.
go back to reference Assiri Y, Kuhn FP, Pietsch C, Schmidt D, Veit-Haibach P (2012) Contrast-enhanced PET/CT vs. non-contrast enhanced PET/MRI in abdominal oncological lesions—initial results. In: Proceedings of the 14th scientific meeting, Asean Oceanen Congress of Radiology, Sydney, New South Wales, Australia, p 23 Assiri Y, Kuhn FP, Pietsch C, Schmidt D, Veit-Haibach P (2012) Contrast-enhanced PET/CT vs. non-contrast enhanced PET/MRI in abdominal oncological lesions—initial results. In: Proceedings of the 14th scientific meeting, Asean Oceanen Congress of Radiology, Sydney, New South Wales, Australia, p 23
8.
go back to reference Eiber M, Martinez-Moller A, Souvatzoglou M, Holzapfel K, Pickhard A, Loffelbein D, Santi I, Rummeny EJ, Ziegler S, Schwaiger M, Nekolla SG, Beer AJ (2011) Value of a Dixon-based MR/PET attenuation correction sequence for the localization and evaluation of PET-positive lesions. Eur J Nucl Med Mol Imaging 38(9):1691–1701PubMedCrossRef Eiber M, Martinez-Moller A, Souvatzoglou M, Holzapfel K, Pickhard A, Loffelbein D, Santi I, Rummeny EJ, Ziegler S, Schwaiger M, Nekolla SG, Beer AJ (2011) Value of a Dixon-based MR/PET attenuation correction sequence for the localization and evaluation of PET-positive lesions. Eur J Nucl Med Mol Imaging 38(9):1691–1701PubMedCrossRef
9.
go back to reference Pfannenberg C, Schraml C, Schwenzer N, Werner M, Muller M, Bares R, Claussen CD (2011) Comparison of [68 Ga] DOTATOC-PET/CT and whole-body MRI in staging of neuroendocrine tumors. Cancer Imaging 11(Spec No A):S38–S39CrossRef Pfannenberg C, Schraml C, Schwenzer N, Werner M, Muller M, Bares R, Claussen CD (2011) Comparison of [68 Ga] DOTATOC-PET/CT and whole-body MRI in staging of neuroendocrine tumors. Cancer Imaging 11(Spec No A):S38–S39CrossRef
10.
go back to reference Yong TW, Yuan ZZ, Jun Z, Lin Z, He WZ, Juanqi Z (2011) Sensitivity of PET/MR images in liver metastases from colorectal carcinoma. Hell J Nucl Med 14(3):264–268PubMed Yong TW, Yuan ZZ, Jun Z, Lin Z, He WZ, Juanqi Z (2011) Sensitivity of PET/MR images in liver metastases from colorectal carcinoma. Hell J Nucl Med 14(3):264–268PubMed
11.
go back to reference Drzezga A, Souvatzoglou M, Eiber M, Beer AJ, Furst S, Martinez-Moller A, Nekolla SG, Ziegler S, Ganter C, Rummeny EJ, Schwaiger M (2012) First clinical experience with integrated whole-body PET/MR: comparison to PET/CT in patients with oncologic diagnoses. J Nucl Med 53(6):845–855PubMedCrossRef Drzezga A, Souvatzoglou M, Eiber M, Beer AJ, Furst S, Martinez-Moller A, Nekolla SG, Ziegler S, Ganter C, Rummeny EJ, Schwaiger M (2012) First clinical experience with integrated whole-body PET/MR: comparison to PET/CT in patients with oncologic diagnoses. J Nucl Med 53(6):845–855PubMedCrossRef
12.
go back to reference Hofmann M, Pichler B, Scholkopf B, Beyer T (2009) Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques. Eur J Nucl Med Mol Imaging 36(Suppl 1):S93–104PubMedCrossRef Hofmann M, Pichler B, Scholkopf B, Beyer T (2009) Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques. Eur J Nucl Med Mol Imaging 36(Suppl 1):S93–104PubMedCrossRef
13.
go back to reference Keereman V, Fierens Y, Broux T, De Deene Y, Lonneux M, Vandenberghe S (2010) MRI-based attenuation correction for PET/MRI using ultrashort echo time sequences. J Nucl Med 51(5):812–818PubMedCrossRef Keereman V, Fierens Y, Broux T, De Deene Y, Lonneux M, Vandenberghe S (2010) MRI-based attenuation correction for PET/MRI using ultrashort echo time sequences. J Nucl Med 51(5):812–818PubMedCrossRef
14.
go back to reference Schwenzer NF, Schraml C, Muller M, Brendle C, Sauter A, Spengler W, Pfannenberg AC, Claussen CD, Schmidt H (2012) Pulmonary lesion assessment: comparison of whole-body hybrid MR/PET and PET/CT imaging—pilot study. Radiology. doi:10.1148/radiol.12111942 PubMed Schwenzer NF, Schraml C, Muller M, Brendle C, Sauter A, Spengler W, Pfannenberg AC, Claussen CD, Schmidt H (2012) Pulmonary lesion assessment: comparison of whole-body hybrid MR/PET and PET/CT imaging—pilot study. Radiology. doi:10.​1148/​radiol.​12111942 PubMed
15.
go back to reference Vogt FM, Herborn CU, Hunold P, Lauenstein TC, Schroder T, Debatin JF, Barkhausen J (2004) HASTE MRI versus chest radiography in the detection of pulmonary nodules: comparison with MDCT. AJR Am J Roentgenol 183(1):71–78PubMed Vogt FM, Herborn CU, Hunold P, Lauenstein TC, Schroder T, Debatin JF, Barkhausen J (2004) HASTE MRI versus chest radiography in the detection of pulmonary nodules: comparison with MDCT. AJR Am J Roentgenol 183(1):71–78PubMed
16.
go back to reference Samarin A, Burger C, Wollenweber SD, Crook DW, Burger IA, Schmid DT, von Schulthess GK, Kuhn FP (2012) PET/MR imaging of bone lesions–implications for PET quantification from imperfect attenuation correction. Eur J Nucl Med Mol Imaging 39(7):1154–1160PubMedCrossRef Samarin A, Burger C, Wollenweber SD, Crook DW, Burger IA, Schmid DT, von Schulthess GK, Kuhn FP (2012) PET/MR imaging of bone lesions–implications for PET quantification from imperfect attenuation correction. Eur J Nucl Med Mol Imaging 39(7):1154–1160PubMedCrossRef
17.
go back to reference Beyer T, Weigert M, Quick HH, Pietrzyk U, Vogt F, Palm C, Antoch G, Muller SP, Bockisch A (2008) MR-based attenuation correction for torso-PET/MR imaging: pitfalls in mapping MR to CT data. Eur J Nucl Med Mol Imaging 35(6):1142–1146PubMedCrossRef Beyer T, Weigert M, Quick HH, Pietrzyk U, Vogt F, Palm C, Antoch G, Muller SP, Bockisch A (2008) MR-based attenuation correction for torso-PET/MR imaging: pitfalls in mapping MR to CT data. Eur J Nucl Med Mol Imaging 35(6):1142–1146PubMedCrossRef
18.
go back to reference Schramm G, Langner F, Hofheinz F, Beuthien-Baumann B, Platzek I, Petr J, Kotzerke J, Steinbach J, van den Hoff J (2012) Quantitative accuracy of attenuation correction in the Philips Ingenuity TF whole-body PET/MR system: a direct comparison with transmission-based attenuation correction. Magn Reson Mater Phy. doi:10.1007/s10334-012-0328-5 Schramm G, Langner F, Hofheinz F, Beuthien-Baumann B, Platzek I, Petr J, Kotzerke J, Steinbach J, van den Hoff J (2012) Quantitative accuracy of attenuation correction in the Philips Ingenuity TF whole-body PET/MR system: a direct comparison with transmission-based attenuation correction. Magn Reson Mater Phy. doi:10.​1007/​s10334-012-0328-5
19.
go back to reference Stolzmann P, Veit-Haibach P, Chuck N, Rossi C, Frauenfelder T, Alkadhi H, von Schulthess GK, Boss A (2012) Detection rate, location, and size of pulmonary nodules in tri-modality PET/CT-MR: comparison of low-dose CT and Dixon-based MR imaging. Invest Radiol (in press) Stolzmann P, Veit-Haibach P, Chuck N, Rossi C, Frauenfelder T, Alkadhi H, von Schulthess GK, Boss A (2012) Detection rate, location, and size of pulmonary nodules in tri-modality PET/CT-MR: comparison of low-dose CT and Dixon-based MR imaging. Invest Radiol (in press)
20.
go back to reference Samarin A, Kuhn FP, Crook DW, Hodler J, Von Schulthess GK, Schmid DT, Wiesinger F, Wollenweber S (2011) Image registration accuracy of a sequential, trimodality PET/CT + MR imaging setup using dedicated patient transporter systems. In: Proceedings of the 97th Radiological Society of North America 2011 scientific assembly and annual meeting. Chicago IL, SSK13-08 Samarin A, Kuhn FP, Crook DW, Hodler J, Von Schulthess GK, Schmid DT, Wiesinger F, Wollenweber S (2011) Image registration accuracy of a sequential, trimodality PET/CT + MR imaging setup using dedicated patient transporter systems. In: Proceedings of the 97th Radiological Society of North America 2011 scientific assembly and annual meeting. Chicago IL, SSK13-08
21.
go back to reference Zaidi H, Hasegawa B (2003) Determination of the attenuation map in emission tomography. J Nucl Med 44(2):291–315PubMed Zaidi H, Hasegawa B (2003) Determination of the attenuation map in emission tomography. J Nucl Med 44(2):291–315PubMed
22.
go back to reference Martinez-Moller A, Souvatzoglou M, Delso G, Bundschuh RA, Chefd’hotel C, Ziegler SI, Navab N, Schwaiger M, Nekolla SG (2009) Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data. J Nucl Med 50(4):520–526PubMedCrossRef Martinez-Moller A, Souvatzoglou M, Delso G, Bundschuh RA, Chefd’hotel C, Ziegler SI, Navab N, Schwaiger M, Nekolla SG (2009) Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data. J Nucl Med 50(4):520–526PubMedCrossRef
23.
go back to reference Hofmann M, Bezrukov I, Mantlik F, Aschoff P, Steinke F, Beyer T, Pichler BJ, Scholkopf B (2011) MRI-based attenuation correction for whole-body PET/MRI: quantitative evaluation of segmentation- and atlas-based methods. J Nucl Med 52(9):1392–1399PubMedCrossRef Hofmann M, Bezrukov I, Mantlik F, Aschoff P, Steinke F, Beyer T, Pichler BJ, Scholkopf B (2011) MRI-based attenuation correction for whole-body PET/MRI: quantitative evaluation of segmentation- and atlas-based methods. J Nucl Med 52(9):1392–1399PubMedCrossRef
24.
go back to reference Hofmann M, Steinke F, Scheel V, Charpiat G, Farquhar J, Aschoff P, Brady M, Scholkopf B, Pichler BJ (2008) MRI-based attenuation correction for PET/MRI: a novel approach combining pattern recognition and atlas registration. J Nucl Med 49(11):1875–1883PubMedCrossRef Hofmann M, Steinke F, Scheel V, Charpiat G, Farquhar J, Aschoff P, Brady M, Scholkopf B, Pichler BJ (2008) MRI-based attenuation correction for PET/MRI: a novel approach combining pattern recognition and atlas registration. J Nucl Med 49(11):1875–1883PubMedCrossRef
25.
go back to reference Malone IB, Ansorge RE, Williams GB, Nestor PJ, Carpenter TA, Fryer TD (2011) Attenuation correction methods suitable for brain imaging with a PET/MRI scanner: a comparison of tissue atlas and template attenuation map approaches. J Nucl Med 52(7):1142–1149PubMedCrossRef Malone IB, Ansorge RE, Williams GB, Nestor PJ, Carpenter TA, Fryer TD (2011) Attenuation correction methods suitable for brain imaging with a PET/MRI scanner: a comparison of tissue atlas and template attenuation map approaches. J Nucl Med 52(7):1142–1149PubMedCrossRef
26.
go back to reference Catana C, van der Kouwe A, Benner T, Michel CJ, Hamm M, Fenchel M, Fischl B, Rosen B, Schmand M, Sorensen AG (2011) Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype. J Nucl Med 51(9):1431–1438CrossRef Catana C, van der Kouwe A, Benner T, Michel CJ, Hamm M, Fenchel M, Fischl B, Rosen B, Schmand M, Sorensen AG (2011) Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype. J Nucl Med 51(9):1431–1438CrossRef
27.
go back to reference Rezaei A, Nuyts J, Defrise M, Bal G, Michel C, Conti M, Watson C (2011) Simultaneous reconstruction of activity and attenuation in time-of-flight PET. Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Valencia, Spain, pp 2375–2382 Rezaei A, Nuyts J, Defrise M, Bal G, Michel C, Conti M, Watson C (2011) Simultaneous reconstruction of activity and attenuation in time-of-flight PET. Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Valencia, Spain, pp 2375–2382
28.
go back to reference Qian H, Shanbhag DD, Kaushik S, Thiruvenkadam S, Novak G, Lonn A, Wollenweber SD, Wiesinger F (2012) Whole-body PET/MR attenuation correction on a sequential, tri-modality PET/CT and MR imaging setup combing image segmentation, truncation completion and atlas-based skull segmentation. In: Proceedings new paradigms in molecular imaging conference, Elba, Italy, Tuesday 29th May Qian H, Shanbhag DD, Kaushik S, Thiruvenkadam S, Novak G, Lonn A, Wollenweber SD, Wiesinger F (2012) Whole-body PET/MR attenuation correction on a sequential, tri-modality PET/CT and MR imaging setup combing image segmentation, truncation completion and atlas-based skull segmentation. In: Proceedings new paradigms in molecular imaging conference, Elba, Italy, Tuesday 29th May
29.
go back to reference Shanbhag DD, Thiruvenkadam S, Kaushik S, Mullick R, Wollenweber SD, Wiesinger F (2012) Automated workflow for MR-PET attenuation correction in a tri-modality system using Dixon fat-water imaging based tissue classification. In: Proceedings of the international society of magnetic resonance in medicine, Melbourne, Australia, p 4371 Shanbhag DD, Thiruvenkadam S, Kaushik S, Mullick R, Wollenweber SD, Wiesinger F (2012) Automated workflow for MR-PET attenuation correction in a tri-modality system using Dixon fat-water imaging based tissue classification. In: Proceedings of the international society of magnetic resonance in medicine, Melbourne, Australia, p 4371
30.
go back to reference van Ufford HM, Kwee TC, Beek FJ, van Leeuwen MS, Takahara T, Fijnheer R, Nievelstein RA, de Klerk JM (2011) Newly diagnosed lymphoma: initial results with whole-body T1-weighted, STIR, and diffusion-weighted MRI compared with 18F-FDG PET/CT. AJR Am J Roentgenol 196(3):662–669PubMedCrossRef van Ufford HM, Kwee TC, Beek FJ, van Leeuwen MS, Takahara T, Fijnheer R, Nievelstein RA, de Klerk JM (2011) Newly diagnosed lymphoma: initial results with whole-body T1-weighted, STIR, and diffusion-weighted MRI compared with 18F-FDG PET/CT. AJR Am J Roentgenol 196(3):662–669PubMedCrossRef
31.
go back to reference Pauls S, Schmidt SA, Juchems MS, Klass O, Luster M, Reske SN, Brambs HJ, Feuerlein S (2012) Diffusion-weighted MR imaging in comparison to integrated [(1)(8)F]-FDG PET/CT for N-staging in patients with lung cancer. Eur J Radiol 81(1):178–182PubMedCrossRef Pauls S, Schmidt SA, Juchems MS, Klass O, Luster M, Reske SN, Brambs HJ, Feuerlein S (2012) Diffusion-weighted MR imaging in comparison to integrated [(1)(8)F]-FDG PET/CT for N-staging in patients with lung cancer. Eur J Radiol 81(1):178–182PubMedCrossRef
32.
go back to reference Chen W, Jian W, Li HT, Li C, Zhang YK, Xie B, Zhou DQ, Dai YM, Lin Y, Lu M, Huang XQ, Xu CX, Chen L (2010) Whole-body diffusion-weighted imaging vs. FDG-PET for the detection of non-small-cell lung cancer. How do they measure up? Magn Reson Imaging 28(5):613–620PubMedCrossRef Chen W, Jian W, Li HT, Li C, Zhang YK, Xie B, Zhou DQ, Dai YM, Lin Y, Lu M, Huang XQ, Xu CX, Chen L (2010) Whole-body diffusion-weighted imaging vs. FDG-PET for the detection of non-small-cell lung cancer. How do they measure up? Magn Reson Imaging 28(5):613–620PubMedCrossRef
33.
go back to reference Lin C, Luciani A, Itti E, Haioun C, Rahmouni A (2007) Whole body MRI and PET/CT in haematological malignancies. Cancer Imaging 7(Spec No A):S88–S93PubMedCrossRef Lin C, Luciani A, Itti E, Haioun C, Rahmouni A (2007) Whole body MRI and PET/CT in haematological malignancies. Cancer Imaging 7(Spec No A):S88–S93PubMedCrossRef
34.
go back to reference Lutje S, de Rooy JW, Croockewit S, Koedam E, Oyen WJ, Raymakers RA (2009) Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutical evaluation of patients with multiple myeloma. Ann Hematol 88(12):1161–1168PubMedCrossRef Lutje S, de Rooy JW, Croockewit S, Koedam E, Oyen WJ, Raymakers RA (2009) Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutical evaluation of patients with multiple myeloma. Ann Hematol 88(12):1161–1168PubMedCrossRef
35.
go back to reference Dellestable P, Granel-Brocard F, Rat AC, Olivier P, Regent D, Schmutz JL (2011) Impact of whole body magnetic resonance imaging (MRI) in the management of melanoma patients, in comparison with positron emission tomography/computed tomography (TEP/CT) and CT. Ann Dermatol Venereol 138(5):377–383PubMedCrossRef Dellestable P, Granel-Brocard F, Rat AC, Olivier P, Regent D, Schmutz JL (2011) Impact of whole body magnetic resonance imaging (MRI) in the management of melanoma patients, in comparison with positron emission tomography/computed tomography (TEP/CT) and CT. Ann Dermatol Venereol 138(5):377–383PubMedCrossRef
36.
go back to reference Aukema TS, Olmos RA, Korse CM, Kroon BB, Wouters MW, Vogel WV, Bonfrer JM, Nieweg OE (2010) Utility of FDG PET/CT and brain MRI in melanoma patients with increased serum S-100B level during follow-up. Ann Surg Oncol 17(6):1657–1661PubMedCrossRef Aukema TS, Olmos RA, Korse CM, Kroon BB, Wouters MW, Vogel WV, Bonfrer JM, Nieweg OE (2010) Utility of FDG PET/CT and brain MRI in melanoma patients with increased serum S-100B level during follow-up. Ann Surg Oncol 17(6):1657–1661PubMedCrossRef
37.
go back to reference Kuhn FP, Crook DW, Mader CE, Appenzeller P, von Schulthess GK, Schmid DT (2012) Discrimination and anatomical mapping of PET-positive lesions: comparison of CT attenuation-corrected PET images with coregistered MR and CT images in the abdomen. Eur J Nucl Med Mol Imaging [Epub ahead of print] Kuhn FP, Crook DW, Mader CE, Appenzeller P, von Schulthess GK, Schmid DT (2012) Discrimination and anatomical mapping of PET-positive lesions: comparison of CT attenuation-corrected PET images with coregistered MR and CT images in the abdomen. Eur J Nucl Med Mol Imaging [Epub ahead of print]
38.
go back to reference Niekel MC, Bipat S, Stoker J (2010) Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT: a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology 257(3):674–684PubMedCrossRef Niekel MC, Bipat S, Stoker J (2010) Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT: a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology 257(3):674–684PubMedCrossRef
39.
go back to reference Strobel K, Bode B, Dummer R, Veit-Haibach P, Fischer DR, Imhof L, Goldinger S, Steinert HC, von Schulthess GK (2009) Limited value of 18F-FDG PET/CT and S-100B tumour marker in the detection of liver metastases from uveal melanoma compared to liver metastases from cutaneous melanoma. Eur J Nucl Med Mol Imaging 36(11):1774–1782PubMedCrossRef Strobel K, Bode B, Dummer R, Veit-Haibach P, Fischer DR, Imhof L, Goldinger S, Steinert HC, von Schulthess GK (2009) Limited value of 18F-FDG PET/CT and S-100B tumour marker in the detection of liver metastases from uveal melanoma compared to liver metastases from cutaneous melanoma. Eur J Nucl Med Mol Imaging 36(11):1774–1782PubMedCrossRef
40.
go back to reference Veit-Haibach P, Schiesser M, Soyka J, Strobel K, Schaefer NG, Hesselmann R, Clavien PA, Hany TF (2011) Clinical value of a combined multi-phase contrast enhanced DOPA-PET/CT in neuroendocrine tumours with emphasis on the diagnostic CT component. Eur Radiol 21(2):256–264PubMedCrossRef Veit-Haibach P, Schiesser M, Soyka J, Strobel K, Schaefer NG, Hesselmann R, Clavien PA, Hany TF (2011) Clinical value of a combined multi-phase contrast enhanced DOPA-PET/CT in neuroendocrine tumours with emphasis on the diagnostic CT component. Eur Radiol 21(2):256–264PubMedCrossRef
41.
go back to reference Schiesser M, Veit-Haibach P, Muller MK, Weber M, Bauerfeind P, Hany T, Clavien PA (2010) Value of combined 6-[18F]fluorodihydroxyphenylalanine PET/CT for imaging of neuroendocrine tumours. Br J Surg 97(5):691–697PubMedCrossRef Schiesser M, Veit-Haibach P, Muller MK, Weber M, Bauerfeind P, Hany T, Clavien PA (2010) Value of combined 6-[18F]fluorodihydroxyphenylalanine PET/CT for imaging of neuroendocrine tumours. Br J Surg 97(5):691–697PubMedCrossRef
42.
go back to reference Ambrosini V, Tomassetti P, Franchi R, Fanti S (2010) Imaging of NETs with PET radiopharmaceuticals. Q J Nucl Med Mol Imaging 54(1):16–23PubMed Ambrosini V, Tomassetti P, Franchi R, Fanti S (2010) Imaging of NETs with PET radiopharmaceuticals. Q J Nucl Med Mol Imaging 54(1):16–23PubMed
43.
go back to reference Narin B, Ajaj W, Gohde S, Langhorst J, Akgoz H, Gerken G, Ruhm SG, Lauenstein TC (2004) Combined small and large bowel MR imaging in patients with Crohn’s disease: a feasibility study. Eur Radiol 14(9):1535–1542PubMedCrossRef Narin B, Ajaj W, Gohde S, Langhorst J, Akgoz H, Gerken G, Ruhm SG, Lauenstein TC (2004) Combined small and large bowel MR imaging in patients with Crohn’s disease: a feasibility study. Eur Radiol 14(9):1535–1542PubMedCrossRef
44.
go back to reference Ajaj WM, Lauenstein TC, Pelster G, Gerken G, Ruehm SG, Debatin JF, Goehde SC (2005) Magnetic resonance colonography for the detection of inflammatory diseases of the large bowel: quantifying the inflammatory activity. Gut 54(2):257–263PubMedCrossRef Ajaj WM, Lauenstein TC, Pelster G, Gerken G, Ruehm SG, Debatin JF, Goehde SC (2005) Magnetic resonance colonography for the detection of inflammatory diseases of the large bowel: quantifying the inflammatory activity. Gut 54(2):257–263PubMedCrossRef
45.
go back to reference Love C, Tomas MB, Tronco GG, Palestro CJ (2005) FDG PET of infection and inflammation. Radiographics 25(5):1357–1368PubMedCrossRef Love C, Tomas MB, Tronco GG, Palestro CJ (2005) FDG PET of infection and inflammation. Radiographics 25(5):1357–1368PubMedCrossRef
46.
go back to reference Stumpe KD, Strobel K (2006) 18F FDG-PET imaging in musculoskeletal infection. Q J Nucl Med Mol Imaging 50(2):131–142PubMed Stumpe KD, Strobel K (2006) 18F FDG-PET imaging in musculoskeletal infection. Q J Nucl Med Mol Imaging 50(2):131–142PubMed
47.
go back to reference Strobel K, Stumpe KD (2007) PET/CT in musculoskeletal infection. Semin Musculoskelet Radiol 11(4):353–364PubMedCrossRef Strobel K, Stumpe KD (2007) PET/CT in musculoskeletal infection. Semin Musculoskelet Radiol 11(4):353–364PubMedCrossRef
48.
go back to reference Castellucci P, Fuccio C, Rubello D, Schiavina R, Santi I, Nanni C, Allegri V, Montini GC, Ambrosini V, Boschi S, Martorana G, Marzola MC, Fanti S (2011) Is there a role for (1)(1)C-choline PET/CT in the early detection of metastatic disease in surgically treated prostate cancer patients with a mild PSA increase <1.5 ng/ml? Eur J Nucl Med Mol Imaging 38(1):55–63PubMedCrossRef Castellucci P, Fuccio C, Rubello D, Schiavina R, Santi I, Nanni C, Allegri V, Montini GC, Ambrosini V, Boschi S, Martorana G, Marzola MC, Fanti S (2011) Is there a role for (1)(1)C-choline PET/CT in the early detection of metastatic disease in surgically treated prostate cancer patients with a mild PSA increase <1.5 ng/ml? Eur J Nucl Med Mol Imaging 38(1):55–63PubMedCrossRef
49.
go back to reference Castellucci P, Fuccio C, Nanni C, Santi I, Rizzello A, Lodi F, Franceschelli A, Martorana G, Manferrari F, Fanti S (2009) Influence of trigger PSA and PSA kinetics on 11C-Choline PET/CT detection rate in patients with biochemical relapse after radical prostatectomy. J Nucl Med 50(9):1394–1400PubMedCrossRef Castellucci P, Fuccio C, Nanni C, Santi I, Rizzello A, Lodi F, Franceschelli A, Martorana G, Manferrari F, Fanti S (2009) Influence of trigger PSA and PSA kinetics on 11C-Choline PET/CT detection rate in patients with biochemical relapse after radical prostatectomy. J Nucl Med 50(9):1394–1400PubMedCrossRef
50.
go back to reference Veit-Haibach P, Luczak C, Wanke I, Fischer M, Egelhof T, Beyer T, Dahmen G, Bockisch A, Rosenbaum S, Antoch G (2007) TNM staging with FDG-PET/CT in patients with primary head and neck cancer. Eur J Nucl Med Mol Imaging 34(12):1953–1962PubMedCrossRef Veit-Haibach P, Luczak C, Wanke I, Fischer M, Egelhof T, Beyer T, Dahmen G, Bockisch A, Rosenbaum S, Antoch G (2007) TNM staging with FDG-PET/CT in patients with primary head and neck cancer. Eur J Nucl Med Mol Imaging 34(12):1953–1962PubMedCrossRef
51.
go back to reference Gore JC, Manning HC, Quarles CC, Waddell KW, Yankeelov TE (2011) Magnetic resonance in the era of molecular imaging of cancer. Magn Reson Imaging 29(5):587–600PubMedCrossRef Gore JC, Manning HC, Quarles CC, Waddell KW, Yankeelov TE (2011) Magnetic resonance in the era of molecular imaging of cancer. Magn Reson Imaging 29(5):587–600PubMedCrossRef
52.
go back to reference Dhermain FG, Hau P, Lanfermann H, Jacobs AH, van den Bent MJ (2010) Advanced MRI and PET imaging for assessment of treatment response in patients with gliomas. Lancet Neurol 9(9):906–920PubMedCrossRef Dhermain FG, Hau P, Lanfermann H, Jacobs AH, van den Bent MJ (2010) Advanced MRI and PET imaging for assessment of treatment response in patients with gliomas. Lancet Neurol 9(9):906–920PubMedCrossRef
53.
go back to reference de Bondt RB, Hoeberigs MC, Nelemans PJ, Deserno WM, Peutz-Kootstra C, Kremer B, Beets-Tan RG (2009) Diagnostic accuracy and additional value of diffusion-weighted imaging for discrimination of malignant cervical lymph nodes in head and neck squamous cell carcinoma. Neuroradiology 51(3):183–192PubMedCrossRef de Bondt RB, Hoeberigs MC, Nelemans PJ, Deserno WM, Peutz-Kootstra C, Kremer B, Beets-Tan RG (2009) Diagnostic accuracy and additional value of diffusion-weighted imaging for discrimination of malignant cervical lymph nodes in head and neck squamous cell carcinoma. Neuroradiology 51(3):183–192PubMedCrossRef
54.
go back to reference Detre JA, Rao H, Wang DJ, Chen YF, Wang Z (2012) Applications of arterial spin labeled MRI in the brain. J Magn Reson Imaging 35(5):1026–1037PubMedCrossRef Detre JA, Rao H, Wang DJ, Chen YF, Wang Z (2012) Applications of arterial spin labeled MRI in the brain. J Magn Reson Imaging 35(5):1026–1037PubMedCrossRef
55.
go back to reference Yankeelov TE, Gore JC (2009) Dynamic contrast enhanced magnetic resonance imaging in oncology: theory, data acquisition, analysis, and examples. Curr Med Imaging Rev 3(2):91–107PubMedCrossRef Yankeelov TE, Gore JC (2009) Dynamic contrast enhanced magnetic resonance imaging in oncology: theory, data acquisition, analysis, and examples. Curr Med Imaging Rev 3(2):91–107PubMedCrossRef
56.
go back to reference Bisdas S, Spicer K, Rumboldt Z (2008) Whole-tumor perfusion CT parameters and glucose metabolism measurements in head and neck squamous cell carcinomas: a pilot study using combined positron-emission tomography/CT imaging. AJNR Am J Neuroradiol 29(7):1376–1381PubMedCrossRef Bisdas S, Spicer K, Rumboldt Z (2008) Whole-tumor perfusion CT parameters and glucose metabolism measurements in head and neck squamous cell carcinomas: a pilot study using combined positron-emission tomography/CT imaging. AJNR Am J Neuroradiol 29(7):1376–1381PubMedCrossRef
57.
go back to reference Veit-Haibach P, Treyer V, Strobel K, Soyka JD, Husmann L, Schaefer NG, Tschopp A, Hany TF (2010) Feasibility of integrated CT-liver perfusion in routine FDG-PET/CT. Abdom Imaging 35(5):528–536PubMedCrossRef Veit-Haibach P, Treyer V, Strobel K, Soyka JD, Husmann L, Schaefer NG, Tschopp A, Hany TF (2010) Feasibility of integrated CT-liver perfusion in routine FDG-PET/CT. Abdom Imaging 35(5):528–536PubMedCrossRef
58.
go back to reference Bokkers RP, Hernandez DA, Merino JG, Mirasol RV, van Osch MJ, Hendrikse J, Warach S, Latour LL (2012) Whole-brain arterial spin labeling perfusion MRI in patients with acute stroke. Stroke. doi:10.1161/STROKEAHA.110.589234 Bokkers RP, Hernandez DA, Merino JG, Mirasol RV, van Osch MJ, Hendrikse J, Warach S, Latour LL (2012) Whole-brain arterial spin labeling perfusion MRI in patients with acute stroke. Stroke. doi:10.​1161/​STROKEAHA.​110.​589234
59.
go back to reference Pedrosa I, Rafatzand K, Robson P, Wagner AA, Atkins MB, Rofsky NM, Alsop DC (2012) Arterial spin labeling MR imaging for characterisation of renal masses in patients with impaired renal function: initial experience. Eur Radiol 22(2):484–492PubMedCrossRef Pedrosa I, Rafatzand K, Robson P, Wagner AA, Atkins MB, Rofsky NM, Alsop DC (2012) Arterial spin labeling MR imaging for characterisation of renal masses in patients with impaired renal function: initial experience. Eur Radiol 22(2):484–492PubMedCrossRef
Metadata
Title
PET–MR imaging using a tri-modality PET/CT–MR system with a dedicated shuttle in clinical routine
Authors
Patrick Veit-Haibach
Felix Pierre Kuhn
Florian Wiesinger
Gaspar Delso
Gustav von Schulthess
Publication date
01-02-2013
Publisher
Springer-Verlag
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2013
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-012-0344-5

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