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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 10/2019

Open Access 01-09-2019 | Computed Tomography | Review Article

Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence

Authors: Ora Israel, O. Pellet, L. Biassoni, D. De Palma, E. Estrada-Lobato, G. Gnanasegaran, T. Kuwert, C. la Fougère, G. Mariani, S. Massalha, D. Paez, F. Giammarile

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2019

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Abstract

Purpose

Single-photon emission computed tomography (SPECT) combined with computed tomography (CT) was introduced as a hybrid SPECT/CT imaging modality two decades ago. The main advantage of SPECT/CT is the increased specificity achieved through a more precise localization and characterization of functional findings. The improved diagnostic accuracy is also associated with greater diagnostic confidence and better inter-specialty communication.

Methods

This review presents a critical assessment of the relevant literature published so far on the role of SPECT/CT in a variety of clinical conditions. It also includes an update on the established evidence demonstrating both the advantages and limitations of this modality.

Conclusions

For the majority of applications, SPECT/CT should be a routine imaging technique, fully integrated into the clinical decision-making process, including oncology, endocrinology, orthopaedics, paediatrics, and cardiology. Large-scale prospective studies are lacking, however, on the use of SPECT/CT in certain clinical domains such as neurology and lung disorders. The review also presents data on the complementary role of SPECT/CT with other imaging modalities and a comparative analysis, where available.
Appendix
Available only for authorised users
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Metadata
Title
Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence
Authors
Ora Israel
O. Pellet
L. Biassoni
D. De Palma
E. Estrada-Lobato
G. Gnanasegaran
T. Kuwert
C. la Fougère
G. Mariani
S. Massalha
D. Paez
F. Giammarile
Publication date
01-09-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2019
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-019-04404-6

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