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Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Linear IgA Disease | Case report

An unusual case of linear IgA disease affecting only the oral gingiva: a case report

Authors: Jianing He, Jun Shen, Wei Guo

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Background

We present a case report on desquamative gingivitis diagnosed as linear IgA disease (LAD), which is a rare autoimmune bullous disease exclusively affecting the oral gingiva. The oral mucosa can be impacted by various autoimmune bullous diseases, and our report focuses on this particular manifestation of LAD.

Case presentation

This patient presented with atypical symptoms, as frequent blister formation on the gingiva was the primary clinical manifestation. A combination of systemic and local treatment was administered to the patient. Following the treatment, there was a significant improvement observed in both the erythema and the bullous lesions on the gingiva.

Conclusions

A more suitable local treatment strategy should be formulated for patients presenting with oral topical lesions, which clinicians can employ effectively.
Literature
1.
go back to reference Robinson NA, Wray D. Desquamative gingivitis: a sign of mucocutaneous disorders–a review. Aust Dent J. 2003;48(4):206–11.CrossRefPubMed Robinson NA, Wray D. Desquamative gingivitis: a sign of mucocutaneous disorders–a review. Aust Dent J. 2003;48(4):206–11.CrossRefPubMed
2.
go back to reference Gagari E, Damoulis PD. Desquamative gingivitis as a manifestation of chronic mucocutaneous disease. J Dtsch Dermatol Ges. 2011;9(3):184–8.PubMed Gagari E, Damoulis PD. Desquamative gingivitis as a manifestation of chronic mucocutaneous disease. J Dtsch Dermatol Ges. 2011;9(3):184–8.PubMed
3.
go back to reference Maderal AD, Lee SPR, Jorizzo JL. Desquamative gingivitis: diagnosis and treatment. J Am Acad Dermatol. 2018;78(5):851–61.CrossRefPubMed Maderal AD, Lee SPR, Jorizzo JL. Desquamative gingivitis: diagnosis and treatment. J Am Acad Dermatol. 2018;78(5):851–61.CrossRefPubMed
4.
go back to reference Hasan S. Desquamative gingivitis - a clinical sign in mucous membrane pemphigoid: report of a case and review of literature. J Pharm Bioallied Sci. 2014;6(2):122–6.CrossRefPubMedPubMedCentral Hasan S. Desquamative gingivitis - a clinical sign in mucous membrane pemphigoid: report of a case and review of literature. J Pharm Bioallied Sci. 2014;6(2):122–6.CrossRefPubMedPubMedCentral
5.
go back to reference Hashimoto T, Yamagami J, Zone JJ. History, diagnosis, pathogenesis, and nomenclature in sublamina densa-type linear IgA disease. JAMA Dermatol. 2021;157(8):907–9.CrossRefPubMed Hashimoto T, Yamagami J, Zone JJ. History, diagnosis, pathogenesis, and nomenclature in sublamina densa-type linear IgA disease. JAMA Dermatol. 2021;157(8):907–9.CrossRefPubMed
6.
go back to reference Angiero F, Benedicenti S, Crippa R, et al. A rare case of desquamative gingivitis due to linear IgA disease: morphological and immunofluorescence features. In Vivo. 2007;21(6):1093–8.PubMed Angiero F, Benedicenti S, Crippa R, et al. A rare case of desquamative gingivitis due to linear IgA disease: morphological and immunofluorescence features. In Vivo. 2007;21(6):1093–8.PubMed
7.
go back to reference Vale E, Dimatos OC, Porro AM, et al. Consensus on the treatment of autoimmune bullous dermatoses: dermatitis herpetiformis and linear IgA bullous dermatosis - Brazilian Society of Dermatology. An Bras Dermatol. 2019;94(2 Suppl 1):48–55.CrossRefPubMedPubMedCentral Vale E, Dimatos OC, Porro AM, et al. Consensus on the treatment of autoimmune bullous dermatoses: dermatitis herpetiformis and linear IgA bullous dermatosis - Brazilian Society of Dermatology. An Bras Dermatol. 2019;94(2 Suppl 1):48–55.CrossRefPubMedPubMedCentral
8.
go back to reference Challacombe SJ, Setterfield J, Shirlaw P, et al. Immunodiagnosis of pemphigus and mucous membrane pemphigoid. Acta Odontol Scand. 2001;59(4):226–34.CrossRefPubMed Challacombe SJ, Setterfield J, Shirlaw P, et al. Immunodiagnosis of pemphigus and mucous membrane pemphigoid. Acta Odontol Scand. 2001;59(4):226–34.CrossRefPubMed
9.
go back to reference Matsumoto T, Nakamura S, Ishii N, et al. Erythrodermic linear IgA/IgG bullous dermatosis. Eur J Dermatol. 2019;29(2):220–1.CrossRefPubMed Matsumoto T, Nakamura S, Ishii N, et al. Erythrodermic linear IgA/IgG bullous dermatosis. Eur J Dermatol. 2019;29(2):220–1.CrossRefPubMed
10.
go back to reference Lally A, Chamberlain A, Allen J, et al. Dermal-binding linear IgA disease: an uncommon subset of a rare immunobullous disease. Clin Exp Dermatol. 2007;32(5):493–8.CrossRefPubMed Lally A, Chamberlain A, Allen J, et al. Dermal-binding linear IgA disease: an uncommon subset of a rare immunobullous disease. Clin Exp Dermatol. 2007;32(5):493–8.CrossRefPubMed
11.
go back to reference Shin L, Gardner JN, Dao HJ. Updates in the diagnosis and management of linear IgA disease: a systematic review. Medicina (Kaunas). 2021;57(8):818.CrossRefPubMed Shin L, Gardner JN, Dao HJ. Updates in the diagnosis and management of linear IgA disease: a systematic review. Medicina (Kaunas). 2021;57(8):818.CrossRefPubMed
12.
go back to reference Garcia-Pola MJ, Rodriguez-Lopez S, Fernanz-Vigil A, et al. Oral hygiene instructions and professional control as part of the treatment of desquamative gingivitis. Systematic review. Med Oral Patol Oral Cir Bucal. 2019;24(2):e136-44.PubMedPubMedCentral Garcia-Pola MJ, Rodriguez-Lopez S, Fernanz-Vigil A, et al. Oral hygiene instructions and professional control as part of the treatment of desquamative gingivitis. Systematic review. Med Oral Patol Oral Cir Bucal. 2019;24(2):e136-44.PubMedPubMedCentral
Metadata
Title
An unusual case of linear IgA disease affecting only the oral gingiva: a case report
Authors
Jianing He
Jun Shen
Wei Guo
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-03250-1

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